猪免疫口蹄疫灭活疫苗后外周血细胞亚群变化的研究

doi:10.16431/j.cnki.1671-7236.2016.04.024

Abstract

Abstract: In order to investigate the change of lymphocyte subpopulations in the peripheral blood after injection of foot-and-mouth disease inactivated vaccine, blood samples were collected after vaccination and assayed with flow cytometry.The results showed that the proportion of dendritic cells (DCs) increased significantly in a short time after vaccination, after which the number of B cells, helper T (Th) cells and cytotoxic lymphocytes (CTLs) also raised with significance.The changing trend of B cells proportion was highly relevant with Th cells and a same correlation also appeared in the antibody titers.This indicated that the innate immune system could be activated rapidly after vaccination with the inactivated vaccine, and the adaptive immune response including cellular immune response and humoral immune response could be invoked subsequently.The high level of neutralizing antibodies was of great importance in evading FMDV and the cellular immune response also exerted a crucial role.

Key words: foot-and-mouth disease virus; Th cell; CTLs; B cell; DCs

CLC Number:

S852.65⁺9.6

ZHANG Liu, FENG Xia, JIN Ye, QI Shu-yun, ZHANG Xiao-xia, MA Jun-wu. Study on Change of Lymphocyte Subpopulations in Swine after Immunization with Inactivated Vaccine[J]. , 2016, 43(4): 1012-1016.

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Study on Change of Lymphocyte Subpopulations in Swine after Immunization with Inactivated Vaccine

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