Abstract: The penicillic acid mainly is the metabolite which produces by the Penicillium cyclopium，may achieve 2% in the feed highest content. The penicillic acid harms one of fish breeding and poultry raising common mold toxin,feeds for a long time including the penicillic acid feed,can cause the animal liver to be tumescent, the liver cell denaturation and can suppress the zooblast DNA synthesis,Serious may cause the zooblast DNA break. The penicillic acid can have the union toxicity with other mold toxin, if affects together with other mold toxin can have a bigger toxicity. This article to aspect and so on penicillic acid structure, nature, harm, toxic, examination method and detoxication mechanism research has carried on the summary.

Key words: penicillic acid; toxicity; detoxification