Abstract: Bacteria culture isolation and antibiotic sensitivity tests from 516 animals in Zhejiang province had been performed from 2002 to 2005. The main pathogens isolated were staphylococci, streptococci and E.coli, being 18.92% of total isolated bacteria in 2002~2003, 24% in 2003~2004 and 16.21% in 2004~2005. Among grampositive coccobacteria, staphylococci occupied 6.90% in 2002 and increased to 23.25% in 2005. Drugresistance of these three main pathogens to sulfamethoxazole ,tetracycline, kanamycin, streptomycin were 88.78%, 100%, 83.33% and 82.22%. Drug-resistance of staphylococci and E.coli to enoxacin was 11.31% and 22.62%, respectively, suggesting enoxacin had efficiently Bactericidal effect on staphylococci and E.coli. Similarly, ampicillin showed bactericidal effect on streptococci and only 34.32% of streptococci isolated in 2002~2005 showed ampicillinresistance. These results suggest that drugresistance of pathogens isolated from animals increase gradually.

Key words: pathogens isolation; antibiotic sensitivity tests; trends of drug-resistance 