Abstract: In the research ,direct microscopic exam, hematology inspection, idodine brake test, vigor experiment were used to diagnose 20 dogs admitted by animal hospital. As a result, 18 of them were determined dominant or latent H.Canis . Refering to the above diagnosis experiment, 10 dogs were sampled out at random among the 18 infectious dogs and were divided into 5 groups to carry on in vivo pharmacokenetics experiment. The dogs were injected Berenil+Imidocarb , Berenil, Imidocarb and Special effect Mi Xian respectively in different groups; the last group is a control group, The results indicated that Berenil combining with Imidocarb shows the best effects; Berenil and Imidocarb used separately were secondly effective; Special effect Mi Xian respectively hardly showed any effects. 

Key words: canine; H.canis; diagnosis; treatment