犬肿瘤免疫治疗性抗体研究进展及方向

doi:10.16431/j.cnki.1671-7236.2025.05.045

Abstract

Abstract: Cancer has become a big threat to the health of canines,especially for those over the age of 10.Given the same living environment shared between dogs and humans,and high degree of genetic homology,research on the mechanisms of canine tumor occurrence,progression,and effective treatments is not only crucial for pet dogs,but also provides valuable models and insights for human cancer research.In veterinary clinic,the conventional treatment for canine tumors includes surgical resection,chemotherapy and radiotherapy.Although they have certain curative effects,some side effects and limitations accompanied cannot be ignored.While immunotherapy has brought new hope and perspectives to the treatment of cancer due to its high safety and efficacy.With its rapid development,antibody therapy is making new breakthroughs.And therapeutic antibodies are used to treat various human tumors for their high affinity and selectivity.However,compared to the field of human medicine,the application of antibody therapy in veterinary oncology clinical practice is relatively limited.Here after combined the application of antibody therapy in human tumor treatment,the latest progress and potential research directions of therapeutic antibodies in canine tumor research were reviewed,aiming to provide new ideas for research and clinical trials in canine tumor treatment.

Key words: canine tumor; immunotherapy; antibody

CLC Number:

S858.292

QIN Mengke, LI Huixin, HAN Hui, MENG Qingda, XIE Shanshan. Research Progress and Direction of Immunotherapeutic Antibodies for Canine Tumor[J]. China Animal Husbandry and Veterinary Medicine, 2025, 52(5): 2432-2441.

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Research Progress and Direction of Immunotherapeutic Antibodies for Canine Tumor

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