Abstract: With the rapid development of the breeding industry,the application of veterinary antibacterial drugs is more and more extensive.However,due to the unreasonable selection and abuse of antimicrobial drugs,the resistance rate of bacteria to antimicrobial drugs is gradually increasing,and almost all bacteria have acquired resistance genes.At present,bacterial resistance has become a global problem,and clinically,the cause of the disease is complex,often manifested as a variety of pathogens secondary infection and mixed infection,single drug is often difficult to effectively control the disease,seriously endangering the development of aquaculture.The combination of antibiotics can improve the therapeutic effect of drugs,alleviate or reduce adverse reactions,reduce the incidence of bacterial resistance.For cases of mixed infection or unable to carry out bacteriological diagnosis,the combination of antibiotics can also expand the scope of antibacterial.The combination model of PK and PD can effectively integrate the relationship among drugs,organism and pathogenic bacteria,and provide a reasonable medication plan for clinical use.Therefore,by introducing the advantages and problems of the combination of drugs,the classification of PK/PD and the optimization and guidance of PK/PD on the combination of drugs,this paper summarizes the research progress of PK-PD on the combination of veterinary drugs and antibacterial drugs at present,in order to promote the rational use of veterinary clinical antibacterial drugs.

Key words: antibacterial drugs; combination drug; PK/PD