鸡新城疫－传染性支气管炎－传染性法氏囊病三联灭活疫苗对不同日龄雏鸡的免疫效力研究

doi:10.16431/j.cnki.1671-7236.2019.03.031

Abstract

Abstract:

To evaluate immune efficacy and immune duration of a trivalent inactivated vaccine against Newcastle disease (ND),infectious bronchitis (IB) and infectious bursal disease (IBD),the vaccine was administered to SPF and common healthy chicks with maternal antibodies at age of 7,14 and 21 days old.The blood samples of the chicks were collected at 21 d after vaccination,then ND haemagglutination inhibition antibody (HI Ab),IB HI Ab and IBD neutralizing antibody (NA) of the blood samples were examined,and virulent IBDV challenge were carried out.The results showed that the ND HI Ab,IB HI Ab and IBD NA titers of SPF chicks at 7 days old were 7.9log2,6.9log2 and 14.1log2,respectively,and the older the SPF chicks,the higher the antibody level.Three months after immunization,the ND HI Ab,IB HI Ab and IBD NA titers of chicks immused with 3 mL vaccine reached 6.5log2,6.1log2 and 13.6log2 respectively,and the protection rate against IBDV challenge was 100% (10/10).The immune effect of common chicks was almost similar with SPF chicks,the antibody levels increased with the age of the chicks,and the protection rate against IBDV was 100% (10/10).The results confirmed that the different days old chicks inoculated with the trivalent inactivated vaccine could produce good immunity to against virulent IBDV challenge,the immunity duration of the triple inactivated vaccine was 3 months at least.

Key words: Newcastle disease (ND); infectious bronchitis (IB); infectious bursal disease (IBD); trivalent inactivated vaccine; immune efficacy; immune duration

CLC Number:

S858.31

SHEN Jia, SHI Aihua, ZHANG Zhenhua, LI Lin, JING Xiaodong, ZHANG Jianwei, ZHENG Xiaolan, JIANG Beiyu. Study on the Immune Efficacy of A Trivalent Inactivated Vaccine Against Newcastle Disease, Infectious Bronchitis and Infectious Bursal Disease in Different Days Old Chicks[J]. , 2019, 46(3): 898-904.

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Study on the Immune Efficacy of A Trivalent Inactivated Vaccine Against Newcastle Disease, Infectious Bronchitis and Infectious Bursal Disease in Different Days Old Chicks

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