SMAD3基因在畜牧生产中的应用研究进展

doi:10.16431/j.cnki.1671-7236.2019.01.021

Abstract

Abstract:

SMAD3 gene is one of the members of the SMADs gene family,and the SMAD3 protein which encoded by SMAD3 gene,is the special intracellular signal transduction molecule of TGF-β super gene family.Not only SMAD3 gene participates in regulating many aspects of important physiological processes via the superfamily of TGF-β,such as disease,immune regulation,growth and development,wound healing,development and maintenance of cartilages and bones,but also involves in regulating physiological activities in animal,for example,the proliferation,differentiation,maturation,adhesion,atresia,apoptosis of germ cells,and secretion of steroid hormone.Therefore,it's of great significance to understand the structure and function of SMAD3 gene for the researches relating to animal growth,development and reproduction.This review sketched the structure,function,mechanism of SMAD3 gene,and analysized its research progress of the application in livestock production.It showed that a large number of researches about the application of SMAD3 gene in animal production was mainly focus on aspects of growth regulation,development,cell immunity and apoptosis,hormone secretion and reproductive performance of vertebrate (pigs,cattle,sheep,chickens,etc).Regulations of SMAD3 gene in disease,growth and development,fat deposition and reproductive performance were still hot in domestic and abroad.However,the precise molecular regulation mechanism of this gene on disease occurrence,growth and reproductive performance remains to be further researched.

Key words: SMAD3 gene; transforming growth factor-β (TGF-β); mechanism; animal production

CLC Number:

S852.23

TAN Bin, YANG Shenglin, YANG Rucai, WANG Xuping, ZHOU Meidi, ZHOU Xuan, YANG Shihao. Application Research Progress of SMAD3 Gene in Livestock Production[J]. , 2019, 46(1): 185-193.

References

[1] PANGAS S A.Bone morphogenetic protein signaling transcription factor (SMAD) function in granulosa cells[J].Molecular & Cellular Endocrinology,2012,356(1-2):40-47.
[2] SHELLING A N.Mutations in inhibin and active ingenes associated with human disease[J].Molecular & Cellular Endocrinology,2012,359(1-2):113-120.
[3] WAN M,LI C,ZHEN G,et al.Injury-activated transforming growth factor β controls mobilization of mesenchymal stem cells for tissue remodeling[J].Stem Cells,2012,30(11):2498.
[4] DETOURNAY O,SCHNITZLER C E,POOLE A,et al.Regulation of cnidarian-dinoflagellate mutualisms:Evidence that activation of a host TGF-β innateimmune pathway promotes tolerance of the symbiont[J].Developmental & Comparative Immunology,2012,38(4):525-537.
[5] SEKELSKY J J,NEWFELD S J,RAFTERY L A,et al.Genetic characterization and cloning of mothers against dpp,a gene required for decapentaplegic function in Drosophila melanogaster[J].Genetics,1995,139(3):1347-1358.
[6] ITOH S,ITOH F,GOUMANS M J,et al.Signaling of transforming growth factor-β family members through Smad proteins[J].European Journal of Biochemistry,2000,267(24):6954-6967.
[7] LO R S,CHEN Y,SHI Y,et al.The L3 loop:A structural motif determining specific interactions between SMAD proteins and TGF-β receptors[J].The EMBO Journal,1998,17(4):996-1005.
[8] CHACKO B M,QIN B,CORREIA J J,et al.The L3 loop and C-terminal phosphorylation jointly define SMAD protein trimerization[J].Nature Structural Biology,2001,8(3):248-253.
[9] TSURUTANI Y,FUJIMOTO M,TAKEMOTO M,et al.The roles of transforming growth factor-β and Smad3 signaling in adipocyte differentiation and obesity[J].Biochemical and Biophysical Research Communications,2011,407(1):68-73.
[10] KIM W K,CHOI H R,PARK S G,et al.Myostatin inhibits brown adipocyte differentiation via regulation of Smad3-mediated β-catenin stabilization[J].International Journal of Biochemistry & Cell Biology,2012,44(2):327-334.
[11] YANG X,LETTERIO J J,LECHLEIDER R J,et al.Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta[J]. The EMBO Journal,1999,18(5):1280-1291.
[12] LIU Z,KUANDU-ROY T,MATSUURA I,et al.Carcinogen7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild typemice[J].Oncotarget,2016,7(40):64878-64885.
[13] HUANG J J,BLOBE G C.Dichotomous roles of TGF-β in human cancer[J].Biochemical Society Transactions,2016,44(5):1441-1454.
[14] 廖茂帆.SMAD3基因多态性与颅内散发动脉瘤的相关性研究[D].重庆:第三军医大学,2017. LIAO M F.Association between polymorphism of SMAD3 gene and risk of sporadic intracranial arterial aneurysms[D].Chongqing:Third Military Medical University,2017.(in Chinese)
[15] 刘敏,熊成名,王子豫,等.丹参酮ⅡA对肝癌细胞MHCC97-H Smad3/Smad7蛋白及上皮间质转化的影响[J].中医药导报,2017,10:30-34. LIU M,XIONG C M,WANG Z Y,et al.Effect of tanshinone ⅡA on phosphorylation of Smad3/Smad7 protein and epithelial mesenchymal transition of hepatocellular carcinoma cell line MHCC97-H[J].Guiding Journal of Traditional Chinese Medicine and Pharmacy,2017,10:30-34.(in Chinese)
[16] 王哲,张敬,陈怀安,等.TRAP1通过TGF/Smad3通路对膀胱癌的迁移和侵袭能力的影响[J].中国免疫学杂志,2017,33(9):1306-1309. WANG Z,ZHANG J,CHEN H A,et al.Effect of TRAP1 on invasion and migration of human bladdercancer through TGF/Smad3 signal pathway[J].Chinese Journal of Immunology,2017,33(9):1306-1309.(in Chinese)
[17] 陈婷婷,郑丰平,谭嗣伟,等.Smad3磷酸化促进溃疡性结肠炎的黏膜修复[J].新医学,2014,45(2):88-94. CHEN T T,ZHENG F P,TAN S T,et al.Smad3 phosphorylation contributes to the recovery of ulcerative colitis[J].Journal of New Medicine,2014,45(2):88-94.(in Chinese)
[18] BRADY K,DICKINSON S C,GUILLOT P V,et al.Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis[J].Stem Cells & Development,2014,23(5):541-554.
[19] 张娟.Smad2、Smad3及Smad7蛋白在绝经过渡期大鼠卵巢中的表达及意义[D].张家口:河北北方学院,2017. ZHANG J.The expression and significance of Smad protein in the ovary of the rat during menopausal transition[D].Zhangjiakou:Hebei North University,2017.(in Chinese)
[20] DEANS R,ABBOTT J.Review of intrauterine adhesions[J].Journal of Minimally Invasive Gynecology,2010,17(5):555-569.
[21] AZIZI R,AGHEBATIMALEKI L,NOURI M,et al.Stem cell therapy in asherman syndrome and thin endometrium:Stem cell-based therapy[J].Biomedicine & Pharmacotherapy,2018,102:333-343.
[22] 路静,王玉平,张霆,等.β-catenin、Smad3及TGF-β1在宫腔黏连患者子宫内膜组织中的表达及意义[J].中国妇幼健康研究,2017,28(7):793-796. LU J,WANG Y Y,ZHANG T,et al.Expressions and significance of β-catenin,Smad3 and TGF-β1 in endometrium of patients with intrauterine adhesion[J].Chinese Journal of Woman and Child Health Research,2017,28(7):793-796.(in Chinese)
[23] 周曼萍,何援利,刘芳.miR-29a、TGF-β1、Smad2及Smad3在宫腔粘连中的表达及意义[J].实用医学杂志,2014,30(8):1231-1234. ZHOU M P,HE Y L,LIU F.Expression and significance of miR-29a,TGF-β1,Smad2 and Smad3 in endometrium of patient with intrauterine adhesions[J].The Journal of Practical Medicine,2014,30(8):1231-1234.(in Chinese)
[24] FRANZÉN Å,PIEK E,WESTERMARK B,et al.Expression of transforming growth factor-β1,activin A and their receptors in thyroid follicle cells:Negative regulation of thyroid growth and function[J].Endocrinology,1999,140(9):4300-4310.
[25] ISLAM S S,MOKHTARI R B,HOUT Y E,et al.TGF-β1 induces EMT reprogramming of porcinebladder urothelial cells into collagen producing fibroblasts-like cells in a Smad2/Smad3-dependent manner[J].Journal of Cell Communication & Signaling,2014,8(1):39-58.
[26] LAMBA P,WANG Y S,OUSPENSKAIA T,et al.Activin A regulates porcine follicle-stimulating hormone beta-subunittran scription via cooperative actions of SMADs and FOXL2[J].Endocrinology,2010,151(11):5456-5467.
[27] GILCHRIST R B,RITTER L J.Differences in the participation of TGFB superfamily signalling pathways mediating porcine and murine cumulus cell expansion[J].Reproduction,2011,142(5):647-657.
[28] HUI L,GUO S,CAI L,et al.Lipopolysaccharide and heat stress impair the estradiol biosynthesis in granulosa cells via increase of HSP70 and inhibition of smad3 phosphorylation and nuclear translocation[J].Cellular Signalling,2016,30:130-141.
[29] ZHOU J,LIU J,PAN Z,et al.The let-7g microRNA promotes follicular granulosa cell apoptosis by targeting transforming growth factor-β type 1 receptor[J].Molecular & Cellular Endocrinology,2015,409:103-112.
[30] 崔连涛,丰艳妮,吕世腾,等.Smad3信号通路在卵母细胞体外成熟中的作用[J].中国畜牧杂志,2016,52(21):20-24. CUI L T,FENG Y N,LYU S T,et al.Effect of Smad3 signal pathway on oocytic meiotic in vitro maturation[J].Chinese Journal of Animal Science,2016,52(21):20-24.(in Chinese)
[31] 徐梦思,黄涛,刘丽娟,等.TGFβ-SMAD信号通路基因在梅山猪与杜洛克猪不同级别卵泡中的表达分析[J].家畜生态学报,2016,37(2):12-18. XU M S,HUANG T,LIU L J,et al.Expression patterns of gene of TGFβ-SMAD signaling pathway in Meishan and Duroc follicle of different sizes[J].Journal of Domestic Animal Ecology,2016,37(2):12-18.(in Chinese)
[32] 吕欣腾,王春光,吕世腾,等.Smad3基因在猪卵母细胞体外减数分裂成熟不同时期的表达[J].中国畜牧杂志,2014,50(1):25-29. LYU X T,WANG C G,LYU S T,et al.Expression of Smad3 gene during the meiotic maturation of porcine oocytes in vitro[J].Chinese Journal of Animal Science,2014,50(1):25-29.(in Chinese)
[33] 范觉鑫.大豆异黄酮对巴马香猪初情启动及卵泡发育的影响及其机制[D].长沙:湖南农业大学,2015. FANG J X.Effects of soybean isofloavones on onset of puberty and follicular development of bama miniature pigs[D].Changsha:Hunan Agricultural University,2015.(in Chinese)
[34] 阮井玲.猪Smad3、MyoD及GDF-8基因调控网络的研究[D].哈尔滨:东北农业大学,2008. RUAN J L.Study on porcine Smad3,MyoD and GDF-8 genes regulatory networks[D].Harbin:Northeast Agricultural University,2008.(in Chinese)
[35] SPICER L J,AAD P Y,ALLEN D T,et al.Growth differentiation factor 9(GDF9) stimulates proliferation and inhibits steroidogenesis by bovine theca cells:Influence of follicle size on responses to GDF9[J].Biology of Reproduction,2008,78(2):243-253.
[36] ZHANG L,NING Y,LI P,et al.Tissue expression analysis and characterization of Smad3 promoter in bovine myoblasts and preadipocytes[J].DNA & Cell Biology,2018,37(6):551-559.
[37] MARONI D,DAVIS J S.Transforming growth factor beta 1 stimulates profibrotic activities of luteal fibroblasts in cows[J].Biology of Reproduction,2012,87(5):517-527.
[38] ZHANG K,RAJPUT S K,LEE K B,et al.Evidence supporting a role for SMAD2/3 in bovine early embryonic development:Potential implications for embryotropic actions of follistatin[J].Biology of Reproduction,2015,93(4):86-92.
[39] 狄和双.TGF-β对奶牛乳腺细胞凋亡的影响及其机理研究[D].南京:南京农业大学,2008. DI H S.The effects of TGF-β1 on apoptosis of bovine mammary cell and its regulation mechanism[D].Nanjing:Nanjing Agricultural University,2008.(in Chinese)
[40] SHI T,PENG W,YAN J,et al.A novel 17 bp indel in the SMAD3 gene alters transcription level,contributing to phenotypic traits in Chinese cattle[J].Archives Animal Breeding,2016,59(1):151-157.
[41] LIU C,LI W,ZHANG X,et al.The critical role of myostatin in differentiation of sheep myoblasts[J].Biochemical & Biophysical Research Communications,2012,422(3):381-386.
[42] 梁青.IGF-I和TGF-β1对山羊SMSCs分化融合能力及相关基因表达的影响[D].雅安:四川农业大学,2013. LIANG Q.The effects of IGF-Ⅰ and TGF-β1 on the differentiation and fusion of the goat SMSCs and the expressions of genes[D].Ya'an:Sichuan Agricultural Uniersity,2013.(in Chinese)
[43] WANG Q Z,SU R,LV X Y,et al.Analysis of the spatiotemporal expression of major genes in the TGF-β/Smad signaling pathway and correlation analysis using Hu sheep muscle tissue[J].Genetics & Molecular Research,2016,15(2):15028133.
[44] GAO W,SU R,SUN W,et al.Temporal and spatial expression of Smads and their correlation with YAP1 expression in sheep[J].Genetics & Molecular Research,2016,15(3):15037715.
[45] 吐来力江·哈木太.MSTN/Smad信号通路与阿勒泰羊肌肉生长发育、产肉性能关联性的研究[D].乌鲁木齐:新疆农业大学,2014. TULAILIJIANG·HAMUTAI.The relevance of MSTN/Smad signaling pathways and muscle growth and meat performance relevance of Altai sheep[D].Urumqi:Xinjiang Agricultural University,2014.(in Chinese)
[46] 姚力丹.巴什拜羔羊MSTN/Smad信号通路基因表达、DNA甲基化与产肉性能关联性研究[D].乌鲁木齐:新疆农业大学,2016. YAO L D.The study of gene expression level in MSTN/Smad signaling pathways and its correlation with DNA methylation in Xinjiang Bashiby lamb[D].Urumqi:Xinjiang Agricultural University,2016.(in Chinese)
[47] 安外尔·热合曼.MSTN/Smad信号通路与吐鲁番黑羊肌肉生长发育、产肉性能关联性的研究[D].乌鲁木齐:新疆农业大学,2016. ANWAIER·REHEMAN.The relevance of MSTN/Smad signaling pathways and muscle growth and meat performance of Turpan Black sheep[D].Urumqi:Xinjiang Agricultural University,2016.(in Chinese)
[48] 刘育林.鸡Smad3的克隆表达及其与Myostatin关系的研究[D].哈尔滨:哈尔滨工业大学,2004. LIU Y L.Cloned and expression of chicken Smad3 and relationship with Myostatin[D].Harbin:Harbin Institute of Technology,2004.(in Chinese)
[49] LI X,MCFARLAND D C,VELLEMAN S G.Effect of Smad3-mediated transforming growth factor-beta1 signaling on satellite cell proliferation and differentiation in chickens[J].Poultry Science,2008,87(9):1823-1833.
[50] YE Y,LIN S,MU H,et al.Analysis of differentially expressed genes and signaling pathways related to intramuscular fat deposition in skeletal muscle of sex-linked dwarf chickens[J].Biomed Research International,2014,2014(7):724274.
[51] WHYTE J,GLOVER J,WOODCOCK M,et al.FGF,insulin,and SMAD signaling cooperate for avian primordial germ cell self-renewal[J].Stem Cell Reports,2015,5(6):1171-1182.
[52] 魏岳.边鸡MSTN基因、MyoD家族部分基因和Smad3基因多态性与生长和屠体性状的相关性分析以及表达的研究[D].扬州:扬州大学,2014. WEI Y.The polymorphism and expression of MSTN gene,part of MoyD gene family and Smad3 gene and their relationship with growth and slaughter performance in Bian chicken[D].Yangzhou:Yangzhou University,2014.(in Chinese)
[53] 林凯,虞德兵,解晓东,等.TGF-β/Smad信号通路在Follistatin调节鸭骨骼肌卫星细胞增殖过程中的作用机制[J].中国农业科学,2015,48(12):2460-2468. LIN K,YU D B,XIE X D,et al.The regulated mechanism of follistatin on the proliferation process of duck skeletal muscle satellite cell involved in TGF-β/Smad signaling pathway[J].Scientia Agricultura Sinica,2015,48(12):2460-2468.(in Chinese)
[54] SUGIYAMA K,OOISHI R,NISHINO Y,et al.Nucleotide sequence of canine Smad3[J].Biochemical Genetics,2010,48(3-4):202-207.
[55] BRISTOL S K,WOODRUFF T K.Follicle-restricted compartmentalization of transforming growth factor β superfamily ligands in the feline ovary[J].Biology of Reproduction,2004,70(3):846-859.
[56] SU Y Q,SUGIURA K,LI Q,et al.Mouse oocytes enable LH-induced maturation of the cumulus-oocyte complex via promoting EGF receptor-dependent signaling[J].Molecular Endocrinology,2010,24(6):1230-1239.
[57] 金玉洁,董静霞,刘玉霞,等.Smad3基因促进大鼠卵巢颗粒细胞增殖[J].解剖学报,2011,42(6):766-769. JIN Y J,DONG J X,LIU Y X,et al.Smad3 gene promoting proliferation of GCs in rats[J].Acta Anatomica Sinica,2011,42(6):766-769.(in Chinese)
[58] 申春艳,董静霞,徐健.Smad3促进大鼠卵巢颗粒细胞自噬[J].解剖学报,2014,45(1):109-113. SHEN C Y,DONG J X,XU J.Smad3 promotes the autophagy of granulosa cells in rats[J].Acta Anatomica Sinica,2014,45(1):109-113.(in Chinese)
[59] 王莹莹.Smad3敲除有效改善小鼠心脏移植排斥反应[D].杭州:浙江大学,2016. WANG Y Y.Deletion of SMAD3 improves cardiac allograft rejection in mice[D].Hangzhou:Zhejiang University,2016.

Application Research Progress of SMAD3 Gene in Livestock Production

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	GAO Shihua, WANG Fang, YIN Yexin, TAN Bi'e, YIN Yulong, CHEN Jiashun. Nutritional Value and Anti-nutrient Factor of Fermented Rapeseed Meal and Its Application in Animal Production [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2333-2341.
[2]	SONG Yue, SU Shengjie, ZHANG Fan, BAI Fan, DAI Lingli, WANG Na, WANG Dawei, YANG Qianwen, ZHAO Shihua, ZHANG Yuemei. Prokaryotic Expression and Polyclonal Antibody Preparation of Mannheimia haemolytica Truncated Leukotoxin [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2479-2486.
[3]	ZHANG Jingyi, CHEN Li, HUANG Siyang, CHEN Xiang, LIU Zongping, TONG Xishuai. Research Progress on Pathogenic Characteristics and Pathogenicity of Ehrlichia canis [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2023-2031.
[4]	XU Chenghui, ZHANG Xumei, YANG Tong, LI Jiahui, SUN Yawei, SHI Huijun, FU Qiang, YANG Li. Molecular Mechanism of Leonurine in the Treatment of Intestinal Inflammation Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2103-2113.
[5]	CHEN Tianbao, WANG Yani, LIU Baoling, WANG Gang, WANG Xiaohu, LIU Xuhui, CAI Rujian, HE Dongsheng. Research Progress on the Anti-Porcine Reproductive and Respiratory Syndrome Virus Effect and Mechanism of Traditional Chinese Medicine [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 2114-2129.
[6]	YAO Kang, CAO Shuting, JIANG Zongyong, WANG Li. The Research Progress of Lysine Application and Requirement in Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1364-1374.
[7]	GUO Bingyu, LI Li, LI Chen, KONG Xianghui. Role and Molecular Mechanism of Mpeg1 in Pathogen Clearance [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1584-1592.
[8]	DOU Jiahong, WANG Ziying, YANG Juan, ZHOU Weiwei, ZHANG Tongcun, HE Hongpeng, DAI Xiaofeng, LI Xiumei. Analysis of the Active Ingredients and Mechanism of Radix Paeoniae Rubra Antioxidative Stress Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(3): 1229-1240.
[9]	QIN Zhiyun, JIANG Huaizhi. An Overview of Research on Skin Hair Follicle Development and Regulatory Mechanism in Sheep During the Fetal Period [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 638-646.
[10]	HAN Guorui, XIAO Xiaoyue, ZHANG Yang, LI Yanhua, CHEN Xueying, WANG Xiumin, QIN Junjie, LIU Yanyan. Mechanism of Gui Qi Yimu Oral Liquid in the Treatment of Sus scrofa Qi and Blood Two Deficiency Syndrome Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 722-733.
[11]	MENG Yingwen, LI Yuehua, SHA Zhou, LI Chenyu, GONG Youquan, DONG Yaqin, WEI Rong, ZOU Fengcai, NI Bo. Screening of the Natural Products Against Senecavirus A and Study on Its Mechanism of Antagonism [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 734-744.
[12]	WANG Wei, LI Chunzhu, WANG Shasha, SANG Rui, GE Bingjie, LI Chunting, ZHAO Xin, LIU Xinman, YU Minghong, ZHANG Xuemei. Study on the Protective Mechanism of Traditional Chinese Medicine Combined with Probiotics on Diarrhea Caused by E.coli in Mice [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 779-788.
[13]	LIU Lin, WU Baoqing, GUO Xiaoyin, YU Wenhui, TIAN Lang. Study on Bacteriostatic Action of Aqueous Extract of Granati pericarpium Against Multi-drug Resistant Escherichia coli of Swine [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 328-340.
[14]	LIU Hongying, WANG Jingyu, CUI Zhenzhen, MA Qingxia, WANG Tingting, LI Jianming, SHI Kun, GONG Qinglong, DU Rui, LENG Xue. Research Progress on Immune Adjuvant Effect and Related Mechanism of Active Ingredients of Traditional Chinese Medicine on Animal Vaccines [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 390-397.
[15]	ZHANG Zufeng, ZHANG Yuxin, SUN Yuelong, ZHENG Wei, LI Xiumei. Study on Mechanism of Hawthorn in Regulating Oxidative Stress Based on Network Pharmacology and Molecular Docking [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 408-420.