牛主要抗病候选基因的研究进展

doi:10.16431/j.cnki.1671-7236.2018.07.023

Abstract

Abstract:

In this paper,the research progress of immune-related partial resistance genes (MHC,Nramp1,MBL,TLR and IFN) in cattle at home and abroad are briefly reviewed.Because of the relationship between the disease resistance genes of cattle and their own disease resistance and immunity,it is very meaningful to study the related resistance genes to improve the autoimmunity of cattle and to breed the fine offspring.This article focuses on the domestic and foreign study progress on the candidate resistance genes (Nramp 1,MHC,MBL,TLR and IFN) to certain diseases in cattle and whether it can be used for future generations of breeding molecular markers,such as MHC is closely related to dairy cow's mastitis;The CC genotype in the 1760 C>T mutation of TLR4 gene in cattle can be used as a molecular marker in the screening of resistance to mastitis in dairy cows.We believe that the study of these disease-resistance genes can give us a deeper understanding of the disease-resistant mechanism.At the same time, advanced techniques such as molecular markers and genetic engineering can be used to breed disease-resistant offspring,and the application of anti-disease genes in breeding will be the main direction of studying disease resistance and immunity in the future.

Key words: cattle; disease-resistant candidate genes; research progress

CLC Number:

S813.2

SUN Hongyu, SUOLANG Sizhu, XU Yefen, NIU Jiaqiang, YAO Yilong, ZHANG Rudan, WANG Dongjing. Research Progress of Major Disease Resistance Candidate Genes in Cattle[J]. , 2018, 45(7): 1912-1918.

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Research Progress of Major Disease Resistance Candidate Genes in Cattle

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