磺胺类药物滥用诱导宿主精神行为学变化及其机制探讨

doi:10.16431/j.cnki.1671-7236.2018.06.038

Abstract

Abstract:

Sulfonamides(SAs) are widely used in the prevention and treatment of foodborne animal diseases,and also for the treatment of human diseases.The abuse of sulfonamides can lead to a large number of residues in food and the environment,and ultimately enter into human body,causing damage of human health.The unreasonable use of SAs first leads to environmental hazards and further harms people's health,especially with neurotoxicity that induced host behavioral changes.This article summarized the current status of environmental and food contamination by SAs abuse,and its general damage such as blood system damage,liver and kidney toxicity.Emphasis is placed on the effects of SAs exposure on host psycho-behavioral changes including anxiety,depression and cognitive impairment.In addition,we discussed the related mechanisms such as sepiapterin reductase,mTOR signal and carbonic anhydrase.

Key words: sulfonamides; residues; mental behavior

CLC Number:

S859.796

ZHANG Qiang, YAO Huiyuan, WANG Haiqing, ZHONG Xingguo, WU Mengshui, MENG Feiyue. Study on the Change of Mental Behavior Induced by Sulfonamides and Its Mechanism[J]. , 2018, 45(6): 1722-1729.

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Study on the Change of Mental Behavior Induced by Sulfonamides and Its Mechanism

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