SIGIRR对IL-1R/TLRs信号通路的负性调控作用研究进展

doi:10.16431/j.cnki.1671-7236.2016.10.019

Abstract

Abstract:

Single immunoglobulin IL-1 related receptor (SIGIRR) is a member of TIR superfamily.Recent evidences suggested that it could negatively modulate ILRs/TLRs-mediated innate immune response,and in particular its important role focused from infectious and intestinal inflammation to autoimmunity or cancer-related inflammation had been illuminated.Here,we summarized our current understanding of the expression patterns of SIGIRR gene and protein in different specises including human,mouse and bovine,its downregulate function of the IL-1/TLRs singal pathway and specific negative regulation mechanism ascribed to its structure specificity,and also its elaborate regulating process related to the occurrence and development of different pathogen condition.And then it can not only provide theoretical references for clinical inflammatory related disease,but also broaden the application scope of SIGIRR gene in the treatment of animal diseases.

Key words: SIGIRR; TLRs; signal path; negative regulation

CLC Number:

Q257

ZHOU Qiu-ge, LIU Chang, LIU Yu-hui, LAI Jin-lun, CHEN Ying-yu, GUO Ai-zhen, HU Chang-min. Research Progress on the Negative Regulatory Function of SIGIRR to IL-1R/TLRs Signal Pathway[J]. , 2016, 43(10): 2640-2647.

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Research Progress on the Negative Regulatory Function of SIGIRR to IL-1R/TLRs Signal Pathway

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