猪圆环病毒2型基因组DNA的结构与功能研究进展

doi:10.16431/j.cnki.1671-7236.2016.05.008

Abstract

Abstract: Porcine circovirus type 2 (PCV2) is a disease caused by porcine circovirus, which can damage the host's immune system and exacerbate the clinical symptoms of many bacterial and viral infections.It has caused increasingly larger losses in the pig industry wordwide.The genomic DNA of PCV2 contains 11 open reading frames (ORFs) and at least seven potential ORFs-encoding proteins larger than 5 ku.However, only five virally encoded proteins, including Rep, Rep', Cap, ORF3 and ORF4, had been identified in PCV2 replication.In this review, we discussed the progress on structure and function of genomic DNA of PCV2 in order to provide insight into the scientific basis of the pathogenesis of PCV2 and prevent its infection.

Key words: porcine circovirus type 2; genomic DNA; open reading frames; virally encoded proteins

CLC Number:

S852.65

ZHAO Yan, YU Zheng-jun. Advances on Structure and Function of Genomic DNA of Porcine Circovirus Type 2[J]. , 2016, 43(5): 1176-1181.

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Advances on Structure and Function of Genomic DNA of Porcine Circovirus Type 2

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