›› 2015, Vol. 42 ›› Issue (3): 757-763.doi: 10.11843/j.issn.1671-7236.2015.03.039

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Research Progress on Infection Mechanism and Diagnostic Methods of Canine Distemper Virus

WANG Xi-xi, WANG Feng-xue, CHENG Shi-peng, WEN Yong-jun   

  1. State Key Laboratory of Special Economic Animal Molecular Biology, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China
  • Received:2014-09-05 Online:2015-03-20 Published:2015-03-30

Abstract: The author introduces the roles of six structural proteins (N,P,L,F,H and M proteins) of canine distemper virus in the invasion and propagation in host cell.We briefly describe the infection and spread mechanisms of canine distemper virus in animals,while cell receptors SLAM and PVRL4 explain viral tropism.We describe the clinical diagnosis,animal experiment,serological methods,nucleic acid diagnostic methods of canine distemper virus and their advantages and disadvantages.This article can help to understand infection mechanism and different diagnostic methods of canine distemper virus,which contribute to find new ways to control the spread of canine distemper virus.

Key words: canine distemper virus; structural protein; infection mechanism; diagnose

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