布鲁氏菌胞内存活机制与巨噬细胞极化关系研究进展

doi:10.16431/j.cnki.1671-7236.2018.04.031

Abstract

Abstract:

Brucella is a facultative intracellular parasitic bacterium.It has strong pathogenicity and often causes chronic persistent infections,although there is no typical virulence factor.Brucellosis is listed as a serious zoonosis in the world and directly causes serious losses to the economic income of animal husbandry.It not only hinders social development,but also threatens human health and public health security.The target cells of Brucella is mainly macrophages,it develops a higher strategy to escape the immune cell killing by the immune system,even multiply within the cell and weakens the function of macrophages.The killing and antigen presenting functions of macrophages are partially lost,thereby establishing long-term persistent infection in host cells.This article focuses on the mechanism of Brucella cell viability,and analyzes the regulation of different polarization types of macrophages in the process of Brucella infection,and the role of related inflammatory pathways in the development of inflammation.Brucella intracellular survival not only accommodates the different immune microenvironments during persistent infection,but also accommodates the differences in nutrient availability of target cells during infection.It confirms the key role of immune evasion and interaction with host cell metabolism during chronic infection.It is also explained that NF-κB pathway is a key factor in regulating the balance status of M1/M2 subtype macrophages.In conclusion,the continuous infection of Brucella in host cells is a huge challenge for domestic and foreign scholars.The mechanism and pathogenesis of immune evasion in Brucella need to be studied more specifically.

Key words: Brucella; infection mechanism; intracellular survival; macrophage polarization

CLC Number:

S852.61⁺4

YI Jihai, WANG Yueli, WANG Zhen, CHEN Chuangfu. Research Progress on the Relationship Between Intracellular Survival Mechanism of Brucella and Macropohage Polarization[J]. , 2018, 45(4): 1082-1088.

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Research Progress on the Relationship Between Intracellular Survival Mechanism of Brucella and Macropohage Polarization

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