《中国畜牧兽医》---唯一指定的官方网站 ›› 2016, Vol. 43 ›› Issue (5): 1374-1378.doi: 10.16431/j.cnki.1671-7236.2016.05.038

• 疾病防治 • 上一篇    下一篇

鸡传染性法氏囊病免疫复合物疫苗对新城疫La Sota疫苗免疫效果的影响

章振华, 李林, 张建伟, 沈佳, 史爱华, 黄凤军, 郑小兰, 姜北宇   

  1. 北京市农林科学院畜牧兽医研究所, 畜禽疫病防控技术北京市重点实验室, 北京 100097
  • 收稿日期:2015-10-15 出版日期:2016-05-20 发布日期:2016-05-23
  • 通讯作者: 姜北宇 E-mail:jby512@sina.com
  • 作者简介:章振华(1980-),男,江西南昌人,博士,副研究员,研究方向:禽病学,E-mail:zhangzhenhua304@163.com;李林(1962-),女,北京人,学士,高级兽医师,研究方向:禽病学,E-mail:ll2788@sina.com
  • 基金资助:

    国家自然科学基金(31402230);北京市自然科学基金(6132014);北京市农林科学院创新能力建设项目(KJCX20140413)

Effect of the Immunity Efficacy of IBD Immune Complex Vaccine on ND La Sota Vaccine

ZHANG Zhen-hua, LI Lin, ZHANG Jian-wei, SHEN Jia, SHI Ai-hua, HUANG Feng-jun, ZHENG Xiao-lan, JIANG Bei-yu   

  1. Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Municipal Academy of Agriculture and Forestry, Beijing 100097, China
  • Received:2015-10-15 Online:2016-05-20 Published:2016-05-23

摘要: 用鸡传染性法氏囊病(IBD)免疫复合物疫苗免疫1日龄SPF雏鸡和普通京粉雏鸡,间隔1、2周后免疫新城疫La Sota疫苗,以单独免疫新城疫La Sota疫苗为对照,免疫后2、3、4和5周对各组鸡采血测定新城疫HI效价,并在免疫5周后用新城疫强毒攻击,计算各组保护率。结果显示,1日龄时首免IBD免疫复合物疫苗间隔不同时间再免疫新城疫La Sota疫苗,与单独免疫新城疫La Sota疫苗相比,新城疫HI抗体水平均无显著差异(P>0.05)。证明IBD免疫复合物疫苗在SPF雏鸡和普通雏鸡上对新城疫La Sota疫苗免疫均无免疫抑制作用。

关键词: IBD免疫复合物疫苗; 新城疫La Sota疫苗; 免疫抑制

Abstract: 1-day-old SPF chickens and commercial Jingfen chickens were vaccinated with IBD immune complex(IC) vaccine, NDV La Sota vaccine were inoculated simultaneously every one week and every two weeks.NDV La Sota immunization alone was as the control group.At the 2nd, 3rd, 4th and 5th week post inoculation, blood samples were taken and the ND HI antibody were tested.Experimental chickens were challenged with high virulent NDV at the 5th week post inoculation, the protective rate of each group was calculated.The results showed the ND HI antibody were not significant different in the combined immunization of IBD IC vaccine priming and NDV La Sota vaccine boost and NDV La Sota vaccine alone immunization (P>0.05).The results indicated that IBD IC vaccine has no immunosuppression on NDV La Sota vaccine in SPF chickens and commercial Jingfen chickens.

Key words: IBD immune complex vaccine; ND La Sota vaccine; immunosuppression

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