自噬调控猪脂肪生成的研究进展

doi:10.16431/j.cnki.1671-7236.2024.12.020

摘要/Abstract

摘要： 脂肪组织是动物机体的能量储存站，也是重要的内分泌器官。脂肪过度沉积造成的肥胖会带来一系列的代谢性疾病，如脂肪肝、心血管疾病、胰岛素抵抗等。同样地，猪脂肪的生成影响着猪的抗病力、繁殖性能、肉品质、生产效率等性状，这些性状影响着生猪生产的经济效益。成熟的脂肪细胞是由间充质干细胞经前脂肪细胞分化得到的，这个过程中有许多信号通路和转录因子参与，而自噬通常是分解代谢机体中冗余成分最主要的手段，参与维持着机体内稳态。自噬和脂肪生成之间有密切的联系，通常脂肪生成活跃时伴随着自噬水平的升高；而自噬过程受损也伴随着脂肪生成的抑制。在自噬活动中，有许多相关的转录因子和信号通路也参与调控猪脂肪的生成；而在猪脂肪生成的过程中，许多转录调控因子也与自噬关系密切。作者通过总结最新报道的与自噬调控脂肪生成相关的转录因子和信号通路，阐述自噬参与猪脂肪生成调控的研究进展，为猪营养调控和肉质育种提供了全新的思路和靶点。

关键词: 猪; 自噬; 脂肪生成; 转录因子; 调控

Abstract: Adipose tissue is an energy storage station in the animal organism and an important endocrine organ.Obesity caused by excessive fat deposition brings about a series of metabolic diseases,such as fatty liver,cardiovascular disease and insulin resistance.Similarly,porcine adipogenesis influences traits such as disease resistance,reproductive performance,meat quality and productivity,which affect the economic efficiency of hog production.Mature adipocytes are obtained by differentiation of mesenchymal stem cells,a process in which many signaling pathways and transcription factors are involved via preadipocytes.Autophagy is usually the most important means of catabolizing redundant components of the organism and is involved in the maintenance of homeostasis.There is a close link between autophagy and adipogenesis,active adipogenesis is accompanied by elevated levels of autophagy,and impaired autophagy is accompanied by suppressed adipogenesis.There are many related transcription factors and signaling pathways that regulate porcine adipogenesis during autophagic activities,and many transcription factors are involved in the process of porcine adipogenesis.By summarizing the newly reported transcription factors and signaling pathways related to autophagy regulation of adipogenesis,the author elaborates the research progress on autophagy involved in the regulation of porcine adipogenesis,which provides a new idea and target point for the regulation of porcine nutrition and meat quality breeding.

Key words: pigs; autophagy; adipogenesis; transcription factor; regulation

中图分类号:

S852.23

洪纯, 朱向星, 李新明, 黄秋艳, 刘文华, 杜宗亮, 唐冬生, 王塑天. 自噬调控猪脂肪生成的研究进展[J]. 中国畜牧兽医, 2024, 51(12): 5325-5334.

HONG Chun, ZHU Xiangxing, LI Xinming, HUANG Qiuyan, LIU Wenhua, DU Zongliang, TANG Dongsheng, WANG Sutian. Progress on Autophagy Regulation of Porcine Adipogenesis[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(12): 5325-5334.

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