猪繁殖与呼吸综合征病毒诱导的炎症反应及抗炎药物研究进展

doi:10.16431/j.cnki.1671-7236.2024.08.030

摘要/Abstract

摘要： 猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome,PRRS)是由猪繁殖与呼吸综合征病毒(Porcine reproductive and respiratory syndrome virus,PRRSV)引起的母猪严重繁殖障碍与仔猪呼吸困难的一种全球性疾病。感染PRRSV所引起疾病的严重程度与病毒载量和体内产生的细胞因子有关。PRRSV通过自身编码的结构蛋白和非结构蛋白激活炎症信号通路,导致大量细胞因子、趋化因子释放从而诱导炎症反应,但过度炎症反应特别是细胞因子风暴可能导致严重的组织损伤,导致病情加剧。因此通过抑制PRRSV引起的炎症应答可能是有效预防和控制PRRS的主要策略。目前常用的抗炎药物包括重组干扰素、非甾体抗炎药(NSAID)和类固醇等,传统的中药制剂也被证实对PRRS有一定治疗效果。然而PRRSV感染诱导炎症反应的具体条件、程度和机制以及抗炎药物作用尚未清楚。笔者拟对PRRSV诱导的炎症反应及其作用机制,以及相关抗炎药物的开发应用进行综述,以期为PRRS的预防和控制提供新的思路。

关键词: 猪繁殖与呼吸综合征病毒(PRRSV); 炎症反应; 细胞因子; 抗炎药物

Abstract: Porcine reproductive and respiratory syndrome (PRRS) is a global disease caused by Porcine reproductive and respiratory syndrome virus (PRRSV),which causes severe reproductive disorders in sows and respiratory distress in piglets.The severity of the disease caused by PRRSV infection is related to the viral load and the cytokines produced in the body.PRRSV activates inflammatory signaling pathways through structural and non-structural proteins encoded by itself,resulting in the release of a large number of cytokines and chemokines to induce inflammatory responses,but excessive inflammatory responses,especially cytokine storms,may lead to serious tissue damage and aggravate the disease.Therefore,inhibiting the inflammation caused by PRRSV may be the main strategy to effectively prevent and control PRRS.At present,the commonly used anti-inflammatory drugs include recombinant interferon,non-steroidal anti-inflammatory drugs (NSAID) and steroids,etc.Traditional Chinese medicine preparations have also been confirmed to have a certain therapeutic effect on PRRS.However,the conditions,degree and mechanism of inflammation induced by PRRSV infection and the role of anti-inflammatory drugs are not yet clear.The author intends to review the inflammatory response induced by PRRSV and its mechanism of action,as well as the development and application of related anti-inflammatory drugs,in order to provide new ideas for the prevention and control of PRRS.

Key words: Porcine reproductive and respiratory syndrome virus (PRRSV); inflammatory response; cytokines; anti-inflammatory drugs

中图分类号:

S852.65^＋1

乔常宏, 陈晶, 罗琴, 刘宝玲, 何振文, 刘丁语, 陈翔宇, 王晓虎, 王刚, 白挨泉, 蔡汝健. 猪繁殖与呼吸综合征病毒诱导的炎症反应及抗炎药物研究进展[J]. 中国畜牧兽医, 2024, 51(8): 3528-3539.

QIAO Changhong, CHEN Jing, LUO Qin, LIU Baoling, HE Zhenwen, LIU Dingyu, CHEN Xiangyu, WANG Xiaohu, WANG Gang, BAI Aiquan, CAI Rujian. Advances in Inflammation Induced by Porcine Reproductive and Respiratory Syndrome Virus and Anti-inflammatory Drugs[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(8): 3528-3539.

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