中药有效成分对动物疫苗的免疫佐剂效果及相关机理研究进展

doi:10.16431/j.cnki.1671-7236.2023.01.039

摘要/Abstract

摘要： 佐剂作为疫苗的重要组成部分，其自身的安全性及对疫苗的免疫增强效果受到广泛重视。动物疫苗佐剂种类较多，包括铝佐剂、油乳佐剂和脂质体佐剂等。但由于可应用的佐剂有限，疫苗的需求量增大，因此寻求更加安全有效的疫苗佐剂成为新的研究热潮。中药具有易获取、毒性低和免疫活性强等特点，有潜力成为新型疫苗佐剂。笔者对中药有效成分的佐剂活性、联合疫苗后的免疫调节效果及作用机制进行综述，阐明中药有效成分作为动物疫苗佐剂的可能性及研究进展，为新型佐剂的研制提供理论依据。

关键词: 中药; 动物疫苗; 佐剂; 作用机理

Abstract: As an important part of vaccines, adjuvants have received extensive attention for their safety and their immune-enhancing effects on vaccines.There are many kinds of adjuvants for animal vaccines, including aluminum adjuvant, oil emulsion adjuvant and liposome adjuvant.Due to the limited adjuvants available and the increasing demand for vaccines, the search for safer and more effective vaccine adjuvants has become a new upsurge.Traditional Chinese medicine has the characteristics of easy access, low toxicity and strong immune activity.It has the potential to become a new vaccine adjuvant.This article reviewed the adjuvant activity of the active ingredients of traditional Chinese medicine, the immune regulatory effect and the mechanism of action after the combined vaccine, expounded on the possibility and research progress of the active ingredients of traditional Chinese medicine as adjuvants for animal vaccines, and provided a theoretical basis for the development of new adjuvants.

Key words: traditional Chinese medicine; animal vaccines; adjuvant; mechanism of action

中图分类号:

S853.7

刘宏莹, 王婧瑜, 崔珍珍, 马青霞, 汪婷婷, 李健明, 时坤, 宫庆龙, 杜锐, 冷雪. 中药有效成分对动物疫苗的免疫佐剂效果及相关机理研究进展[J]. 中国畜牧兽医, 2023, 50(1): 390-397.

LIU Hongying, WANG Jingyu, CUI Zhenzhen, MA Qingxia, WANG Tingting, LI Jianming, SHI Kun, GONG Qinglong, DU Rui, LENG Xue. Research Progress on Immune Adjuvant Effect and Related Mechanism of Active Ingredients of Traditional Chinese Medicine on Animal Vaccines[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(1): 390-397.

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