非编码RNA在动物肌纤维类型转化中的调控作用研究进展

doi:10.16431/j.cnki.1671-7236.2024.03.025

摘要/Abstract

摘要： 非编码RNA(non-coding RNA,ncRNA)是由基因组转录而成的不编码蛋白质的RNA分子,包括微小RNA(microRNA,miRNA)、长链非编码RNA(long non-coding RNA,lncRNA)、环状RNA(circular RNA,circRNA)和未知功能的RNA。ncRNA在细胞内发挥多种调控功能,如参与基因表达调控、DNA修复、细胞分裂等生物学过程。ncRNA可以靶向调控基因转录从而调节肌肉生长发育。肌纤维是构成肌肉的基本结构单元,不同生物的肌纤维类型作用不同,且不同肌纤维类型肉的颜色、口感、营养成分和保水性等方面都有所差异。因此,揭示肌纤维类型转化机理对于提高肉品质具有重要意义。ncRNA作为肌纤维类型转化中的关键调节因子,是不可忽视的研究方面。作者以miRNA、lncRNA、circRNA 3种ncRNA为主,综述了ncRNA和肌纤维类型的概念及ncRNA调控肌纤维类型转化的研究现状,以期为ncRNA应用于畜禽肉品质的改良提供重要参考。

关键词: ncRNA; miRNA; lncRNA; circRNA; 肌纤维类型转化

Abstract: Non-coding RNA (ncRNA) is an RNA molecule transcribed from the genome that does not code for proteins,including microRNA (miRNA),long non-coding RNA (lncRNA),circular RNA (circRNA) and RNA of unknown function.The function of ncRNA is to perform various regulatory functions in cells,such as participating in gene expression regulation,DNA repair,cell division and other biological processes.ncRNA can target and regulate gene transcription which in turn modulates muscle growth and development.Myofibers are the basic structural unit of muscle,and different muscle fiber-type of organisms act differently.Moreover,meat comprising different muscle fiber types varies in color,texture,nutrient content and water retention.Hence,it is significant to conduct research on muscle fiber-type conversion to achieve improved meat quality.Whereas,as a critical regulator in the transformation of myofiber types,ncRNA is a research hotspot that can not be ignored.In this paper,based on three kinds of ncRNA,which are miRNA,lncRNA and circRNA,the authors reviewed the concepts of ncRNA and muscle fiber-type and the current research status of ncRNA regulating the muscle fiber-type conversion,in order to provide important references for the application of ncRNA in improving the meat quality of livestock and poultry.

Key words: ncRNA; miRNA; lncRNA; circRNA; muscle fiber-type conversion

中图分类号:

S852.21

陈博赫, 刘付穗, 喻宗岗, 王开明, 刘晓林, 易磊, 马海明. 非编码RNA在动物肌纤维类型转化中的调控作用研究进展[J]. 中国畜牧兽医, 2024, 51(3): 1132-1141.

CHEN Bohe, LIUFU Sui, YU Zonggang, WANG Kaiming, LIU Xiaolin, YI Lei, MA Haiming. Research Progress on the Regulation of Non-coding RNA in Muscle Fiber-type Conversion in Animals[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(3): 1132-1141.

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