细胞自噬与胞内病原体感染相互作用的研究进展

中国畜牧兽医 ›› 2014, Vol. 41 ›› Issue (9): 265-268.

细胞自噬与胞内病原体感染相互作用的研究进展

李静^1,2, 李小康^1,2, 何雷^1,2, 贾艳艳^1,2, 余祖华^1,2, 郁川^1,2, 陈松彪^1,2, 颜云飞^1,2, 张春杰^1,2, 程相朝^1,2, 李银聚^1,2, 吴庭才^1,2

1. 河南省动物疫病与公共安全院士工作站, 河南洛阳 471003;
2. 河南科技大学动物疫病与公共卫生重点实验室, 河南洛阳 471003

修回日期:2014-07-16 出版日期:2014-09-20 发布日期:2014-09-24
通讯作者: 程相朝 E-mail:chengxch@126.com
作者简介:李静（1982- ），女，河南人，博士，讲师，研究方向：动物病理学。
基金资助:
河南科技大学博士启动基金（09001580）；河南科技大学青年科学基金（13000820）。

Research Progress on the Interaction between Cell Autophagy and Intracellular Pathogen Infection

LI Jing^1,2, LI Xiao-kang^1,2, HE Lei^1,2, JIA Yan-yan^1,2, YU Zu-hua^1,2, YU Chuan^1,2, CHEN Song-biao^1,2, YAN Yun-fei^1,2, ZHANG Chun-jie^1,2, CHENG Xiang-chao^1,2, LI Yin-ju^1,2, WU Ting-cai^1,2

1. Animal Disease and Public Safety Academician Workstation of Henan Province, Luoyang 471003, China;
2. Key Laboratory of Animal Disease and Public Health, Henan University of Science and Technology, Luoyang 471003, China

Revised:2014-07-16 Online:2014-09-20 Published:2014-09-24

摘要/Abstract

摘要： 作为先天性免疫的一部分，自噬在胞内病原体感染过程中发挥着“双刃剑”的作用，一方面自噬可抑制、消灭胞内感染病原体，保护机体免受病原体的侵害；另一方面一些胞内病原体可抑制、阻断自噬的发生或成熟，甚至利用自噬逃避机体的免疫机制，利于其在体内的存活、增殖。作者从细胞自噬与胞内病原体之间的相互关系着手，对自噬在胞内病原体感染过程中所发挥的作用进行综述。

关键词: 细胞; 自噬; 病原体; 感染

Abstract: As a part of the congenital immune, autophagy plays a "double-edged sword" role in the process of intracellular pathogen infection. On the one hand, autophagy could suppress and eliminate the infection of intracellular pathogens, protect the body from the invader; on the other hand, some intracellular pathogens could inhibit, block the occurrence or mature of autophagy, or autophagy is even used to escape the immune mechanism, it is conducive for the proliferation and survival of intracellular pathogens in the body.The author reviewed the interactions between autophagy and intracellular pathogen, and the function of autophagy played in intracellular pathogen infection.

Key words: cell; autophagy; pathogen; infection

中图分类号:

S852.4⁺2

李静, 李小康, 何雷, 贾艳艳, 余祖华, 郁川, 陈松彪, 颜云飞, 张春杰, 程相朝, 李银聚, 吴庭才. 细胞自噬与胞内病原体感染相互作用的研究进展[J]. 中国畜牧兽医, 2014, 41(9): 265-268.

LI Jing, LI Xiao-kang, HE Lei, JIA Yan-yan, YU Zu-hua, YU Chuan, CHEN Song-biao, YAN Yun-fei, ZHANG Chun-jie, CHENG Xiang-chao, LI Yin-ju, WU Ting-cai. Research Progress on the Interaction between Cell Autophagy and Intracellular Pathogen Infection[J]. , 2014, 41(9): 265-268.

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