威尔姆氏瘤基因1对肾脏和性腺发育影响的研究进展

中国畜牧兽医

威尔姆氏瘤基因1对肾脏和性腺发育影响的研究进展

安培培，李春义

中国农业科学院特产研究所，特种经济动物分子生物学国家重点实验室，吉林长春 130112

修回日期:2014-03-24 出版日期:2014-07-20 发布日期:2014-08-21
通讯作者: 李春义，男，研究员，博士生导师，主要从事动物干细胞研究。E-mail：lichunyi1959@163.com
作者简介:安培培（1983—），女，河北人，博士，助理研究员，从事动物克隆与干细胞方面的研究。
基金资助:
国家863课题（2011AA100603）；国家自然科学基金（31170950）。

Research Progress on the Effects of Wilms Tumor Gene 1 on the Development of Kidney and Gonads

AN Pei-pei, LI Chun-yi

State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Animal and Plant Sciences of CAAS, Changchun 130112, China

Revised:2014-03-24 Online:2014-07-20 Published:2014-08-21

摘要/Abstract

摘要： 威尔姆氏瘤基因1（Wilms tumor gene 1，WT1）是与威尔姆氏瘤相关的，在威尔姆氏瘤中发生功能失活的基因。同时，WT1基因编码的锌指蛋白在调节不同组织和不同类型细胞的正常分化中又扮演着很重要的角色。研究发现，WT1基因敲除小鼠会出现无肾脏、性腺缺失及视网膜畸形等症状。同时，在正常性别发育过程中，WT1基因还可维持雄性体征。因此，在发育过程中，WT1基因与肾脏及性腺细胞的存活及分化密切相关，但其具体机制需进一步研究。

关键词:

威尔姆氏瘤基因1; 肾脏; 性腺

Abstract: The Wilms tumor gene 1(WT1) is first found to be inactivated in Wilms toumor. It encodes zinc finger proteins which act as tumor suppressor and play important roles in the development of the genitourinary system and several other tissues.WT1-null mice do not have kidneys and gonads and have abnormal retinas.In addition, WT1 is also required for normal male sex determination in the context of urogenital development. Hence, WT1 is required for both kidney and gonads development. But the mechanisms underlying these phenotypic abnormalities are largely unknown.

Key words:

Wilms tumor gene 1; kidney; gonads

安培培，李春义. 威尔姆氏瘤基因1对肾脏和性腺发育影响的研究进展[J]. 中国畜牧兽医.

AN Pei-pei, LI Chun-yi. Research Progress on the Effects of Wilms Tumor Gene 1 on the Development of Kidney and Gonads[J]. .

参考文献

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