细胞分化的甲基化调控及其分子机理

中国畜牧兽医

细胞分化的甲基化调控及其分子机理

冀斌，孙亭亭，陈培富

（云南农业大学动物科学技术学院，云南昆明 650201）

收稿日期:2013-09-09 出版日期:2014-03-20 发布日期:2014-05-15
通讯作者: 陈培富，副教授，研究方向：动物微生物与免疫学。E-mail：cltwins2003@163.com
作者简介:冀斌（1985—），男，山西人，硕士生，研究方向：动物微生物与免疫学。
基金资助:
国家自然科学基金（31260516、31060130）。

The Molecular Mechanisms Underlying Methylation Intervention in the Cell Differentiation

JI Bin, SUN Ting-ting, CHEN Pei-fu

（College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China）

Received:2013-09-09 Online:2014-03-20 Published:2014-05-15

摘要/Abstract

摘要： 长期以来，对细胞分化过程的研究，尤其是对干细胞及其谱系的功能差异分析，主要集中在基因的转录水平调控。然而，越来越多的研究发现，DNA的甲基化、染色质重塑、基因组印记、染色体失活、非编码RNA作用等表观遗传学机制对哺乳动物发育、胚胎细胞分化及癌细胞增殖过程发挥着重要的作用。其中以DNA甲基化这种形式最为常见。作者就DNA甲基化对影响转录、分子调控、神经元发育、遗传等方面的最新研究成果进行综述。

关键词: 表观遗传; 甲基化; 分子机制; 细胞分化

Abstract: In the long period of time, the research of cell differentiation process, especially for lineages of stem cells and the difference of their function, mainly focused on the regulation of gene transcription level. However, as increasing numbers of researches indicated that epigenetic mechanism （DNA methylation, chromatin remodeling, genomic imprinting, chromosome inactivation, non-coding RNA, etc.） has significant impact on the mammalian development, embryonic cells differentiation and proliferation of cancer cells, in which DNA methylation is the most common form. In this paper, research shows how DNA methelation impacts on transcription of DNA, molecular regulation, neuronal development and genetic.

Key words: epigenetic; methylation; molecular mechanisms; cell differentiation

冀斌，孙亭亭，陈培富. 细胞分化的甲基化调控及其分子机理[J]. 中国畜牧兽医.

JI Bin, SUN Ting-ting, CHEN Pei-fu. The Molecular Mechanisms Underlying Methylation Intervention in the Cell Differentiation[J]. .

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