黄芩苷对动物肠道保护作用的研究进展

doi:10.16431/j.cnki.1671-7236.2024.02.043

摘要/Abstract

摘要： 黄芩苷是唇形科植物黄芩根部提取出的一种黄酮类活性物质,在碱性环境下,黄芩苷化学性质不稳定,其分子结构中的苷键易水解、邻二酚羟基易氧化。黄芩苷分子结构中糖基的存在,导致其几乎不溶于水,这使其在临床上的应用受到限制。黄芩苷在肠道中不易吸收,但在肠道微生物产生的β-葡萄糖醛酸酶的作用下,其糖基被去除,转化为更易被肠道吸收的黄芩素。黄芩素在动物体内发生葡萄糖醛酸化、葡萄糖化、甲基化和水解等代谢过程,代谢物主要随胆汁或尿液排出体外。药理学研究发现,黄芩苷具有抗炎、抗菌、抗病毒、抗肿瘤和抗肠道损伤等药理活性。利用文献计量学方法对近年来的相关文献进行分析发现,黄芩苷在动物肠道保护中的研究关注度日益增高。为了更全面地梳理当前黄芩苷在动物肠道保护方面的研究现状,作者对黄芩苷抗动物肠道致病微生物以及维持肠道屏障功能稳态的作用进行了综述,旨在为黄芩苷的进一步深入研究及其在兽医临床中的应用提供参考。

关键词: 黄芩苷; 文献计量学; 药理作用; 肠道保护; 分子机制

Abstract: Baicalin is a kind of flavonoid active substance extracted from the root of Scutellaria baicalensis.Under alkaline environment, the chemical properties of baicalin are unstable, and the glycoside bond in its molecular structure is easily hydrolyzed and the o-diphenol hydroxyl group is easily oxidized.The presence of sugar groups in the molecular structure of baicalin makes it almost insoluble in water, which limits its clinical application.Baicalin is not easily absorbed in the intestine, but under the action of β-glucuronidase produced by intestinal microbes, its glycosyl is removed and converted into baicalin, which is more easily absorbed by the intestine.The metabolites of baicalein were excreted in bile or urine after glucosylation, glucosylation, methylation and hydrolysis in animals.Pharmacological studies have found that it has anti-inflammatory, antibacterial, antiviral, anti-tumor and anti-intestinal damage pharmacological activities.Based on the bibliometrics analysis of the relevant literature in recent years, it is found that the research attention of baicalin in animal intestinal protection is increasing.In order to more comprehensively review the current research status of baicalin in animal intestinal protection, the author reviewed the effects of baicalin on animal intestinal pathogenic microorganisms and maintenance of intestinal barrier function homeostasis, aiming to provide a reference for further research of baicalin and its clinical application in veterinary medicine.

Key words: baicalin; bibliometrics; pharmacologic action; intestinal protection; molecular mechanism

中图分类号:

S853.74

何政科, 苏利娟, 谭晓燕, 李章勋, 曹立亭, 马跃, 杜红旭. 黄芩苷对动物肠道保护作用的研究进展[J]. 中国畜牧兽医, 2024, 51(2): 875-882.

HE Zhengke, SU Lijuan, TAN Xiaoyan, LI Zhangxun, CAO Liting, MA Yue, DU Hongxu. Research Progress on the Protective Effect of Baicalin on Intestinal of Animals[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(2): 875-882.

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