菟丝子总黄酮对生殖内分泌调节的研究进展

doi:10.16431/j.cnki.1671-7236.2021.06.013

摘要/Abstract

摘要： 近年来，菟丝子在临床上经常用于治疗生殖内分泌类疾病，且作用效果显著。菟丝子是旋花科植物，具有毒副作用小、无耐药性、富含多种营养物质、成本低廉等优点，是纯天然的药用植物。菟丝子总黄酮是菟丝子中最有效的成分，具有止泻、滋补肝肾、益精壮阳和安胎等功效，不仅对雌雄动物生殖内分泌活动有调节作用，还对免疫、心脑血管等多个系统具有药理作用。动物的生殖内分泌活动主要由下丘脑-垂体-性腺轴调控，包括生殖激素的分泌以及精子的发生、卵泡的发育，对动物生殖繁育起着重要作用。绝大多数动物的生殖内分泌疾病都与下丘脑-垂体-性腺轴所调节的生殖激素以及生殖器官的发育状态有关，生殖激素可以通过直接或间接作用引起下丘脑-垂体-性腺轴功能性障碍疾病。鉴于目前经济动物禁用激素类药物，因此迫切需要研究安全有效低毒的中草药的作用及其机理，为其广泛应用奠定基础。文章介绍了菟丝子总黄酮主要的药理作用，并详细阐述了菟丝子总黄酮对下丘脑-垂体-性腺轴不同级内分泌活动的调控作用，为今后进一步研究菟丝子总黄酮对下丘脑-垂体-性腺轴调控的作用靶点和作用机理提供参考。

关键词: 菟丝子总黄酮; 下丘脑-垂体-性腺轴; 生殖内分泌; 药理作用

Abstract: In recent years,the Semen Cuscutae was often used in the treatment of reproductive endocrine diseases in clinic,and the effect is remarkable.Semen Cuscutae is a kind of convolvulaceae plant,which has the advantages of small side effects,no drug resistance,rich in a variety of nutrients,low cost and so on.It is a pure natural medicinal plant.The total flavonoids of Semen Cuscutae is the most effective component in Semen Cuscutae,which has the functions of preventing diarrhea,nourishing liver and kidney,improve sperm quality,enhance male function and pacifying fetus,etc.It is not only regulates reproductive endocrine activities of male and female animals,but also has pharmacological effects on immune,cardiovascular and cerebrovascular systems.Reproductive endocrine activities in animals are mainly regulated by the hypothalamus-pituitary-gonadal axis,including the secretion of reproductive hormones,spermatogenesis and follicular development,which play an important role in animal reproduction.Most of the animal reproductive endocrine diseases are linked to the hypothalamus-pituitary gonadal axis adjustment by the developmental state of the reproductive hormones and reproductive organs,reproductive hormones can cause hypothalamus-pituitary-gonadal axis functional disorders by direct effect and indirect effect.Given that hormonal drugs are currently prohibited in economic animals,there is an urgent need to study the effects and mechanisms of safe,effective and low-toxic chinese herbal medicines to lay the foundation for their wide application.In this paper,the main pharmacological effects of total flavonoids of Semen Cuscutae were described,and the regulatory effects of total flavonoids of Semen Cuscutae on different levels of endocrine activity of hypothalamus-pituitary-gonad axis were described in detail.The purpose of this study is to provide theoretical reference for further study on the target and mechanism of total flavonoids of Semen Cuscutae on the regulation of hypothalamus-pituitary-gonad axis.

Key words: total flavonoids of Semen Cuscutae; hypothalamic-pituitary-gonadal axis; reproductive endocrine; pharmacological action

中图分类号:

S829.9

赵千惠, 薛文慧, 郭禹, 张双, 李永, 李晨瑶, 霍书英. 菟丝子总黄酮对生殖内分泌调节的研究进展[J]. 中国畜牧兽医, 2021, 48(6): 2002-2010.

ZHAO Qianhui, XUE Wenhui, GUO Yu, ZHANG Shuang, LI Yong, LI Chenyao, HUO Shuying. Research Progress on the Regulation of Reproductive Endocrine by Total Flavonoids of Semen Cuscutae[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(6): 2002-2010.

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