利福昔明的药理作用及其在奶牛疾病防治中应用的研究进展

doi:10.16431/j.cnki.1671-7236.2015.12.036

摘要/Abstract

摘要： 利福昔明是一种治疗奶牛疾病的新药,抗菌谱广,抗菌活性强,抗菌机制独特,无致突变、致畸、致癌及生殖毒性等,适合作为局部用药。作者综述了利福昔明的研究现状,并对其理化性质、作用机制、药动学、药理毒理学性质及在临床疾病防治中的应用进行了描述,为利福昔明在动物临床疾病防治应用方面提供理论依据,以便兽医工作者全面了解该药,进而指导其临床应用。

关键词: 利福昔明; 药理作用; 奶牛疾病; 临床应用

Abstract: Rifaximin is a kind of new drug for the treatment of dairy cow disease which antimicrobial spectrum is wide.It has a strong antibacterial activity and unique antibacterial mechanism.Rifaximin is suit for local administration because it is no mutagenic,abnormal toxicity,carcinogenicity and reproduction toxicity and so on.In this paper,the physical and chemical properties,action mechanism,pharmacokinetic,pharmacology and toxicology properties,clinical application were investigated and reviewed,so as to provide a theoretical basis for the application in prevention and treatment of animal diseases,and make veterinary workers have a comprehensive understanding of rifaximin and guide the clinical application.

Key words: rifaximin; pharmacological action; dairy cow disease; clinical application

中图分类号:

黄慧丽, 徐飞, 刘义明, 李秀波. 利福昔明的药理作用及其在奶牛疾病防治中应用的研究进展[J]. , 2015, 42(12): 3358-3363.

HUANG Hui-li, XU Fei, LIU Yi-ming, LI Xiu-bo. Research Progress on Pharmacological Action of Rifaximin and its Application in Prevention and Treatment of Dairy Cow Disease[J]. , 2015, 42(12): 3358-3363.

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