生长激素激活受体机理的研究进展

›› 2013, Vol. 40 ›› Issue (10): 148-151.

生长激素激活受体机理的研究进展

杨艳红, 付志玲, 兰海楠, 李维, 刘禹, 郭风, 张辉, 崔焕忠, 赵雪, 郑鑫

吉林农业大学动物科技学院, 吉林长春 130118

收稿日期:2013-02-02 出版日期:2013-10-20 发布日期:2013-12-19
通讯作者: 郑鑫
作者简介:杨艳红(1988-)女,内蒙古人,硕士生,研究方向:动物遗传育种与繁殖。
基金资助:
国家自然科学基金(30871842);吉林省教育厅十二五技术研究项目(201239)。

Research Progress on the Mechanism of Growth Hormone-activated Receptor

YANG Yan-hong, FU Zhi-ling, LAN Hai-nan, LI Wei, LIU Yu, GUO Feng, ZHANG Hui, CUI Huan-zhong, ZHAO Xue, ZHENG Xin

College of Animal Science, Jilin Agricultural University, Changchun 130118, China

Received:2013-02-02 Online:2013-10-20 Published:2013-12-19

摘要/Abstract

摘要： 生长激素(growth hormone,GH)是一种含有191个氨基酸的多肽类激素,分子质量为22 ku,由垂体前叶分泌进入血液循环,与靶细胞膜表面以二聚体形式存在的生长激素受体(growth hormone receptor,GHR)相结合。对于受体的激活来说,仅是二聚化还不够,还需在GH的诱导下发生构象变化,进而才能诱发Janus激酶2(Janus kinase 2,JAK2)的酪氨酸磷酸化,并通过4条不同的路径将信号传入细胞内,从而发挥代谢、增殖及分化等一系列生理效应。作者就生长激素与受体的结构、作用机理、信号转导通路的进展进行综述。

关键词: 生长激素; 生长激素受体; 作用机理; 信号转导

Abstract: The growth hormone (GH),a 191 amino acid polypeptide secreted by the anterior pituitary into the blood circulation,has a molecular weight of 22 ku. It binds to membrane receptors existing as a preformed dimer in target tissues to cause a conformational change to exert on its effects. Janus kinase 2 (JAK2) and other cytokines are rapidly activated after GH binding and induced four different signal transduction pathways which bring signal into cells to generate a series of physiological effects such as metabolism,proliferation and differentiation. This article reviewed the structure,mechanism of action,and signal transduction pathways of growth hormone and growth hormone receptor.

Key words: growth hormone; growth hormone receptor; mechanism of action; signal transduction

中图分类号:

Q257

杨艳红, 付志玲, 兰海楠, 李维, 刘禹, 郭风, 张辉, 崔焕忠, 赵雪, 郑鑫. 生长激素激活受体机理的研究进展[J]. , 2013, 40(10): 148-151.

YANG Yan-hong, FU Zhi-ling, LAN Hai-nan, LI Wei, LIU Yu, GUO Feng, ZHANG Hui, CUI Huan-zhong, ZHAO Xue, ZHENG Xin. Research Progress on the Mechanism of Growth Hormone-activated Receptor[J]. , 2013, 40(10): 148-151.

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