猪繁殖与呼吸综合征病毒细胞受体研究进展

摘要/Abstract

摘要： 猪繁殖与呼吸综合征病毒(porcine reproductive and respiratory syndrome virus,PRRSV)主要是通过与宿主细胞表面的特异性受体结合,利用细胞的内吞作用而感染易感细胞。作者对猪繁殖与呼吸综合征病毒相关受体的研究进行了综述,迄今已报道了5种独立的但功能相关的受体:硫酸乙酰肝素、唾液酸黏附素、波形蛋白、CD163和非肌肉肌动蛋白ⅡA。对受体的功能特性进行研究,将为PRRSV的感染机理和病毒性疾病的预防和治疗具有重要的意义。

关键词: 猪繁殖与呼吸综合征病毒; 受体; 硫酸乙酰肝素; 唾液酸黏附素; 波形蛋白; CD163; 非肌肉肌动蛋白ⅡA

Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) enters the host cells via a mechanism of receptor-mediated endocytosis. The entry mechanism is mediated by attachment to one or more cellular receptors and/or coreceptor on the cell surface and internalization. This article mainly describes several receptors for PRRSV. As far, it is reported five receptors of PRRSV which are independent and associated, heparin sulphate (HS), sialoadhesin (Sn),vimentin, CD163 and non-muscle myosinⅡA. It plays a significant role for the mechanism of PRRSV infection or disease prevention and treatment by studying the function of cellular receptors of PRRSV.

Key words: porcine reproductive and respiratory syndrome virus; receptor; sialoadhesin; heparin sulfate; vimentin; CD163; non-muscle myosinⅡA

中图分类号:

S852.2

李红, 周恩民, 易建中. 猪繁殖与呼吸综合征病毒细胞受体研究进展[J]. , 2013, (7): 77-81.

LI Hong, ZHOU En-min, YI Jian-zhong. Research Progress on Cellular Receptors of Porcine Reproductive and Respiratory Syndrome Virus[J]. , 2013, (7): 77-81.

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