中国畜牧兽医 ›› 2023, Vol. 50 ›› Issue (9): 3652-3662.doi: 10.16431/j.cnki.1671-7236.2023.09.021
李璐1,2,3, 谷振慧4, 冯涛2,3, 王红娜1
收稿日期:
2023-01-10
出版日期:
2023-09-05
发布日期:
2023-08-24
通讯作者:
冯涛, 王红娜
E-mail:fengtao_gs@163.com;wanghongna08@163.com
作者简介:
李璐,E-mail:lilu990445@163.com。
基金资助:
LI Lu1,2,3, GU Zhenhui4, FENG Tao2,3, WANG Hongna1
Received:
2023-01-10
Online:
2023-09-05
Published:
2023-08-24
摘要: 子宫内膜增生是雌性动物正常子宫状态的一种,但子宫内膜过度增生能引起不同程度的功能性子宫出血、胚胎着床失败以及绝经后阴道出血等,对繁殖产生消极影响,并且有发展成为子宫内膜癌的风险。类固醇激素,包括雌激素、孕激素和雄激素等,在子宫内膜增生中发挥重要作用。高浓度雌激素或长期低浓度雌激素刺激,且无孕激素抵抗,是造成子宫内膜过度增生的主要原因,雄激素与孕激素类似,有对抗雌激素的作用。子宫内膜过度增生现象也常发生于猪定时输精过程中,常用的生殖激素孕马血清促性腺激素在显著提高动物排卵数的同时通过促进卵巢雌二醇的分泌造成子宫内膜过度增生,对胚胎着床造成负面影响。目前类固醇激素在子宫内膜增生中的作用机制尚不完全清楚,作者分别介绍了子宫内膜增生的类型,简述了不同动物子宫内膜增生的研究进展,分析了类固醇激素在子宫内膜增生中的作用与可能的机理,阐述了其他因子和基因对子宫内膜增生的影响及子宫内膜增生的防治,以期为动物子宫内膜过度增生的防治提供理论参考。
中图分类号:
李璐, 谷振慧, 冯涛, 王红娜. 类固醇激素在子宫内膜过度增生中的作用机理[J]. 中国畜牧兽医, 2023, 50(9): 3652-3662.
LI Lu, GU Zhenhui, FENG Tao, WANG Hongna. Role and Mechanism of Steroid Hormones in Endometrial Hyperplasia[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(9): 3652-3662.
[1] BINMAHFOUZ L S,EID B G,BAGHER A M,et al.Piceatannol SNEDDS attenuates estradiol-induced endometrial hyperplasia in rats by modulation of NF-κB and Nrf2/HO-1 axes[J].Nutrients,2022,14(9):1891. [2] SINGH G,PUCKETT Y.Endometrial Hyperplasia[M].Treasure island (FL):StatPearls Publishing,2022. [3] NAND S L,WEBSTER M A,BABER R,et al.Bleeding pattern and endometrial changes during continuous combined hormone replacement therapy.The ogen/provera study group[J].Obstetrics and Gynecology,1998,91:678-684. [4] 王海丽.子宫内膜癌中雄激素受体及雄激素代谢酶的表达和临床意义[D].南京:东南大学,2018. WANG H L.The expressions and clinical significance of androgen receptor and androgen metabolism-related enzymes in endometrial carcinoma[D].Nanjing:Southeast University,2018.(in Chinese) [5] 李俊杰,王栋,刘彦,等.母猪批次化生产研发进展[J].猪业科学,2021,38(5):48-52. LI J J,WANG D,LIU Y,et al.Research progress on sow batch production system[J].Swine Industry Science,2021,38(5):48-52.(in Chinese) [6] 邢艳,何玥,吴玉梅.子宫内膜非典型增生及早期子宫内膜癌保留生育功能治疗后妊娠结局相关影响因素的研究进展[J].中国医药导报,2022,19(7):39-42. XING Y,HE Y,WU Y M.Research progress on factors related to pregnancy outcome after fertility preservation therapy for endometrial atypical hyperplasia and early endometrial cancer[J].China Medical Herald,2022,19(7):39-42.(in Chinese) [7] JUNG W,YOO I,HAN J,et al.Expression of caspases in the pig endometrium throughout the estrous cycle and at the maternal-conceptus interface during pregnancy and regulation by steroid hormones and cytokines[J].Frontiers in Veterinary Science,2021,8:641916. [8] DE ZIEGLER D,FANCHIN R,DE MOUSTIER B,et al.The hormonal control of endometrial receptivity:Estrogen (E2) and progesterone[J].Journal of Reproductive Immunology,1998,39(1-2):149-166. [9] KIM S M,KIM J S.A review of mechanisms of implantation[J].Development & Reproduction,2017,21(4):351-359. [10] YOO I,JUNG W,LEE S,et al.Inhibitors of apoptosis:Expression and regulation in the endometrium during the estrous cycle and at the maternal-conceptus interface during pregnancy in pigs[J].Animal Bioscience,2022,35(4):533-543. [11] 全国卫生产业企业管理协会妇幼健康产业分会生殖内分泌学组.中国子宫内膜增生诊疗共识[J].生殖医学杂志,2017,26(10):957-960. REPRODUCTIVE ENDOCRINOLOGY GROUP,CHINESE MATERNAL & CHILD HEALTH INDUSTRY ASSOCIATION,NATIONAL ASSOCIATION OF HEALTH INDUSTRY & ENTERPRISE MANAGEMENT.Consensus on diagnosis and management of endometrial hyperplasia in China[J].Journal of Reproductive Medicine,2017,26(10):957-960.(in Chinese) [12] 周雪勤,梁海莹,韦素连.子宫内膜增生症的治疗现状及研究进展[J].蛇志,2021,33(2):218-220. ZHOU X J,LIANG H Y,WEI S L.Status and research progress of the treatment of endometrial hyperplasia[J].Journal of Snake,2021,33(2):218-220.(in Chinese) [13] 张燕,吕饶,钟海涛,等.三种子宫内膜增生大鼠模型的建立和评价[J].检验医学与临床,2021,18(1):26-29. ZHANG Y,LYU R,ZHONG H T,et al.Establishment and evaluation of three kinds of endometrial hyperplasia rat models[J].Laboratory Medicine and Clinic,2021,18(1):26-29.(in Chinese) [14] TRIMBLE C L,KAUDERER J,ZAINO R,et al.Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia:A gynecologic oncology group study[J].Cancer,2006,106(4):812-819. [15] 任芳.子宫内膜增生症保守治疗疗效及分娩结局的相关因素分析[J].实用妇产科杂志,2020,36(11):843-847. REN F.Analysis of factors related to conservative treatment of endometrial hyperplasia and delivery outcome[J].Journal of Practical Obstetrics and Gynecology,2020,36(11):843-847.(in Chinese) [16] GONCHARENKO V M,BENIUK V A,KALENSKA O V,et al.Predictive diagnosis of endometrial hyperplasia and personalized therapeutic strategy in women of fertile age[J].The EPMA Journal,2013,4(1):24. [17] 莫秋荣,赵苑池,杜杨君,等.子宫内膜增生、子宫内膜样腺癌组织中Twist与maspin的表达及相关性分析[J].现代肿瘤医学,2021,29(18):3266-3270. MO Q R,ZHAO Y C,DU Y J,et al.Expression and correlation of Twist and maspin in endometrial hyperplasia and endometrioid adenocarcinoma[J].Modern Oncology,2021,29(18):3266-3270.(in Chinese) [18] 罗鹏飞.不同条件下小鼠子宫内膜雌激素受体及HOXA10基因表达的研究[D].上海:上海交通大学,2013. LUO P F.Study the expression levels of the mouse endometrial estrogen receptor and HOXA10 gene under different conditions[D].Shanghai:Shanghai Jiao Tong University,2013.(in Chinese) [19] 牛群升.镰刀菌毒素对断奶仔猪血液指标、生殖器官发育和雌激素受体表达的影响[D].泰安:山东农业大学,2015. NIU Q S.Effect of fusarium toxins on hematological values,development of reproductive organs,and expression of estrogen receptor genes in post-weaning gilts[D].Tai’an:Shandong Agricultural University,2015.(in Chinese) [20] 吴迪.猪HOXA10基因的表达调控研究及激素诱导型启动子转基因小鼠与猪的制备与鉴定[D].武汉:华中农业大学,2012. WU D.Expression regulation of porcine HOXA10 gene and establishment of transgenic animal model of hormone-inducible promoter[D].Wuhan:Huazhong Agricultural University,2012.(in Chinese) [21] 廖文双,周敏,徐畅,等.玉米赤霉烯酮和雌二醇对断奶仔猪生长性能、养分利用率和卵巢形态的影响[J].动物营养学报,2020,32(3):1127-1135. LIAO W S,ZHOU M,XU C,et al.Effects of zearalenone and estradiol on growth performance,nutrient utilization and ovary morphology of weaned piglets[J].Chinese Journal of Animal Nutrition,2020,32(3):1127-1135.(in Chinese) [22] SAHAR N,MUHARAM R,PRADHITA A D,et al.Expression of E-Cadherin in pig-tailed monkey (Macaca nemestrina) endometrium after controlled ovarian hyperstimulation[J].BioMed Research International,2021,2021:8824614. [23] 杜雪莲.大剂量孕激素对卵巢切除大鼠子宫发育的影响[D].济南:山东大学,2005. DU X L.Effects of high-dose progestogen ondevelopment of ovariectomized rats’uterus[D].Jinan:Shandong University,2005.(in Chinese) [24] LV M,CHEN P,BAI M,et al.Progestin resistance and corresponding management of abnormal endometrial hyperplasia and endometrial carcinoma[J].Cancers (Basel),2022,14(24):6210. [25] GOMPEL A.Progesterone and endometrial cancer[J].Best Practice & Research.Clinical Obstetrics & Gynaecology,2020,69:95-107. [26] YU K,HUANG Z Y,XU X L,et al.Estrogen receptor function:Impact on the human endometrium[J].Frontiers in Endocrinology,2022,13:827724. [27] NEES L K,HEUBLEIN S,STEINMACHER S,et al.Endometrial hyperplasia as a risk factor of endometrial cancer[J].Archives of Gynecology and Obstetrics,2022,306(2):407-421. [28] 刘春玲.姜曲海母猪初情期前卵巢和子宫腺体发育和激素水平的研究[D].扬州:扬州大学,2004. LIU C L.Studies on hormonal levels and development of ovary and uterine gland for Jiangquhai gilts[D].Yangzhou:Yangzhou University,2004.(in Chinese) [29] 王佩琦,苗欣欣,赵福杰.子宫内膜异位症激素治疗新进展[J].现代妇产科进展,2020,29(3):230-232. WANG P Q,MIAO X X,ZHAO F J.New advances in hormone therapy for endometriosis[J].Progress in Obstetrics and Gynecology,2020,29(3):230-232.(in Chinese) [30] SINGH P,BHARTIYA D.Molecular insights into endometrial cancer in mice[J].Stem Cell Reviews and Reports,2022,18(5):1702-1717. [31] GIBSON D A,ESNAL-ZUFIAURRE A,BAJO-SANTOS C,et al.Profiling the expression and function of oestrogen receptor isoform ER46 in human endometrial tissues and uterine natural killer cells[J].Human Reproduction (Oxford,England),2020,35(3):641-651. [32] BUBB M,BEYER A L,DASGUPTA P,et al.Assessment of G protein-coupled oestrogen receptor expression in normal and neoplastic human tissues using a novel rabbit monoclonal antibody[J].International Journal of Molecular Sciences,2022,23(9):5191. [33] 付稳.ER、AR、VEGF、CD34、Bcl-2、Bax在米非司酮(RU486)治疗子宫内膜单纯性增生前后的表达及意义[D].天津:天津医科大学,2007. FU W.The Expression and significance of ER,AR,VEGF,CD34,Bcl-2 and Bax in simple hyperplasia endometrium before and after treatment with mifepristone (RU486)[D]. Tianjin:Tianjin Medical University,2007.(in Chinese) [34] SUN X,CHRISTOW A,MARIONS L,et al.Progesterone receptor isoform B in the human fallopian tube and endometrium following mifepristone[J].Contraception,2003,67(4):319-326. [35] 温萍华,王细文,张蔚,等.子宫内膜异位症发生发展中的HIF-1α及其相关信号通路[J].国际生殖健康/计划生育杂志,2022,41(3):258-264. WEN P H,WANG X W,ZHANG W,et al.HIF-1α and related pathways in the pathogenesis of endometriosis[J].Journal of International Reproductive Health/Family Planning,2022,41(3):258-264.(in Chinese) [36] HAMILTON K J,ARAO Y,KORACH K S.Estrogen hormone physiology:Reproductive findings from estrogen receptor mutant mice[J].Reproductive Biology,2014,14(1):3-8. [37] ZHANG H,LU S,XU R,et al.Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor[J].Endocrinology,2020161(12):190. [38] 赵英博.1,25-(OH)2D3对牛子宫内膜上皮细胞雌激素信号通路调控的影响[D].郑州:河南农业大学,2021. ZHAO Y B.Effects of 1,25-(OH)2D3 on the regulation of estrogen signaling pathway in bovine endometrial epithelial cells[D].Zhengzhou:Henan Agricultural University,2021.(in Chinese) [39] 韩珊.内脂素/胰岛素对多囊卵巢综合征子宫内膜间质细胞作用的研究[D].天津:天津医科大学,2018. HAN S.The research on the effect of vistatin/insulin in endometrium stromal cells of patients with polycystic ovary syndrome[D].Tianjin:Tianjin Medical University,2018.(in Chinese) [40] LAGANA A S,VITALE S G,SALMERI F M,et al.Unus pro omnibus,omnes pro uno:A novel,evidence-based,unifying theory for the pathogenesis of endometriosis[J].Medical Hypotheses,2017,103:10-20. [41] FARAH O,BIECHELE S,ROSSANT J,et al.Porcupine-dependent Wnt signaling controls stromal proliferation and endometrial gland maintenance through the action of distinct WNTs[J].Developmental Biology,2017,422(1):58-69. [42] VAN DER HORST P H,WANG Y,VAN DER ZEE M,et al.Interaction between sex hormones and WNT/beta-catenin signal transduction in endometrial physiology and disease[J].Molecular and Cellular Endocrinology,2012,358(2):176-184. [43] 刘冉,陶国伟,甄军晖,等.ER、PR在妊娠期子宫肌瘤组织中的表达及意义[J].山东大学学报(医学版),2016,54(5):45-49. LIU R,TAO G W,ZHEN J H,et al.Expression and significance of ER and PR in fibroids and myometrium during pregnancy[J].Journal of Shandong University (Health Sciences),2016,54(5):45-49.(in Chinese) [44] 刘颖.增殖性子宫内膜上皮孕激素受体表达情况[J].医学信息,2017,30(14):36-37. LIU Y.Progesterone receptor expression in proliferative endometrial epithelium[J].Medical Information,2017,30(14):36-37.(in Chinese) [45] SPORRONG T,HELLGREN M,SAMSIOE G,et al.Comparison of four continuously administered progestogen plus oestradiol combinations for climacteric complaints[J].British Journal of Obstetrics and Gynaecology,1988,95(10):1042-1048. [46] 张经伟,张正红,王正朝.黄体类固醇激素受体的结构功能及其生理调节[J].中国细胞生物学学报,2019,41(8):1628-1632. ZHANG J W,ZHANG Z H,WANG Z C.The Structure,functions and physiological regulation of steroid hormone receptors in the corpus luteum[J].Chinese Journal of Cell Biology,2019,41(8):1628-1632.(in Chinese) [47] 宋婷婷.玉米赤霉烯酮诱导断奶仔猪子宫肥大的机制研究[D].泰安:山东农业大学,2020. SONG T T.Mechanism of zearalenone induced uterine hypertrophy in post-weaning piglets[D].Tai’an:Shandong Agricultural University,2020.(in Chinese) [48] 张文尧,许燕雪,张友忠,等.子宫内膜增生及子宫内膜癌的内分泌特征、甾体激素受体及超微结构研究[J].现代妇产科进展,1994,3(4):311-316. ZHANG W Y,XU Y X,ZHANG Y Z,et al.Study on the endocrinologic characteristics,the receptors of steroid hormone and the ultramicroscopic structures for the endometrial hyperplasia and endometrial carcinomas[J].Progress in Obstetrics and Gynecology,1994,3(4):311-316.(in Chinese) [49] JONGEN V H,THIJSSEN J H,HOLLEMA H,et al.Is aromatase cytochrome P450 involved in the pathogenesis of endometrioid endometrial cancer?[J].International Journal of Gynecological Cancer,2005,15(3):529-536. [50] SHAH P D,GUCALP A,TRAINA T A.The role of the androgen receptor in triple-negative breast cancer[J].Womens Health (Lond),2013,9(4):351-360. [51] KHATRI P,HOFFMANN B,SCHULER G.Androgen receptor is widely expressed in bovine placentomes and up-regulated during differentiation of bovine trophoblast giant cells[J].Placenta,2013,34(5):416-423. [52] DUAN H,XIAO L,HU J,et al.Expression of oestrogen receptor,androgen receptor and progesterone nuclear receptor in sheep uterus during the oestrous cycle[J].Reproduction in Domestic Animals,2019,54(10):1305-1312. [53] BOZDOGAN Ö,ATASOY P,EREKUL S,et al.Apoptosis-related proteins and steroid hormone receptors in normal,hyperplastic,and neoplastic endometrium[J].International Journal of Gynecological Pathology:Official Journal of the International Society of Gynecological Pathologists,2002,21(4):375-382. [54] MAKIEVA S,SAUNDERS P T,NORMAN J E.Androgens in pregnancy:Roles in parturition[J].Human Reproduction Update,2014,20(4):542-559. [55] CLOKE B,CHRISTIAN M.The role of androgens and the androgen receptor in cycling endometrium[J].Molecular and Cellular Endocrinology,2012,358(2):166-175. [56] MERTENS H J,HEINEMAN M J,KOUDSTAAL J,et al.Androgen receptor content in human endometrium[J].European Journal of Obstetrics,Gynecology,and Reproductive Biology,1996,70(1):11-13. [57] SLAYDEN O D,BRENNER R M.Flutamide counteracts the antiproliferative effects of antiprogestins in the primate endometrium[J].The Journal of Clinical Endocrinology and Metabolism,2003,88(2):946-949. [58] OHARA M,YOSHIDA-KOMIYA H,ONO-OKUTSU M,et al.Metformin reduces androgen receptor and upregulates homeobox A10 expression in uterine endometrium in women with polycystic ovary syndrome[J].Reproductive Biology and Endocrinology,2021,19(1):77. [59] SLAYDEN O D,NAYAK N R,BURTON K A,et al.Progesterone antagonists increase androgen receptor expression in the rhesus macaque and human endometrium[J].The Journal of Clinical Endocrinology and Metabolism,2001,86(6):2668-2679. [60] GIBSON D A,SIMITSIDELLIS I,COLLINS F,et al.Androgens,oestrogens and endometrium:A fine balance between perfection and pathology[J].The Journal of Endocrinology,2020,246(3):R75-R93. [61] CUNHA G R,SHANNON J M,VANDERSLICE K D,et al.Autoradiographic analysis of nuclear estrogen binding sites during postnatal development of the genital tract of female mice[J].Journal of Steroid Biochemistry,1982,17(3):281-286. [62] YAMASHITA S,NEWBOLD R R,MCLACHLAN J A,et al.Developmental pattern of estrogen receptor expression in female mouse genital tracts[J].Endocrinology,1989,125(6):2888-2896. [63] WEISZ A,BRESCIANI F.Estrogen induces expression of c-fos and c-myc protooncogenes in rat uterus[J].Molecular Endocrinology,1988,2(9):816-824. [64] 杨金福.一例仓鼠子宫内膜局灶性增生的诊断与治疗[J].畜牧兽医杂志,2021,40(4):124-126. YANG J F.Diagnosis and treatment of a case of hamster endometrium focal hyperplasia[J].Journal of Animal Science and Veterinary Medicine,2021,40(4):124-126.(in Chinese) [65] ROSENFELD C S,WAGNER J S,ROBERTS R M,et al.Intraovarian actions of oestrogen[J].Reproduction (Cambridge,England),2001,122(2):215-226. [66] SHOBANA N,KUMAR M K,NAVIN A K,et al.Prenatal exposure to excess chromium attenuates transcription factors regulating expression of androgen and follicle stimulating hormone receptors in Sertoli cells of prepuberal rats[J].Chemico-Biological Interactions,2020,328:109188. [67] BRENNER R M,WEST N B,MCCLELLAN M C.Estrogen and progestin receptors in the reproductive tract of male and female primates[J].Biology of Reproduction,1990,42(1):11-19. [68] HARMON B G,MUNDAY J S,CRANE M M.Diffuse cystic endometrial hyperplasia and metastatic endometrial adenocarcinoma in a vietnamese pot-bellied pig (Sus scrofa)[J].Journal of Veterinary Diagnostic Investigation,2004,16(6):587-589. [69] DVRLINGER S,KNECHT C,GUMPENBERGER M,et al.Cystic endometrial hyperplasia and uterine adenocarcinoma in two miniature pigs[J].Tierarztliche Praxis Ausgabe Grosstiere Nutztiere,2022,5:333-339. [70] GAJ[XCE弯.EPS;%120%120;Z-0.5mm;Y-0.5mm,SQ;P]CKA M,RYBARCZYK L,JAKIMIUK E,et al.The effect of experimental long-term exposure to low-dose zearalenone on uterine histology in sexually immature gilts[J].Experimental and Toxicologic Pathology,2012,64(6):537-542. [71] SCHINDLER D,LEWIS G S,ROSENBERG M,et al.Vulvar electrical impedance in periparturient cows and its relation to plasma progesterone,oestradiol-17β and PGFM[J].Animal Reproduction Science,1990,23(4):283-292. [72] BELSTRA B A,WILLENBURG K L,GOMEZ-LOPEZ D H,et al.Effects of the number of sperm and site of uterine semen deposition on conception rate and the number of embryos in weaned sows receiving a single fixed-time insemination[J].Journal of Animal Science,2020,98(9):skaa260. [73] JIA R,CHEN X,ZHU Z,et al.Improving ovulation in gilts using anti-inhibin serum treatment combined with fixed-time artificial insemination[J].Reproduction in Domestic Animals,2021,56(1):112-119. [74] MORSY M A,ABDELRAHEEM W M,EL-HUSSIENY M,et al.Protective effects of irbesartan,an angiotensin receptor blocker with PPARγ agonistic activity,against estradiol benzoate-induced endometrial hyperplasia and atypia in female rats via modulation of TNFα/Survivin pathway[J].Pharmaceuticals (Basel),2021,14(7):649. [75] CHEN M,LI J,ZHANG B,et al.Uterine insulin sensitivity defects induced embryo implantation loss associated with mitochondrial dysfunction-triggered oxidative stress[J].Oxidative Medicine and Cellular Longevity,2021,2021:6655685. [76] 刘甜,陈晓宇,朱志伟,等.卵泡刺激素剂量依赖性表达基因的筛选[J].浙江大学学报(农业与生命科学版),2018,44(2):162-171. LIU T,CHEN X Y,ZHU Z W,et al.Screening of follicle-stimulating hormone dose-dependent expression genes[J].Journal of Zhejiang University(Agriculture.& Life Sciences.),2018,44(2):162-171.(in Chinese) [77] 王婷婷,宋丹,丁永慧.胰岛素抵抗与子宫内膜癌及子宫内膜不典型增生的相关性研究[J].宁夏医学杂志,2021,43(7):588-590. WANG T T,SONG D,DING Y H.Research on the correlation between insulin resistance and endometrial carcinoma and endometrial atypical hyperplasia[J].Ningxia Medical Journal,2021,43(7):588-590.(in Chinese) [78] GUDELSKA M,DOBRZYN K,KIEZUN M,et al.Chemerin affects P4 and E2 synthesis in the porcine endometrium during early pregnancy[J].International Journal of Molecular Sciences,2022,23(2):945. [79] SMOLINSKA N,KIEZUN M,DOBRZYN K,et al.Expression of chemerin and its receptors in the porcine hypothalamus and plasma chemerin levels during the oestrous cycle and early pregnancy[J].International Journal of Molecular Sciences,2019,20(16):38-87. [80] RYTELEWSKA E,KISIELEWSKA K,KIEZUN M,et al.Expression of chemerin and its receptors in the ovaries of prepubertal and mature gilts[J].Molecular Reproduction and Development,2020,89(7):739-762. [81] GUDELSKA M,DOBRZYN K,KIEZUN M,et al.The expression of chemerin and its receptors (CMKLR1,GPR1,CCRL2) in the porcine uterus during the oestrous cycle and early pregnancy and in trophoblasts and conceptuses[J].Animal,2020,14(10):2116-2128. [82] SPICER L J,STEWART R E.Interactions among basic fibroblast growth factor,epidermal growth factor,insulin,and insulin-like growth factor-Ⅰ (IGF-Ⅰ) on cell numbers and steroidogenesis of bovine thecal cells:Role of IGF-Ⅰ receptors[J].Biology of Reproduction,1996,54(1):255-263. [83] 严德萍.孕激素类药物在妇科内分泌疾病中的临床应用价值研究[J].实用妇科内分泌电子杂志,2019,6(9):93. YAN D P.Study on the clinical application value of pregnancine drugs in gynecological endocrine diseases[J].Electronic Journal of Practical Gynecologic Endocrinology,2019,6(9):93.(in Chinese) [84] 吴林玲,闫颖,李军,等.二甲丸对大鼠增生型子宫内膜中ER、PR及BFGF、VEGF的影响[J].湖南中医杂志,2016,32(7):170-173. WU L L,YAN Y,LI J,et al.Effect of Erjia pills on estrogen receptor,progesterone receptor,basic fibroblast growth factor,and vascular endothelial growth factor in hyperplastic endometrium in rats[J].Hunan Journal of Traditional Chinese Medicine,2016,32(7):170-173.(in Chinese) [85] 谢玉培,勒孚银,谭布珍.肠道菌群与子宫内膜癌关系研究进展[J].中国免疫学杂志,2020,36(22):2815-2818. XIE Y P,LE F Y,TAN B Z,et al.Advancement in relationship between intestinal microflora and endometrial cancer[J].Chinese Journal of Immunology,2020,36(22):2815-2818.(in Chinese) [86] 马杏,黄吾男,刘文文,等.子宫内膜及肠道微生物在子宫内膜癌发病中的作用[J].国际妇产科学杂志,2022,49(4):366-370. MA X,HUANG W N,LIU W W,et al.The role of endometrial and intestinal microbiome in the pathogenesis of endometrial carcinoma[J].Journal of International Obstetrics and Gynecology,2022,49(4):366-370.(in Chinese) |
[1] | 钟玲, 陈吕彦烨, 栾悦, 岳潇雨, 陈群, 王勤. 马多趾性状研究进展[J]. 中国畜牧兽医, 2023, 50(7): 2789-2800. |
[2] | 钟粤韵, 杨舒展, 陈非玥, 陆智儿, 李冰心, 李婉雁, 田允波, 黄运茂, 许丹宁, 曹楠. LPS通过ROS/p38/MAPK信号通路对鹅胚肝细胞凋亡的影响[J]. 中国畜牧兽医, 2023, 50(6): 2224-2232. |
[3] | 徐媛媛, 郑海英, 杨春艳, 邓廷贤, 黄晨茜, 冯超, 陆杏蓉, 段安琴, 莫霞, 马小娅, 尚江华. 抑制BMP/Smad信号通路对水牛卵巢颗粒细胞生长和类固醇激素合成的影响[J]. 中国畜牧兽医, 2023, 50(6): 2354-2362. |
[4] | 梁天, 王明迪, 孙鹏, 朱爱臣, 赵千惠, 霍书英. 黄柏、石菖蒲合剂抗炎作用的网络药理学分析[J]. 中国畜牧兽医, 2023, 50(3): 1195-1206. |
[5] | 张豪, 刘祎轩, 朱慧媛, 张朋威, 雷艳茹, 高超群, 李东华, 康相涛. 鸡皮肤毛囊生长差异基因的生物信息学分析[J]. 中国畜牧兽医, 2022, 49(9): 3273-3282. |
[6] | 范秋雨, 武建文, 李焕荣. 药用槐花抗炎活性的网络药理学分析[J]. 中国畜牧兽医, 2022, 49(9): 3622-3632. |
[7] | 陈世钰, 崔帅, 蒋亚君, 鑫婷, 王洋, 郝玉欣, 黄建新, 郭晓宇, 朱鸿飞, 吴佳俊, 贾红. 非洲猪瘟病毒感染后猪外周血淋巴细胞Toll样受体信号通路的lncRNA-mRNA分析[J]. 中国畜牧兽医, 2022, 49(7): 2677-2687. |
[8] | 昝庚秀, 秦颖超, 朱超, 王修启. JAK/STAT信号通路在肠黏膜再生及调节辅助性T细胞应答中的研究进展[J]. 中国畜牧兽医, 2022, 49(6): 2079-2087. |
[9] | 刘倩, 郭志廷, 张康, 王学智, 张景艳, 李建喜. 黄芪多糖对巨噬细胞天然免疫调节的研究进展[J]. 中国畜牧兽医, 2022, 49(5): 1746-1756. |
[10] | 李奇隆, 陈湘楠, 龙凤, 陈嘉玥, 杨森, 王京, 昝林森, 成功. Snail家族基因功能研究进展[J]. 中国畜牧兽医, 2022, 49(4): 1287-1294. |
[11] | 张玉珠, 于超, 郑慧华, 唐欣悦, 黄荣磊, 谢光洪. 原儿茶酸对LPS诱导的小鼠子宫内膜炎的作用机制研究[J]. 中国畜牧兽医, 2022, 49(4): 1585-1591. |
[12] | 吉文汇, 王玉玲, 何翃闳, 付伟, 兰道亮. 维生素A对牦牛卵母细胞体外成熟及后续胚胎发育能力的影响[J]. 中国畜牧兽医, 2022, 49(12): 4707-4714. |
[13] | 朱家威, 赵潇晗, 马翠, 汤超华, 司玮, 赵青余, 张军民, 秦玉昌. GPX4失活通过JNK通路缓解LPS诱导巨噬细胞炎症反应[J]. 中国畜牧兽医, 2022, 49(11): 4178-4186. |
[14] | 冯志强, 王腾飞, 赵善江, 郝海生, 杜卫华, 赵学明, 邹惠影, 朱化彬, 庞云渭. Nrf2/Keap1-ARE通路的生物学功能及其信号调控[J]. 中国畜牧兽医, 2022, 49(1): 81-90. |
[15] | 孙镘熹, 陈芳, 王志勇, 刘畅, 黄世会, 李升, 牛熙, 王嘉福, 冉雪琴. MAPK信号通路2个结构变异多态性及其与香猪生长性状的关联分析[J]. 中国畜牧兽医, 2021, 48(7): 2448-2456. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||