国内外食品源及动物源弯曲菌流行性及耐药性调查研究进展

摘要/Abstract

摘要： 弯曲菌是重要的食品源性致病微生物,在很多动物中属于正常携带细菌,能通过食物链传递给人类,可引起人类肠炎的暴发流行和食物中毒。在畜牧养殖业大量抗菌药物的使用,造成动物源弯曲菌耐药性日益增加,给人类带来健康风险。发达国家很早就开展了动物源性弯曲菌流行性和耐药性监测工作,很多发展中国家也对弯曲菌流行性和耐药性监测越来越重视,文章将就近年来国内外动物源性弯曲菌的流行及耐药情况调查工作做简单的总结,为中国动物源性弯曲菌流行性和耐药性工作的开展提供比较及理论分析数据。

关键词: 弯曲菌; 流行性; 耐药性

Abstract: Campylobacter is a main bacterial source of human acute gastroenteritis, many animals are natural host of Campylobacter and serves as major reservoirs for this pathogenic organism. As a foodborne pathogen, Campylobacter is transmitted to humans via food chain. Antimicrobial agents have been widely used for growth promotion and disease control. Thus, agricultural use of antibiotics poses a risk for selecting antibiotic resistant pathogens that can be potentially transmitted to humans and may compromise clinical treatment. In this article, prevalence and antimicrobial resistance data of China and abroad was introduced briefly.

Key words: Campylobacter; prevalence; resistance

中图分类号:

R378

陈霞, 李娟, 骆鹏杰, 袁敏, 吴永宁. 国内外食品源及动物源弯曲菌流行性及耐药性调查研究进展[J]. 中国畜牧兽医.

CHEN Xia, LI Juan, LUO Peng-jie, YUAN Min, WU Yong-ning. Prevalence and Antimicrobial Resistance Data of Campylobacters Home and Abroad[J]. .

参考文献

1 王振国,罗雁菲,肖成蕊,等.鸡肉中弯曲杆菌属的分离与鉴定[J].吉林农业大学学报,2000,22(2):83~85.

2 乔昕,袁宝君,吴高林.南京市2006年鸡肉产品中空肠弯曲菌污染状况调查[J].江苏预防医学,2007,18(2):37~38.

3 刘自才.鹤鹑、鸡、鸭、牛的胆汁空肠弯曲菌带菌观察[J].中国人兽共患病杂志,1999,15(3):36.

4 朱万孚,庄辉.医学微生物[M].北京:北京大学医学出版社,2007.

5 朱战波,崔玉东,侯喜林,等.奶牛流产胎儿弯曲菌的分离鉴定[J].中国兽医杂志,2004,12(40):28~29.

6 吴斌,秦成,钱斯日古楞.肉及肉制品中空肠弯曲菌的污染情况调查[J].中国微生态学杂志,2004,16(4):212~214.

7 张茂俊,张建中.空肠弯曲菌耐药现状[J].疾病监测,2007,22(12):793~796.

8 张濛,张聪恪,张秀丽,等.MIC法测定空肠弯曲菌对氯霉素、环丙沙星、萘啶酮酸和红霉素的敏感性研究[J].中国卫生检验杂志,2004,25(5):540~542.

9 杨毓环,马群飞,陈伟伟,等.福建省2003－2005年食品中空肠和结肠弯曲菌的监测与分析[J].中国食品卫生杂志,2007,19(1):15~18.

10辛宏业,胡宝珍.弯曲菌属胎儿弯曲菌空肠亚种的鸡群携带率及其与蝇类关系的调查[J].医学动物防治,1986,2:14.

11周佳,刘书亮,侯小刚,等.四川省动物性食品源沙门氏菌的耐药性监测与分析[J].中国畜牧兽医,2011,38(3):188~191.

12侯凤伶,申志新,王英豪,等.保定市空肠弯曲菌感染情况调查分析[J].中国卫生检验杂志,2006,16(6):725~726.

13侯建军,朱建国,华修国,等.猪、鸡间空肠弯曲杆菌感染分布状况的调查研究[J].中国动物检疫,2007,24(6):29~32.

14姚正富,游秀贞,姚国文,等.乌鸡、番鸭空肠弯曲菌带菌观察[J].职业与健康,2005,21(8):1260.

15徐君怡,曹际娟,郑秋月,等.多重PCR-变性高效液相色谱检测食品中空肠弯曲菌和结肠弯曲菌[J].中国预防兽医学报,2009,31(3):207~212.

16袁丹茅,金建潮,刘素意.龙岩市5类食品中空肠和结肠弯曲菌监测[J].预防医学情报杂志,2010,26(3):182~184.

17贾莉.猪空肠弯曲菌和结肠弯曲菌的检测[J].畜牧兽医杂志,1996,4(15):29.

18黄金林,许海燕,张弓,等.江苏奶牛空肠弯曲菌和结肠弯曲菌流行状况及耐药性分析[J].中国人兽共患病学报,2007,23(10):1016~1020.

19黄金林,许海燕,郑国军,等.部分省市鸡群空肠弯曲菌和结肠弯曲菌的流行状况分析[J].中国预防兽医学报,2008,30(1):72~75.

20翟伟华,焦扬,黄金林,等.禽肉中弯曲菌污染现状和防控措施研究进展[J].动物医学进展,2010,31(S):180~184.

21潘玲,李槿年.家鸭胭体空肠弯曲菌及沙门氏菌污染情况调查[J].动物检疫,1992,9(2):48~49.

22薛峰,栾军,张小荣,等.2006－2008年江苏地区不同宿主感染空肠弯曲菌及其耐药性[J].中国人兽共患病学报,2009,25(12):1206~1209.

23Alekrus S F,Tollefson K.Human campylobacteriosis:a challenge for the veterinary profession[J].J Am Vet Med Assoc,2003,223:445~452.

24Alfredson D A,Korolik V.Antibiotic resistance and resistance mechanisms in Campylobacter jejuni and Campylobacter coli[J].FEMS Microbiol Lett,2007,277:123~132.

25Allos B M.Campylobacter jejuni infections:update on emerging issues and trends[J].Clin Infect Dis,2001,32:1201~1206.

26Andersen S R,Saadbye P,Shukri N M,et al.Antimicrobial resistance among Campylobacter jejuni isolated from raw poultry meat at retail level in Denmark[J].Int J Food Microbiol,2006,107:250~255.

27Bennarski M,Wieliczko A.Antimicrobial resistance of thermophilic Campylobacter spp. isolated from cattle in Poland[J].Pol J Vet Sci,2010,13(1):189~191.

28Bester L A,Essack S Y.Prevalence of antibiotic resistance in Campylobacter isolates from commercial poultry suppliers in KwaZulu-Natal,South Africa[J].Antimicrob Chemother,2008,62:1298~1300.

29Biasi R S,Macedo R E F, de Malaquias M A S,et al.Prevalence,strain identification and antimicrobial resistance of Campylobacter spp. isolated from slaughtered pig carcasses in Brazil[J].Food Control,2011,22(5):702~707.

30Chen X,Naren G W,Wu C M,et al.Prevalence and antimicrobial resistance of Campylobacter isolates in broilers from China[J].Vet Microbiol,2010,144(1~2):133~139.

31Chu Y W,Chu M Y,Luey K Y,et al.Genetic relatedness and quinolone resistance of Campylobacter jejuni strains isolated in 2002 in Hong Kong[J].J Clin Microbiol,2004,42(7):3321~3323.

32Deckert A,Valdivieso-Garcia A,Reid-Smith R,et al.Prevalence and antimicrobial resistance in Campylobacter spp. isolated from retail chicken in two health units in Ontario[J].Food Prot,2010,73(7):1317~1324.

33Englen M D,Hill A E,Dargatz D A,et al.Prevalence and antimicrobial resistance of Campylobacter in US dairy cattle[J].J Appl Microbiol,2006,102:1570~1577.

34Ewnetu D,Mihret A.Prevalence and antimicrobial resistance of Campylobacter isolates from humans and chickens in Bahir Dar,Ethiopia[J].Foodborne Pathog Dis,2010,7(6):667~670.

35Gormley F J,Strachan N J,Reay K,et al.Antimicrobial resistance profiles of Campylobacter from humans,retail chicken meat, and cattle feces[J].Foodborne Pathog Dis,2010,7(9):1129~1131.

36Hannon S J,Inglis G D,Allan B,et al.Prevalence and risk factor investigation of Campylobacter species in retail ground beef from Alberta,Canada[J].Food Prot Trends,2009,29(11):780~786.

37Hariharan H,Sharma S,Chikweto A,et al.Antimicrobial drug resistance as determined by the E-test in Campylobacter jejuni,C.coli, and C.lari isolates from the ceca of broiler and layer chickens in Grenada[J].Comp Immun Microbiol Infect Dis,2009,32:21~28.

38Harvey R B,Young C R,Ziprin R L,et al.Prevalence of Campylobacter species isolated from the intestinal tract of pigs raised in an integrated swine production system[J].J Am Vet Med Assoc,1999,214:1601~1604.

39Heuer O E,Pedersen J S,Andersen,et al.Prevalence and antimicrobial susceptibility of thermophilic Campylobacter in organic and conventional broiler flocks[J].Lett Appl Microbiol,2001,33:269~274.

40Hofshagen M,Kruse H.Reduction in flock prevalence of Campylobacter spp. In broilers in Norway after implementation of an action plan[J].J Food Protect,2005,68:2220~2223.

41Humphre T,O’Brien S,Madsen M.Campylobacter as zoonotic pathogens: A food production perspective[J].J Food Microbiol,2007,117:237~257.

42Johnsen G,Kruse H,Hofshagen M.Genotyping of thermotolerant Campylobacter from poultry slaughterhouse by amplified fragment length polymorphism[J].J Appl Microbiol,2007,103:271~279.

43Kim H J,Kim J H,Kim Y I,et al.Prevalence and characterization of Campylobacter spp. isolated from domestic and imported poultry meat in Korea,2004-2008[J].Foodborne Pathog Dis,2010,7(10):1203~1209.

44Kramer J M,Frost J A,Bolton F J,et al.Campylobacter contamination of raw meat and poultry at retail sale: identification of multiple types and comparison with isolates from human infection[J].J Food Protect,2000,63(12):1654~1659.

45Lay K S,Vuthy Y,Song P,et al.Prevalence,numbers and antimicrobial susceptibilities of Salmonella serovars and Campylobacter spp. in retail poultry in Phnom Penh, Cambodia[J].J Vet Med Sci,2011,73(3):325~329.

46Lindmark H,Harbom B,Thebo L,et al.Genetic characterization and antibiotic resistance of Campylobacter jejuni isolated from meats, water, and humans in Sweden[J].J Microbiol,2004,42:700~706.

47Mdegela R H,Laurence K,Jacob P,et al.Occurrences of thermophilic Campylobacter in pigs slaughtered at Morogoro slaughter slabs,Tanzania[J].Trop Anim Health Prod,2011,43:83~87.

48Mevius D,Veldman K,Broman T,et al.Antimicrobial resistance profiles of Campylobacter jejuni isotates from wild birds in Sweden[J].Appl Environ Microbiol,2005,71:2438~2441.

49Moran L,Scates P,Madden R H.Prevalence of Campylobacter spp. in raw retail poultry on sale in Northern Ireland[J].J Food Protect,2009,72(9):1830~1835.

50Nayak R,Stewart T,Nawaz M,et al.In vitro antimicrobial susceptibility genetic diversity and prevalence of UDP-glucose 4-epimerase (galE) gene in Campylobacter coli and Campylobacter jejuni from Turkey production facilities[J].Food Microbiol,2006,23:379~392.

51Newell D G,Fearnley C.Sources of Campylobacter colonization in broiler chickens[J].Appl Environ Microbiol,2003,69:4343~4351.

52Padungton P,Kaneene J B.Campylobacter spp. in human,chickens,pigs and their antimicrobial resistance[J].J Vet Med Sci,2003,65:161~170.

53Parkhill J,Wren B W,Mungall K,et al.The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences[J].Nature,2000,403:665~668.

54Pleydell E J,Rogers L,Kwan E,et al.Low levels of antibacterial drug resistance expressed by Gram-negative bacteria isolated from poultry carcasses in New Zealand[J].N Z Vet J,2010,58(5):229~236.

55Qiuiones B,Parker C T,Janda J M Jr,et al.Detection and genotyping of Arcobacter and Campylobacter isolates from retail chicken samples by use of DNA oligonucleotide arrays[J].Appl Environ Microbial,2007,73(11):3645~3655.

56Römmer A-C,Engvall E O,Andersson L,et al.Species identification by genotyping and determination of antibiotic resistance in Campylobacter jejuni and Campylobacter coli from humans and chickens in Sweden[J].Int J Food Microbiol,2004,96:173~179.

57Shane S M.Campylobacter infection of commercial poultry[J].Rev Sci Tech,2000,19:376~395.

58Stern N J,Bannov V A,Svetoch E A,et al.Distribution and characterization of Campylobacter spp. from Russian poultry[J].J Food Prot,2004,67:239~245.

59Stern N J,Fedorka-Cray P,Bailey J S,et al.Distribution of Campylobacter spp. In selected US poultry production and processing operations[J].J Food Prot,2001,64:1705~1710.

60Svedhem A,Kaijser B.Isolation of Campylobacter jejuni from domestic animals and pets:probabel origin of human infection[J].J Infect,1981,3:37~40.

61Varela N P,Friendship R,Dewe C.Prevalence of resistance to 11 antimicrobials among Campylobacter coli isolated from pigs on 80 grower-finisher farms in Ontario[J].Cana J Vet Res,2007,71:189~194.

62Wysok B,Wiszniewska-Laszczych A,Uradziński J,et al.Prevalence and antimicrobial resistance of Campylobacter in raw milk in the selected areas of Poland[J].Pol J Vet Sci,2011,14(3):473~477.

63Yuki N.Infectious origins of,and molecular mimicry in,Gullain-Barré and Fisher syndromes[J].Lancet Infect Dis,2001,1:29~37.

64Zhao S,Young S R,Tong E,et al.Antimicrobial resistance of Campylobacter isolates from retail meat in the United States between 2002 and 2007[J].Appl Environ Microbiol,2010,76(24):7949~7956.

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