关键词: 病毒感染; 核转录因子-κB; 信号转导

Abstract: Since we found NF-kappaB,it has been studied widely about its molecular biology characteristics,function mechanism and the relationships with diseases. Recently many studies reveal that the NF-kappaB plays an important role in the process of virus infection and disease. The translocation of NF-kappaB from the cytoplasm to the nucleus can be induced when virus infect eukaryotic cells,consequently or inducing transcription of some inflammatory gene to produce a lot of inflammatory factors,or blocking apoptosis and prolonging survival of the host cell to gain time for replication and increase viral progeny production,or promoting the expression of oncogene to make cells cancerization,and so on. Once virus infection,body properties will be changed through NF-kappaB signal transduction and diseases will appear soon. Many fators,which has been found at present,such as stress stimulator,LPS,virus,oxygen free radical and so on,are all able to activate the NF-kappaB and then affect the body's metabolism through NF-kappaB signal pathway. In this paper,the interaction between virus infection and NF-kappaB signal transduction is reviewed.

Key words: virus infection; nuclear transcription factor-κB; signal transduction