›› 2011, Vol. 38 ›› Issue (3): 220-223.

• 兽医临床 • 上一篇    下一篇

猪圆环病毒2型复制及其影响因素

王宪文,姚四新,刘兴友,刘丽艳,杭柏林   

  1. (河南科技学院动物科学学院,河南新乡 453003)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-03-20 发布日期:2011-03-20

The Replication of PCV2 and its Influencing Factors

WANG Xian-wen, YAO Si-xin, LIU Xing-you, LIU Li-yan, HANG Bai-lin   

  1. (College of Animal Science, Henan Institute of Science and Technology, Xinxiang 453003, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2011-03-20 Published:2011-03-20

摘要: 猪圆环病毒2型(PCV2)DNA的复制是滚环复制,Rep和Rep′蛋白是PCV复制所必需的蛋白质,核心元件A*TA*TAC为必需的结合位点。复制的影响因素包括病毒内部因素如病毒基因内的CpG寡核苷酸和干扰素反应元件、病毒黏附受体(硫酸乙酰肝素和硫酸软骨素B乙糖胺)和病毒内吞作用(小GTP酶和肌动蛋白);外部因素如DL-硒蛋氨酸和刀豆素A。抑制PCV2复制的措施有猪营养的全面,干扰RNA技术,疫苗的使用等。

关键词: 猪圆环病毒2型; 复制; 影响因素

Abstract: The replication of PCV2 was rolling-circle replication, the replication proteins Rep and Rep′ of porcine circovirus type 2 were essential for viral replication in transfected cells, the key sequence A*TA*TAC was the essential binding site for Rep an Rep′. The influencing factors included interior factors such as CpG motifs and interferon-stimulated response element in viral gene, attachment receptors (heparan sulfate and chondroitin sulfate B glycosaminoglycans), viral internalization (small GTPases and actin); and exterior factors such as dl-selenomethionine and ConA. The strategy for controlling PCV2 included all-around nutrition, RNA interference and useage of accines.

Key words: PCV2; replication; influencing factors

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