›› 2007, Vol. 34 ›› Issue (4): 153-156.

• 奥特奇专栏 • 上一篇    下一篇

糖原组学研究进展——β-葡聚糖的生理学功能

李万坤1,2,闫鸿斌1,才学鹏1, 郭福存2,3   

  1. 1.中国农业科学院兰州兽医研究所,家畜疫病病原生物学国家重点实验室,甘肃省动物寄生虫病重点实验室,兰州 730046; 2.甘肃农业大学动物医学院, 兰州 730060;3.北京奥特奇生物制品有限公司,怀柔 101407
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-04-20 发布日期:2007-04-20

Review on Glycomics Research-Physiological Function of Β-Glucans

Li Wankun1,2,YAN Hongbin1,CAI Xuepeng1,GUO Fucun2,3
  

  1. 1.National Key Lab of Livestock Pathogenic Biology, Key Lab of Gansu Vet Parasitic Diseases, Lanzhou Institute of Vet Medicine CAAS, Lanzhou 730046,China;2.College of Vet Medicine, Gansu Agri University, Lanzhou 730060,China;3.Alltech Biological Product (China) Co, Ltd. Beijing, 101407,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-04-20 Published:2007-04-20

摘要: 糖原组学(glycomics)是继基因组学和蛋白质组学之后生物学研究的另一重要分支。人体中的糖类有至关重要的功能,糖原组学的快速发展让人们更好地了解糖蛋白类、糖基化过程和它们在生命活动中所起的作用。作者对β-葡聚糖的提取和检测方法及其主要生理学功能的研究进展进行了简要阐述。β-葡聚糖具有抗癌、抗肿瘤作用;能抵抗病毒、真菌、细菌等引起的感染,提高抗病力;具有免疫增强和抗辐射作用,是有效的口服免疫刺激剂;有清除自由基和抗氧化作用;作为膳食纤维能促进肠内有害物的排泄,对霉菌毒素等有很好的吸附作用。可降低血清中胆固醇水平,抑制试验性动脉血栓的形成,预防心血管疾病。

关键词: 糖原组学; β-葡聚糖; 鉴定; 生理功能

Abstract: Glycomics is another important branch of biological research after genomics and proteomics. Carbohydrates play important roles and have many different functions in humans. Rapid development of glycomics helps for better understanding glycoprotein, glycosylation procedure and roles that play during the life time and activities. The article describes isolation and identification methods ofβ-glucans and reviews on research progress in terms of important phyological functions of β-glucans. It is demonstrated that β-glucans has anti-tumor and anti-cancer activities; anti-infections (anti-viral, anti-fungi and anti-bacterial activities) and disease resistance enhancement; capability of immuno-enhancement and anti-radiation and thus it can be effective oral immuno-stimulators; cleaning free radicals and anti-oxidation function; promoting excretion of intestinal toxic contents as dietary fiber; effective adsorption of mycotoxins in animal diets. In addition, it can reduce serum cholesterol contents, and thus prevention animal artery thrombus formation and cardiovascular diseases. 

Key words: glycomics; β-glucan; identification; physiological function

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