戊型肝炎病毒跨物种传播和防控技术研究进展

doi:10.16431/j.cnki.1671-7236.2024.06.035

中国畜牧兽医 ›› 2024, Vol. 51 ›› Issue (6): 2605-2620.doi: 10.16431/j.cnki.1671-7236.2024.06.035

• 预防兽医 • 上一篇

戊型肝炎病毒跨物种传播和防控技术研究进展

何振文^1,2,5, 刘丁语^1,3, 刘宝玲¹, 张翩¹, 王晓虎¹, 王刚¹, 黄元¹, 陈晶¹, 杜宗亮⁴, 蔡汝健¹

1. 广东省农业科学院动物卫生研究所, 广东省畜禽疫病防治研究重点实验室, 农业农村部兽用药物与诊断技术广东科学观测实验站, 广州 510640;
2. 仲恺农业工程学院动物科技学院, 广州 510225;
3. 华中农业大学动物医学院, 生猪健康养殖协同创新中心, 武汉 430000;
4. 清远市龙发种猪有限公司, 英德 511500;
5. 东莞市中堂镇农业技术服务中心, 东莞 523220

收稿日期:2023-12-01 发布日期:2024-06-01
通讯作者: 杜宗亮, 蔡汝健 E-mail:duzongliang@gdaas.cn;466866569@qq.com
作者简介:何振文,E-mail:331424732@qq.com。
基金资助:
广东省省级科技计划项目(2023B0202010014);2021年英德市科技计划项目;云浮市云安区生猪产业园科技支撑与技术示范(动卫经合(2022)K06-005号);生猪智能化动物疫病防疫与诊疗系统(动卫经合(2022)K11-006号)

Research Progress on Cross-species Transmission and Prevention and Control Techniques of Hepatitis E Virus

HE Zhenwen^1,2,5, LIU Dingyu^1,3, LIU Baoling¹, ZHANG Pian¹, WANG Xiaohu¹, WANG Gang¹, HUANG Yuan¹, CHEN Jing¹, DU Zongliang⁴, CAI Rujian¹

1. Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province of Ministry of Agriculture and Rural Affairs, Key Laboratory of Livestock Disease Prevention of Guangdong Province, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China;
2. College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China;
3. The Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430000, China;
4. Qingyuang Longfa Pig Breeding Co., Ltd., Yingde 511500, China;
5. Dongguan Zhongtang Town Agricultural Technical Service Center, Dongguan 523220, China

Received:2023-12-01 Published:2024-06-01

摘要/Abstract

摘要： 戊型肝炎病毒(Hepatitis E virus,HEV)是一种主要通过粪-口途径传播的人兽共患病病原,被认为是引起人类急性肝炎的主要原因之一。HEV可被分为8种基因型,各基因型的分布与地域和工业化水平有关,其中HEV-3与HEV-4具有人兽共患的传播能力,能造成人类和各种动物宿主的感染。除人类外,猪是HEV最常见的宿主,随着研究的深入,发现HEV的宿主呈现多样性,包括牛、羊、鹿、兔和骆驼等多种动物,且各动物宿主之间存在跨物种传播的可能。HEV的跨物种传播是在人类和动物宿主频繁交流的过程中,通过适应性进化而形成的,受到宿主细胞受体和细胞因子的特异性差异限制。HEV基因重组有利于适应宿主的新毒株出现,也可能促进新的传播途径,从而促进HEV跨物种传播。通过对HEV传播途径的研究发现,基因型不同,传播途径也有所差异,而食用携带HEV的动物产品,特别是未煮熟的动物产品是造成人类感染HEV-3和HEV-4的主要原因。此外,水源的污染、职业暴露、输血与器官移植同样是HEV的重要传播途径。针对各种潜在的传播途径,可采取相关的防控手段对HEV进行预防,包括对动物食品进行充分的加热以灭活HEV、对水源进行消毒和净化、做好职业防护和疫苗注射等。为更好地了解和掌握HEV的流行规律,各地应加强对HEV的监测,并制定相关的防控策略。笔者从HEV病原学、跨物种感染和防控技术等方面进行综述,以期促进人们对HEV跨物种传播的深入认识并为HEV的防控提供参考。

关键词: 戊型肝炎病毒(HEV); 人兽共患病; 跨物种传播; 防控技术

Abstract: Hepatitis E virus (HEV) is a zoonotic pathogen mainly transmitted by fecal-oral route and is considered to be one of the major causes of acute hepatitis in humans.HEV can be divided into 8 genotypes,and the distribution of each genotype is related to the region and level of industrialization,among which HEV-3 and HEV-4 have zoonotic transmission capacity and can cause infection in human and various animal hosts.Besides human,pig is the most common host of HEV.With the deepening of research,it is found that HEV hosts are diverse,including cattle,sheep,deer,rabbit,camel and other animals,and there is a possibility of cross-species transmission among animal hosts.The cross-species transmission of HEV is formed through adaptive evolution in the process of frequent exchanges between human and animal hosts,constrained by the specificity differences of host cell receptors and cytokines.HEV genetic recombination facilitates the emergence of new strains adapted to hosts and may also promote new transmission pathways,thereby facilitating the cross-species transmission of HEV.The study of HEV transmission routes shows that transmission routes vary according to genotype,and consumption of animal products carrying HEV,especially undercooked animal products,is the main cause of human infection with HEV-3 and HEV-4.In addition,water contamination,occupational exposure,blood transfusion and organ transplantation are also important transmission routes of HEV.According to various potential transmission routes,HEV can be prevented by relevant prevention and control measures,including adequate heating of animal food to inactivate HEV,disinfection and purification of water sources,occupational protection and vaccination.In order to better understand and grasp the epidemic law of HEV,local monitoring of HEV should be strengthened and relevant prevention and control strategies should be formulated.This paper reviewed HEV etiology,cross-species infection and prevention and control technology,in order to promote the in-depth understanding of HEV cross-species transmission and provide reference for HEV prevention and control.

Key words: Hepatitis E virus (HEV); zoonosis; cross-species transmission; prevention and control technology

中图分类号:

S852.65

何振文, 刘丁语, 刘宝玲, 张翩, 王晓虎, 王刚, 黄元, 陈晶, 杜宗亮, 蔡汝健. 戊型肝炎病毒跨物种传播和防控技术研究进展[J]. 中国畜牧兽医, 2024, 51(6): 2605-2620.

HE Zhenwen, LIU Dingyu, LIU Baoling, ZHANG Pian, WANG Xiaohu, WANG Gang, HUANG Yuan, CHEN Jing, DU Zongliang, CAI Rujian. Research Progress on Cross-species Transmission and Prevention and Control Techniques of Hepatitis E Virus[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(6): 2605-2620.

参考文献

[1] WANG B,MENG X J.Hepatitis E virus:Host tropism and zoonotic infection[J].Current Opinion in Microbiology,2021,59:8-15.
[2] ASLAN A T,BALABAN H Y.Hepatitis E virus:Epidemiology,diagnosis,clinical manifestations,and treatment[J]. World Journal of Gastroenterology,2020,26(37):5543-5560.
[3] YUAO D M,MENG X J.Hepatitis E virus:Foodborne,waterborne and zoonotic transmission[J].International Journal of Environmental Research and Public Health,2013,10(10):4507-4533.
[4] CARUSO C,PELETTO S,ROSAMILIA A,et al.Hepatitis E virus:A cross-sectional serological and virological study in pigs and humans at zoonotic risk within a high-density pig farming area[J].Transboundary and Emerging Diseases,2017,64(5):1443-1453.
[5] PURDY M A,DREXLER J F,MENG X J,et al.ICTV virus taxonomy profile:Hepeviridae 2022[J].Journal of General Virology,2022,103(9):10.
[6] RAJI Y E,TOUNG O P,TAIB N M,et al.Hepatitis E virus:An emerging enigmatic and underestimated pathogen[J].Saudi Journal of Biological Sciences,2022,29(1):499-512.
[7] SRIDHAR S,TENG J L L,CHIU T H,et al.Hepatitis E virus genotypes and evolution:Emergence of camel hepatitis E variants[J].International Journal of Molecular Sciences, 2017,18(4):869.
[8] AGGARWAL R.Hepatitis E:Historical,contemporary and future perspectives[J].Journal of Gastroenterology and Hepatology,2011,26(Suppl 1):72-82.
[9] KHUROO M S.Discovery of hepatitis E and its impact on global health:A journey of 44 years about an incredible human-interest story[J].Viruses,2023,15(8):1745.
[10] EL-KAFRAWY S A,HASSAN A M,EL-DALY M M,et al.Seroprevalence of dromedary camel HEV in domestic and imported camels from Saudi Arabia[J].Viruses, 2020,12(5):553.
[11] WANG Y,ZHAO C,QI Y,et al.Hepatitis E virus[J].Advances in Experimental Medicine and Biology,2016:948:1-16.
[12] CANCELA F,NOCETI O,ARBIZA J,et al.Structural aspects of Hepatitis E virus[J].Archives of Virology,2022,167(12):2457-2481.
[13] ROPP S L,TAM A W,BEAMES B,et al.Expression of the Hepatitis E virus ORF1[J].Archives of Virology,2000,145(7):1321-1337.
[14] OJHA N K,LOLE K S.Hepatitis E virus ORF1 encoded nonstructural protein-host protein interaction network[J].Virus Research,2016,213:195-204.
[15] YIN X,YING D,LHOMME S,et al.Origin,antigenicity,and function of a secreted form of ORF2 in Hepatitis E virus infection[J].Proceedings of the National Academy of Sciences of the United States of America,2018,115(18):4773-4778.
[16] SAYED I M,KARAM-ALLAH RAMADAN H,HAFEZ M H R,et al.Hepatitis E virus (HEV) open reading frame 2:Role in pathogenesis and diagnosis in HEV infections[J].Reviews in Medical Virology,2022,32(6):e2401.
[17] TAKAHASHI M,YAMADA K,HOSHINO Y,et al.Monoclonal antibodies raised against the ORF3 protein of Hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces[J].Archives of Virology,2008,153(9):1703-1713.
[18] NAGASHIMA S,TAKAHASHI M,JIRINTAI,et al.A PSAP motif in the ORF3 protein of Hepatitis E virus is necessary for virion release from infected cells[J]. The Journal of General Virology,2011,92(2):269-278.
[19] SRIVASTAVA M,BHUKYA P L,BARMAN M K,et al.Modulation of cellular autophagy by genotype 1 Hepatitis E virus ORF3 protein[J].The Journal of General Virology,2023,104(2):10.
[20] 焦寒伟,周志雄,李梦娟,等.猪戊型肝炎病毒ORF3蛋白影响HepG2细胞核黄素代谢的lncRNA-mRNA调控网络的鉴定[J].中国畜牧兽医,2021,48(12):4618-4627. JIAO H W,ZHOU Z X,LI M J,et al.Identification of lncRNA-mRNA regulatory network of riboflavin metabolism in HepG2 cells affected by swine Hepatitis E virus ORF3 protein[J].China Animal Husbandry & Veterinary Medicine, 2021,48(12):4618-4627.(in Chinese)
[21] YAMADA K,TAKAHASHI M,HOSHINO Y,et al.ORF3 protein of Hepatitis E virus is essential for virion release from infected cells[J].The Journal of General Virology,2009,90(8):1880-1891.
[22] CHELLI E,SUFFREDINI E,DE SANTIS P,et al.Hepatitis E virus occurrence in pigs slaughtered in Italy[J]. Animals (Basel),2021,11(2):277.
[23] PALOMBIERI A,TSACHEV I,SARCHESE V,et al.A molecular study on Hepatitis E virus (HEV) in pigs in Bulgaria[J].Veterinary Sciences,2021,8(11):267.
[24] PELLERIN M,TRABUCCO B,CAPAI L,et al.Low prevalence of Hepatitis E virus in the liver of Corsican pigs slaughtered after 12 months despite high antibody seroprevalence[J].Transboundary and Emerging Diseases,2022,69(5):e2706-e2718.
[25] SOORYANARAIN H,HEFFRON C L,HILL D E,et al.Hepatitis E virus in pigs from slaughterhouses,United States,2017-2019[J].Emerging Infectious Diseases,2020,26(2):354-357.
[26] BATMAGNAI E,BOLDBAATAR B,SODBAYASGALAN A,et al.Hepatitis E virus (HEV) spreads from pigs and sheep in Mongolia[J].Animals (Basel),2023,13(5):891.
[27] 朱泓宇,李雪丽,刘梦超,等.戊型肝炎病毒在我国猪群中的流行及经猪肉传播的风险[J].医学动物防制,2021,37(4):366-369. ZHU H Y,LI X L,LIU M C,et al.Prevalence of Hepatitis E virus in pigs in China and the risks of HEV transmission through pork consumption[J].Journal of Medical Pest Control, 2021,37(4):366-369.(in Chinese)
[28] 张亮权,梁焕斌,王衡,等.猪戊型肝炎病毒的流行病学调查[J].中国畜牧兽医,2012,39(8):215-219. ZHANG L Q,LIANG H B,WANG H,et al.Epidemiological investigation of swine hepatitis E[J].China Animal Husbandry & Veterinary Medicine, 2012,39(8):215-219.(in Chinese)
[29] ZHOU J H,SHANG Y,CAO X A,et al.Potential effects of Hepatitis E virus infection in swine on public health in China[J].Infection,Genetics and Evolution,2019,68:113-118.
[30] LEE H S,DAO D T,BUI V N,et al.Prevalence and phylogenetic analysis of Hepatitis E virus in pigs in Vietnam[J]. BMC Veterinary Research,2020,16(1):333.
[31] CHOI I S,KWON H J,SHIN N R,et al.Identification of swine Hepatitis E virus (HEV) and prevalence of anti-HEV antibodies in swine and human populations in Korea[J].Journal of Clinical Microbiology,2003,41(8):3602-3608.
[32] NISHIZAWA T,TAKAHASHI M,MIZUO H,et al.Characterization of Japanese swine and human Hepatitis E virus isolates of genotype Ⅳ with 99% identity over the entire genome[J].The Journal of General Virology,2003,84(5):1245-1251.
[33] CONLAN J V,JARMAN R G,VONGXAY K,et al.Hepatitis E virus is prevalent in the pig population of Lao people’s democratic republic and evidence exists for homogeneity with Chinese genotype 4 human isolates[J].Infection,Genetics and Evolution,2011,11(6):1306-1311.
[34] 买买提·艾孜子,阿合买提·买买提,翟少华,等.新疆地区屠宰牛肝脏HEV的免疫组织化学检测和流行病学调查[J].黑龙江畜牧兽医,2014,15:157-159. MAIMAITI AIZI,AHEMAITI MAIMAITI,ZHAI S H,et al.Immunohistochemical detection and epidemiological investigation of HEV in the liver of slaughtered cattle in Xinjiang[J].Heilongjiang Animal Science and Veterinary Medicine,2014,15:157-159.(in Chinese)
[35] YAN B,ZHANG L,GONG L,et al.Hepatitis E virus in Yellow cattle,Shandong,Eastern China[J].Emerging Infectious Diseases,2016,22(12):2211-2212.
[36] BASTOS C,EISEN A K A,DEMOLINER M,et al.Hepatitis E virus genotype 3 in bovine livers slaughtered in the state of Rio Grande do Sul,Brazil[J].Brazilian Journal of Microbiology,2022,53(3):1115-1120.
[37] YUGO D M,COSSABOOM C M,HEFFRON C L,et al.Evidence for an unknown agent antigenically related to the Hepatitis E virus in dairy cows in the United States[J].Journal of Medical Virology,2019,91(4):677-686.
[38] BAECHLEIN C,BECHER P.No evidence for zoonotic Hepatitis E virus infection through dairy milk in Germany[J].Hepatology,2017,65(1):394-395.
[39] PALOMBIERI A,ROBETTO S,DI PROFIO F,et al.Surveillance study of Hepatitis E virus (HEV) in domestic and wild ruminants in Northwestern Italy[J].Animals (Basel),2020,10(12):2351.
[40] SARCHESE V,DI PROFIO F,MELEGARI I,et al.Hepatitis E virus in sheep in Italy[J].Transboundary and Emerging Diseases,2019,66(3):1120-1125.
[41] DI MARTINO B,DI PROFIO F,MELEGARI I,et al.Detection of Hepatitis E virus (HEV) in goats[J].Virus Research,2016,225:69-72.
[42] LI S,LIU M,CONG J,et al.Detection and characterization of Hepatitis E virus in goats at slaughterhouse in Tai’an region,China[J].BioMed Research International,2017,2017:3723650.
[43] LONG F,YU W,YANG C,et al.High prevalence of Hepatitis E virus infection in goats[J].Journal of Medical Virology,2017,89(11):1981-1987.
[44] DZIEDZINAKA R,KRZYZANKOVA M,BENA M,et al.Evidence of Hepatitis E virus in goat and sheep milk[J].Viruses,2020,12(12):1429.
[45] KARLSEN A A,KICHATOVA V S,KYUREGYAN K K,et al.Phylodynamic analysis suggests that deer species may be a true reservoir for Hepatitis E virus genotypes 3 and 4[J].Microorganisms,2023,11(2):375.
[46] NEUMANN S,HACKL S S,PIEPENSCHNEIDER M,et al.Serologic and molecular survey of Hepatitis E virus in German deer populations[J].Journal of Wildlife Diseases,2016,52(1):106-113.
[47] DI BARTOLO I,PONTERIO E,ANGELONI G,et al.Presence of Hepatitis E virus in a red deer (Cervus elaphus) population in Central Italy[J].Transboundary and Emerging Diseases,2017,64(1):137-143.
[48] RUTJES S A,LODDER-VERSCHOOR F,LODDER W J,et al.Seroprevalence and molecular detection of Hepatitis E virus in wild boar and red deer in the Netherlands[J].Journal of Virological Methods,2010,168(1-2):197-206.
[49] MENDOZA M V,YONEMITSU K,ISHIJIMA K,et al.Nationwide survey of Hepatitis E virus infection among wildlife in Japan[J].The Journal of Veterinary Medical Science,2022,84(7):992-1000.
[50] SONODA H,ABE M,SUGIMOTO T,et al.Prevalence of Hepatitis E virus (HEV) infection in wild boars and deer and genetic identification of a genotype 3 HEV from a boar in Japan[J].Journal of Clinical Microbiology,2004,42(11):5371-5374.
[51] NAKANE K,ITO H,ISOGAI K,et al.Molecular investigation on the presence of Hepatitis E virus in wild game in Okazaki city,Japan between April 2010 and November 2014[J].Shokuhin Eiseigaku Zasshi,2015,56(6):252-255.
[52] MATSUURA Y,SUZUKI M,YOSHIMATSU K,et al.Prevalence of antibody to Hepatitis E virus among wild sika deer,Cervus nippon,in Japan[J].Archives of Virology,2007,152(7):1375-1381.
[53] TOMIYAMA D,INOUE E,OSAWA Y,et al.Serological evidence of infection with Hepatitis E virus among wild Yezo-deer,Cervus nippon yesoensis,in Hokkaido,Japan[J].Journal of Viral Hepatitis,2009,16(7):524-528.
[54] ZHANG X X,QIN S Y,ZHANG Y,et al.First report of Hepatitis E virus infection in sika deer in China[J]. BioMed Research International,2015,2015:502846.
[55] WANG L,LIU L,WANG L.An overview:Rabbit Hepatitis E virus (HEV) and rabbit providing an animal model for HEV study[J].Reviews in Medical Virology,2018,28:e1961.
[56] COSSABOOM C M,CÓRDOBA L,DRYMAN B A,et al.Hepatitis E virus in rabbits,Virginia,USA[J]. Emerging Infectious Diseases,2011,17(11):2047-2049.
[57] ZHAO C,MA Z,HARRISON T J,et al.A novel genotype of Hepatitis E virus prevalent among farmed rabbits in China[J].Journal of Medical Virology,2009,81(8):1371-1379.
[58] GENG Y,ZHAO C,SONG A,et al.The serological prevalence and genetic diversity of Hepatitis E virus in farmed rabbits in China[J].Infection,Genetics and Evolution,2011,11(2):476-482.
[59] IZOPET J,DUBOIS M,BERTAGNOLI S,et al.Hepatitis E virus strains in rabbits and evidence of a closely related strain in humans,France[J].Emerging Infectious Diseases,2012,18(8):1274-1281.
[60] CHENG X,WANG S,DAI X,et al.Rabbit as a novel animal model for Hepatitis E virus infection and vaccine evaluation[J].PLoS One,2012,7(12):e51616.
[61] WOO P C,LAU S K,TENG J L,et al.New Hepatitis E virus genotype in camels,the Middle East[J].Emerging Infectious Diseases,2014,20(6):1044-1048.
[62] LEE G H,TAN B H,TEO E C,et al.Chronic infection with camelid Hepatitis E virus in a liver transplant recipient who regularly consumes camel meat and milk[J].Gastroenterology,2016,150(2):355-357.
[63] WOO P C,LAU S K,TENG J L,et al.New Hepatitis E virus genotype in Bactrian camels,Xinjiang,China,2013[J].Emerging Infectious Diseases,2016,22(12):2219-2221.
[64] HUANG F F,HAQSHENAS G,SHIVAPRASAD H L,et al.Heterogeneity and seroprevalence of a newly identified avian Hepatitis E virus from chickens in the United States[J].Journal of Clinical Microbiology,2002,40(11):4197-4202.
[65] ZHANG X,BLILC I,TROXLER S,et al.Evidence of genotypes 1 and 3 of avian Hepatitis E virus in wild birds[J].Virus Research,2017,228:75-78.
[66] SITU J,HON-YIN LO K,CAI J P,et al.An immunoassay system to investigate epidemiology of Rocahepevirus ratti (rat Hepatitis E virus) infection in humans[J]. JHEP Reports,2023,5(9):100793.
[67] WANG B,YANG X L.Chirohepevirus from bats:Insights into Hepatitis E virus diversity and evolution[J]. Viruses,2022,14(5):905.
[68] KELLY A G,NETZLER N E,WHITE P A.Ancient recombination events and the origins of Hepatitis E virus[J].BioMed Central Evolutionary Biology,2016,16(1):210.
[69] FORNI D,CAGLIANI R,CLERICI M,et al.Origin and dispersal of Hepatitis E virus[J]. Emerging Microbes and Infections,2018,7(1):11.
[70] BOUQUET J,CHEREL P,PAVIO N.Genetic characterization and codon usage bias of full-length Hepatitis E virus sequences shed new lights on genotypic distribution,host restriction and genome evolution[J].Infection,Genetics and Evolution,2012,12(8):1842-1853.
[71] BAHA S,BEHLOUL N,LIU Z,et al.Comprehensive analysis of genetic and evolutionary features of the Hepatitis E virus[J].BioMed Central Genomics,2019,20(1):790.
[72] WANG X,SUN J,ZHENG Y,et al.Dispersion of synonymous codon usage patterns in Hepatitis E virus genomes derived from various hosts[J].Journal of Basic Microbiology,2022,62(8):975-983.
[73] FEAGINS A R,CÓRDOBA L,SANFORD B J,et al.Intergenotypic chimeric Hepatitis E viruses (HEVs) with the genotype 4 human HEV capsid gene in the backbone of genotype 3 swine HEV are infectious in pigs[J].Virus Research,2011,156(1-2):141-146.
[74] NGUYEN H T,SHUKLA P,TORIAN U,et al.Hepatitis E virus genotype 1 infection of swine kidney cells in vitro is inhibited at multiple levels[J].Journal of Virology,2014,88(2):868-877.
[75] CÓRDOBA L,FEAGINS A R,OPRIESSNIG T,et al.Rescue of a genotype 4 human Hepatitis E virus from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs[J].The Journal of General Virology,2012,93(10):2183-2194.
[76] CHATTERJEE S N,DEVHARE P B,PINGLE S Y,et al.Hepatitis E virus (HEV)-1 harbouring HEV-4 non-structural protein (ORF1) replicates in transfected porcine kidney cells[J].The Journal of General Virology,2016,97(8):1829-1840.
[77] 周建华.戊型肝炎病毒跨物种侵染遗传进化及持续性感染对宿主细胞的影响[D].兰州:甘肃农业大学,2019. ZHOU J H.Genetic features of Hepatitis E virus in cross-species infection and effects of viral persistent infection on host cells[D].Lanzhou:Gansu Agricultural University,2019.(in Chinese)
[78] BENTLEY K,EVANS D J.Mechanisms and consequences of positive-strand RNA virus recombination[J].The Journal of General Virology,2018,99(10):1345-1356.
[79] TAKAHASHI M,NISHIZAWA T,YOSHIKAWA A,et al.Identification of two distinct genotypes of Hepatitis E virus in a Japanese patient with acute hepatitis who had not travelled abroad[J].The Journal of General Virology,2002,83(8):1931-1940.
[80] CHEN X,ZHANG Q,HE C,et al.Recombination and natural selection in Hepatitis E virus genotypes[J].Journal of Medical Virology,2012,84(9):1396-1407.
[81] PÉREZ-LOSADA M,ARENAS M,GALÁN J C,et al.Recombination in viruses:Mechanisms,methods of study,and evolutionary consequences[J].Infection,Genetics and Evolution,2015,30:296-307.
[82] GRIERSON S,HEANEY J,CHENEY T,et al.Prevalence of Hepatitis E virus infection in pigs at the time of slaughter,United Kingdom,2013[J].Emerging Infectious Diseases,2015,21(8):1396-1401.
[83] TREAGUS S,WRIGHT C,BSKER-AUSTIN C,et al.The foodborne transmission of Hepatitis E virus to humans[J].Food and Environmental Virology,2021,13(2):127-145.
[84] CHEN Y J,CAO N X,XIE R H,et al.Epidemiological investigation of a tap water-mediated Hepatitis E virus genotype 4 outbreak in Zhejiang province,China[J].Epidemiology and Infection,2016,144(16):3387-3399.
[85] SMITH D B,PADDY J O,SIMMONDS P.The use of human sewage screening for community surveillance of Hepatitis E virus in the UK[J].Journal of Medical Virology,2016,88(5):915-918.
[86] KASORNDORKBUA C,OPRIESSNIG T,HUANG F F,et al.Infectious swine Hepatitis E virus is present in pig manure storage facilities on United States farms,but evidence of water contamination is lacking[J].Applied and Environmental Microbiology,2005,71(12):7831-7837.
[87] PINA S,BUTI M,COTRINA M,et al.HEV identified in serum from humans with acute hepatitis and in sewage of animal origin in Spain[J].Journal of Hepatology,2000,33(5):826-833.
[88] DOS SANTOS D R,DE PAULA V S,DE OLIVEIRA J M,et al.Hepatitis E virus in swine and effluent samples from slaughterhouses in Brazil[J].Veterinary Microbiology,2011,149(1-2):236-241.
[89] DE SCHRYVER A,DE SCHRIJVER K,FRANÇOIS G,et al.Hepatitis E virus infection:An emerging occupational risk?[J].Occupational Medicine,2015,65(8):667-672.
[90] SHU Y,CHEN Y,ZHOU S,et al.Cross-sectional seroprevalence and genotype of Hepatitis E virus in humans and swine in a high-density pig-farming area in Central China[J].Virologica Sinica,2019,34(4):367-376.
[91] GALLIAN P,PIQUET Y,ASSAL A,et al.Hepatitis E virus:Blood transfusion implications[J].Transfusion Clinique et Biologique,2014,21(4-5):173-177.
[92] XIA N S,ZHANG J,ZHENG Y J,et al.Significance of serological markers and virological marker for hepatitis E in rhesus monkey model[J].Chinese Journal of Hepatology,2004,12(1):13-15.
[93] MATSUBAYASHI K,KANG J H,SAKATA H,et al.A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with Hepatitis E virus via zoonotic food-borne route[J].Transfusion,2008,48(7):1368-1375.
[94] GALLIAN P,POUCHOL E,DJOUDI R,et al.Transfusion-transmitted Hepatitis E virus infection in France[J].Transfusion Medicine Reviews,2019,33(3):146-153.
[95] BOXALL E,HERBORN A,KOCHETHU G,et al.Transfusion-transmitted hepatitis E in a 'nonhyperendemic’ country[J].Transfusion Medicine Reviews,2006,16(2):79-83.
[96] CHEUNG C K M,WONG S H,LAW A W H,et al.Transfusion-transmitted hepatitis E:What we know so far?[J].World Journal of Gastroenterology,2022,28(1):47-75.
[97] AHERFI S,BORENTAIN P,RAISSOUNI F,et al.Liver transplantation for acute liver failure related to autochthonous genotype 3 Hepatitis E virus infection[J].Clinics and Research in Hepatology and Gastroenterology,2014,38(1):24-31.
[98] SRIDHAR S,CHENG V C C,WONG S C,et al.Donor-derived genotype 4 Hepatitis E virus infection,Hong Kong,China,2018[J].Emerging Infectious Diseases,2019,25(3):425-433.
[99] HUANG R,LI D,WEI S,et al.Cell culture of sporadic Hepatitis E virus in China[J].Clinical and Diagnostic Laboratory Immunology,1999,6(5):729-733.
[100] BARNAUD E,ROGÉE S,GARRY P,et al.Thermal inactivation of infectious Hepatitis E virus in experimentally contaminated food[J].Applied and Environmental Microbiology,2012,78(15):5153-5159.
[101] IMAGAWA T,SUGIYAMA R,SHIOTA T,et al.Evaluation of heating conditions for inactivation of Hepatitis E virus genotypes 3 and 4[J].Journal of Food Protection,2018,81(6):947-952.
[102] CUEVAS-FERRANDO E,RANDAZZO W,PÉREZ-CATALUÑA A,et al.HEV occurrence in waste and drinking water treatment plants[J].Frontiers in Microbiology,2020,10:2937.
[103] JIMÉNEZ-RODRÍGUEZ M G,SILVA-LANCE F,PARRA-ARROYO L,et al.Biosensors for the detection of disease outbreaks through wastewater-based epidemiology[J].Trends in Analytical Chemistry,2022,155:116585.
[104] GARCÍA M,FERNÁNDEZ-BARREDO S,PÉREZ-GRACIA M T.Detection of Hepatitis E virus (HEV) through the different stages of pig manure composting plants[J].Microbial Biotechnology,2014,7(1):26-31.
[105] MASCLAUX F G,HOTZ P,FRIEDLI D,et al.High occurrence of Hepatitis E virus in samples from wastewater treatment plants in Switzerland and comparison with other enteric viruses[J].Water Research,2013,47(14):5101-5109.
[106] LI S W,ZHAO Q,WU T,et al.The development of a recombinant hepatitis E vaccine HEV 239[J].Human Vaccines and Immunotherapeutics,2015,11(4):908-914.
[107] ZAMAN K,DUDMAN S,STENE-JOHANSEN K,et al.HEV study protocol:Design of a cluster-randomised,blinded trial to assess the safety,immunogenicity and effectiveness of the hepatitis E vaccine HEV 239 (Hecolin) in women of childbearing age in rural Bangladesh[J].BMJ Open,2020,10(1):e033702.
[108] ROBINSON R A,BURGESS W H,EMERSON S U,et al.Structural characterization of recombinant Hepatitis E virus ORF2 proteins in Baculovirus-infected insect cells[J].Protein Expression and Purification,1998,12(1):75-84.
[109] CAO Y F,TAO H,HU Y M,et al.A phase 1 randomized open-label clinical study to evaluate the safety and tolerability of a novel recombinant hepatitis E vaccine[J].Vaccine,2017,35(37):5073-5080.
[110] KAMILI S,SPELBRING J,CARSON D,et al.Protective efficacy of Hepatitis E virus DNA vaccine administered by gene gun in the cynomolgus macaque model of infection[J].The Journal of Infectious Diseases,2004,189(2):258-264.
[111] LI T C,SUZAKI Y,AMI Y,et al.Protection of cynomolgus monkeys against HEV infection by oral administration of recombinant Hepatitis E virus-like particles[J].Vaccine,2004,22(3-4):370-377.
[112] XIANG K,KUSOV Y,YING G,et al.A recombinant HAV expressing a neutralization epitope of HEV induces immune response against HAV and HEV in mice[J].Viruses,2017,9(9):260.

戊型肝炎病毒跨物种传播和防控技术研究进展

Research Progress on Cross-species Transmission and Prevention and Control Techniques of Hepatitis E Virus

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