奶牛体内超数排卵反应性状研究进展

doi:10.16431/j.cnki.1671-7236.2023.11.019

中国畜牧兽医 ›› 2023, Vol. 50 ›› Issue (11): 4504-4512.doi: 10.16431/j.cnki.1671-7236.2023.11.019

奶牛体内超数排卵反应性状研究进展

黄越川^1,2, 张海亮², 赵善江⁴, 刘展鹏³, 朱化彬⁴, 黄锡霞¹, 王雅春²

1. 新疆农业大学动物科学学院, 乌鲁木齐 830052;
2. 中国农业大学动物科学技术学院, 农业农村部动物遗传育种与繁殖(家畜)重点实验室, 畜禽育种国家工程实验室, 畜禽生物育种全国重点实验室, 北京 100193;
3. 内蒙古国家乳业技术创新中心, 呼和浩特 010020;
4. 中国农业科学院北京畜牧兽医研究所, 农业农村部动物遗传育种与繁殖(家禽)重点实验室, 北京 100193

收稿日期:2023-04-20 出版日期:2023-11-05 发布日期:2023-10-27
通讯作者: 朱化彬, 王雅春 E-mail:zhuhuabin@caas.cn;wangyachun@cau.edu.cn
作者简介:黄越川,E-mail:2532528162@qq.com。
基金资助:
河南省重点研发专项（221111111100）；现代农业（奶牛）产业技术体系建设专项资金（CARS-36）；长江学者和创新团队发展计划（IRT_15R62）；低碳排放与抗热应激奶牛培育关键技术研究及奶羊引种扩繁技术创新（2022-科研攻关-3）

A Review on in vivo Superovulation Response Trait in Dairy Cows

HUANG Yuechuan^1,2, ZHANG Hailiang², ZHAO Shanjiang⁴, LIU Zhanpeng³, ZHU Huabin⁴, HUANG Xixia¹, WANG Yachun²

1. College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China;
2. State Key Laboratory of Farm Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China;
3. National Center of Technology Innovation for Dairy, Hohhot 010020, China;
4. Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received:2023-04-20 Online:2023-11-05 Published:2023-10-27

摘要/Abstract

摘要： 奶牛超数排卵与胚胎移植（multiple ovulation and embryo transfer，MOET）是现代奶牛养殖中的重要生物技术，MOET技术可加快牛群遗传改良速度。然而，不同供体母牛对超数排卵的反应（简称超排反应）存在较大差异，这限制了MOET技术的广泛应用。因此，探究供体母牛超排反应差异的形成原因并预测外源激素处理的效果，进而筛选合适的供体母牛是目前亟待解决的问题。母牛的超排反应受遗传影响，对母牛的超排反应性状进行选育或将大幅提高母牛超数排卵的效率。研究中通常将奶牛的超排反应性状定义为单次超数排卵获得的总胚胎数和可移植胚胎数，这类性状受季节、供体母牛月龄、超排程序及操作人员等非遗传因素的影响，是一类具有中低遗传力的新型繁殖性状，研究发现超排反应性状与多种调控繁殖激素表达及调控细胞生长分化的基因存在显著关联。在遗传育种领域，国内研究人员对奶牛超排反应性状的研究相对较少，目前仅有少量关于超排反应候选基因关联分析的报道。作者从性状定义、非遗传因素建模分析、遗传参数估计和候选基因挖掘鉴定等方面系统综述奶牛超排反应性状的研究进展，并对奶牛超排反应性状的遗传学研究和选育应用进行了展望。

关键词: 奶牛; 超数排卵; 遗传参数; 遗传标记; 候选基因

Abstract: In the modern dairy industry, the multiple ovulation and embryo transfer (MOET) is the key technology, which can significantly accelerate the genetic improvement of dairy population.However, there is a large variation in superovulation response among different donor cows, which is one of the major limitations for the widely applying of superovulation.Therefore, there is an urgent need to explore the causes of variation in superovulation response and to predict the effect of exogenous hormone treatment for donor cows so that suitable donors can be selected.In previous studies, it had been widely reported that the superovulation response trait is heritable in dairy cows, and that genetic selection can substantially improve superovulation efficiency.In general, superovulation response trait is defined as the total number of embryos as well as the number of transferable embryos.Superovulation response trait can be influenced by several factors, including season, donor age, procedure and operator.As a novel reproductive trait with low to medium heritability, it was found to be associated with several genes that regulate the expression of reproductive hormones and cell growth and differentiation.At present, there are relatively few studies on genetics and breeding of superovulation response trait in China, and only a few studies reported candidate genes associated with superovulation response trait.The author systematically reviewed the advance of superovulation response trait in dairy cattle, including the trait definition, modeling of non-genetic factors, estimation of genetic parameters, and identification of candidate genes.In addition, we also discussed the research methods and application of superovulation response trait in the future.

Key words: dairy cow; superovulation; genetic parameter; genetic marker; candidate gene

中图分类号:

S814.4

黄越川, 张海亮, 赵善江, 刘展鹏, 朱化彬, 黄锡霞, 王雅春. 奶牛体内超数排卵反应性状研究进展[J]. 中国畜牧兽医, 2023, 50(11): 4504-4512.

HUANG Yuechuan, ZHANG Hailiang, ZHAO Shanjiang, LIU Zhanpeng, ZHU Huabin, HUANG Xixia, WANG Yachun. A Review on in vivo Superovulation Response Trait in Dairy Cows[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(11): 4504-4512.

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奶牛体内超数排卵反应性状研究进展

A Review on in vivo Superovulation Response Trait in Dairy Cows

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