中国畜牧兽医 ›› 2021, Vol. 48 ›› Issue (12): 4429-4441.doi: 10.16431/j.cnki.1671-7236.2021.12.011
李暄, 佟俊硕, 张大崇, 王丙云, 陈胜锋, 刘璨颖
收稿日期:
2021-07-03
出版日期:
2021-12-20
发布日期:
2021-12-02
通讯作者:
陈胜锋, 刘璨颖
E-mail:liucy3032@163.com
作者简介:
李暄(1996-),女,河北廊坊人,硕士生,研究方向:基础兽医学,E-mail:1391446415@qq.com
基金资助:
LI Xuan, TONG Junshuo, ZHANG Dachong, WANG Bingyun, CHEN Shengfeng, LIU Canying
Received:
2021-07-03
Online:
2021-12-20
Published:
2021-12-02
摘要: 微小核糖核酸(microRNA,miRNA)是一类内源性非编码RNA,具有广泛的基因表达调控作用,可以在转录后水平通过影响靶基因来调控相应蛋白质的表达,进而调节细胞的生命活动。miRNA在哺乳动物卵泡颗粒细胞中表达,并调控颗粒细胞的凋亡。颗粒细胞作为卵巢卵泡中数量最多的细胞群,在卵泡发育过程中起着至关重要的作用,不仅为卵母细胞提供营养物质,还调控其发育和成熟。颗粒细胞凋亡是导致卵泡闭锁的重要原因,影响卵泡的数量和质量从而影响雌性动物的繁殖性能。颗粒细胞凋亡过程受多种因素的调控。文章简述了miRNA对卵巢颗粒细胞凋亡的调控作用及其机制,其中包括miRNA通过调控激素分泌和细胞凋亡相关因子的表达进而调节颗粒细胞的凋亡,miRNA对颗粒细胞凋亡相关信号通路的影响,miRNA调控颗粒细胞凋亡导致的卵巢相关疾病,并总结了对颗粒细胞凋亡有调控作用的miRNA,以及miRNA在疾病诊断和治疗中的潜在作用,以期为后续相关卵巢疾病的发病机制和治疗方案研究,以及提高雌性哺乳动物生殖性能提供指导和参考。
中图分类号:
李暄, 佟俊硕, 张大崇, 王丙云, 陈胜锋, 刘璨颖. miRNA调节卵泡颗粒细胞凋亡及其机制的研究进展[J]. 中国畜牧兽医, 2021, 48(12): 4429-4441.
LI Xuan, TONG Junshuo, ZHANG Dachong, WANG Bingyun, CHEN Shengfeng, LIU Canying. Research Advances on miRNA in Regulating the Apoptosis of Follicular Granulosa Cells and Its Mechanism[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(12): 4429-4441.
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