miRNA调控动物卵泡发育研究进展

doi:10.16431/j.cnki.1671-7236.2021.11.023

中国畜牧兽医 ›› 2021, Vol. 48 ›› Issue (11): 4133-4142.doi: 10.16431/j.cnki.1671-7236.2021.11.023

miRNA调控动物卵泡发育研究进展

冯光杭^1,2, 江声伟², 李耀坤², 柳广斌², 邹娴¹, 刘德武^2,3

1. 广东省农业科学院动物科学研究所, 畜禽育种国家重点实验室, 广东省畜禽育种与营养研究重点实验室, 广州 510640;
2. 华南农业大学动物科学学院, 广州 510642;
3. 岭南现代农业科学与技术广东省实验室, 广州 510642

收稿日期:2021-05-06 出版日期:2021-11-20 发布日期:2021-11-01
通讯作者: 邹娴, 刘德武 E-mail:zouxian08@163.com;dwliu@scau.edu.cn
作者简介:冯光杭(1995-),男,河南信阳人,硕士生,研究方向:动物遗传育种与繁殖,E-mail:fgh@stu.scau.edu.cn
基金资助:
广东省重点领域研发计划（2020B0202090004）；广东省自然科学基金项目（2021A1515010636）；广东省现代农业产业技术体系（2019KJ127、2020KJ128）；国家肉鸡产业技术体系岗位科学家项目（CARS-41）；广东省农科院"十四五"农业优势产业学科团队（202107TD）

Research Advances on Regulation of Animal Follicular Development by miRNA

FENG Guanghang^1,2, JIANG Shengwei², LI Yaokun², LIU Guangbin², ZOU Xian¹, LIU Dewu^2,3

1. State Key Laboratory of Livestock and Poultry Breeding & Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China;
2. College of Animal Science, South China Agricultural University, Guangzhou 510642, China;
3. Lingnan Modern Agricultural Science and Technology Guangdong Laboratory, Guangzhou 510642, China

Received:2021-05-06 Online:2021-11-20 Published:2021-11-01

摘要/Abstract

摘要： 雌性动物的繁殖潜力基于卵泡的发育，该过程受到复杂的基因网络调控。microRNA （miRNA）是一种短的、非编码RNA，在转录后调控基因表达。在过去的十年中，对动物卵泡中非编码RNA的深入研究揭示了miRNA在卵泡发育过程中的关键作用。作者简述了雌性动物卵泡发育过程，总结了miRNA调控卵泡发育的作用机制，包括原始卵泡的激活、生长卵泡的发育选择、卵泡颗粒细胞和卵泡膜细胞的生长调控等，分析了卵泡液外囊泡携带miRNA的功能。但当前卵泡miRNA的研究多集中在细胞敲低模型研究，敲除模型研究较少，因此增加细胞及活体敲除模型的研究有助于更好地了解miRNA在卵泡发育中的功能。本综述可为深入解析雌性动物繁殖性状调控的分子机制提供参考。

关键词: miRNA; 卵巢; 卵泡发育; 颗粒细胞; 膜细胞

Abstract: Fertility of female animals is based on follicular development, which is regulated by complex genetic networks. microRNA (miRNA) is a kind of non-coding RNA that regulates gene expression primarily at the post-transcriptional levels. In the past decade, studies on miRNA in follicles have revealed the key roles of miRNA in follicular development and function. This paper focuses on the follicular development process of female animals, and analyzes the function of miRNA carried by follicular fluid exosomes. The mechanism of miRNA regulating follicular development was summarized, including activation of primordial follicles and selection of growing follicles. The authors also introduced the growth regulation of miRNA on follicular granulosa cells and theca cells. However, most of the current follicular miRNA studies are focused on cellular knockdown model studies, and knockout models are less studied. Therefore, current research should increase the application of cellular and in vivo knockout models, which is helpful to better understand the function of miRNA in follicular development. These results can provide a reference for in-depth analysis of the molecular mechanism of reproductive traits regulation in female animals.

Key words: miRNA; ovary; follicular development; granulosa cell; theca cell

中图分类号:

S814.8

冯光杭, 江声伟, 李耀坤, 柳广斌, 邹娴, 刘德武. miRNA调控动物卵泡发育研究进展[J]. 中国畜牧兽医, 2021, 48(11): 4133-4142.

FENG Guanghang, JIANG Shengwei, LI Yaokun, LIU Guangbin, ZOU Xian, LIU Dewu. Research Advances on Regulation of Animal Follicular Development by miRNA[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(11): 4133-4142.

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miRNA调控动物卵泡发育研究进展

Research Advances on Regulation of Animal Follicular Development by miRNA

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