乳腺康注射液的药效学研究

doi:10.16431/j.cnki.1671-7236.2017.09.039

摘要/Abstract

摘要：

试验旨在研究乳腺康注射液体内外药效。体外药效采用牛津杯法对其进行体外抑菌活性研究；体内药效采用热板法及醋酸致小鼠扭体的镇痛模型、二甲苯及鸡蛋清致炎模型、2，4-二硝基酚及干酵母致大鼠发热6种经典药理模型，对乳腺康注射液进行镇痛、抗炎、解热的药效研究。结果显示，乳腺康注射液对大肠杆菌及金黄色葡萄球菌有较显著的体外抑制作用，中、高剂量能极显著提高小鼠痛阈值，极显著减少醋酸所致扭体次数（P<0.01），中剂量组能显著降低二甲苯致小鼠耳肿胀度及鸡蛋清致小鼠足跖肿胀度（P<0.05），中、高剂量组对2，4-二硝基酚引起的发热在1.5~2.0及3.0~3.5 h有显著的解热作用（P<0.05），对干酵母所引起的大鼠发热在1.0~3.5 h有显著的解热作用（P<0.05）。结果表明，乳腺康注射液能明显抑制大肠杆菌及金黄色葡萄球菌的活性，且具有显著的镇痛抗炎解热作用。

关键词: 乳腺康注射液; 金黄色葡萄球菌; 抗炎; 镇痛; 解热

Abstract:

The study was aimed to investigate the in vitro and in vivo efficacy of Ruxiankang injection.The Oxford cup method was took to study the antibacterial activity in vitro of Ruxiankang injection;Six classical pharmacological models which were hot plate method, acetic acid inducing writhing, xylene inducing ear edema,egg white inducing paw edema, fever in rats induced by 2,4-dinitrophenol and dried yeast were adopted to study the analgesic, anti-inflammatory and antipyretic effects of Ruxiankang injection.The results showed that Ruxiankang injection had significant inhibitory effect in vitro on Escherichia coli and Staphylococcus aureus; And among them, middle and high dose groups could extremely significantly increase the pain threshold of mice and reduce the writhing times of mice (P<0.01);Middle dose group could significantly reduce the degree of ear swelling induced by xylene and foot metatarsus swelling by egg white in mice (P<0.05);Middle and high dose groups had significant antipyretic effect caused by 2, 4-dinitrophenol fever at 1.5 to 2.0 and 3.0 to 3.5 h and dry yeast at 1.0 to 3.5 h (P<0.05).The results indicated that Ruxiankang injection could obviously inhibit Escherichia coli and Staphylococcus aureus activity and had remarkable antipyretic analgesic and anti-inflammatory effects.

Key words: Ruxiankang injection; Staphylococcus aureus; antiinflammatory; analgesia; antipyretic

中图分类号:

R285.5

刘涛, 彭晓凤, 刘翠, 潘春晖, 杨丹, 张文静, 邓燕君, 徐玉玲. 乳腺康注射液的药效学研究[J]. 《中国畜牧兽医》, 2017, 44(9): 2822-2828.

LIU Tao, PENG Xiao-feng, LIU Cui, PAN Chun-hui, YANG Dan, ZHANG Wen-jing, DENG Yan-jun, XU Yu-ling. Study on the Pharmacodynamics of Ruxiankang Injection[J]. , 2017, 44(9): 2822-2828.

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