《中国畜牧兽医》 ›› 2017, Vol. 44 ›› Issue (5): 1462-1467.doi: 10.16431/j.cnki.1671-7236.2017.05.029

• 预防兽医 • 上一篇    下一篇

IL-10在结核分枝杆菌感染和免疫中作用的研究进展

竺婷婷1,2, 卜棚1,2, 刘晗1,2, 彭永崇1,2, 陈颖钰1,2, 郭爱珍1,2   

  1. 1. 华中农业大学农业微生物学国家重点实验室, 武汉 430070;
    2. 华中农业大学动物医学院, 武汉 430070
  • 收稿日期:2016-10-31 出版日期:2017-05-20 发布日期:2017-05-18
  • 通讯作者: 陈颖钰, 郭爱珍 E-mail:chenyingyu@mail.hzau.edu.cn;aizhen@mail.hzau.edu.cn
  • 作者简介:竺婷婷(1990-),女,浙江奉化人,硕士,研究方向:动物传染病及病原分子流行病学研究,E-mail:553238808@qq.com
  • 基金资助:

    国家自然科学基金面上项目(31472219);现代农业(肉牛牦牛)产业技术体系专项基金(CARS-38)

Research Progress on Role of IL-10 in Immunodulation during Mycobacterium tuberculosis Infection

ZHU Ting-ting1,2, PU Peng1,2, LIU Han1,2, PENG Yong-chong1,2, CHEN Ying-yu1,2, GUO Ai-zhen1,2   

  1. 1. State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China;
    2. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
  • Received:2016-10-31 Online:2017-05-20 Published:2017-05-18

摘要:

白细胞介素10(interleukin 10,IL-10)是一种多功能、多细胞源性的细胞因子,因其具有强抗炎和免疫抑制活性而成为研究热点。在结核病的发生发展中,IL-10的免疫抑制作用受到了研究者的关注,其既能抑制天然免疫,也能影响获得性免疫。研究者普遍认为IL-10与结核分枝杆菌的免疫逃避及潜伏性感染有关。鉴于其在结核分枝杆菌感染中独特的作用,作者对近几年IL-10在结核分枝杆菌免疫逃避、潜伏感染、临床辅助治疗及自身表达调控等方面的研究进展进行了综述。

关键词: IL-10; 结核分枝杆菌; 免疫调控; 感染

Abstract:

Interleukin 10 (IL-10) is a versatile and multi-cell derived cytokine, which has attracted the great attention of researchers because of its strong anti-inflammation and immunosuppression activities. It can not only inhibit the innate but also adaptive immunity. Generally, it is believed that IL-10 is closely related to immune evasion and latent infection by Mycobacterium tuberculosis (MTB). In view of its unique role in MTB infection, progress of role of IL-10 on immune evasion, latent infection, clinical chemotherapies and self-regulation of its expression during MTB infection were reviewed.

Key words: IL-10; Mycobacterium tuberculosis; immunomodulation; infection

中图分类号: