两种复合型卵黄免疫球蛋白粉对仔猪腹泻病防治效果的研究

doi:10.16431/j.cnki.1671-7236.2016.05.036

›› 2016, Vol. 43 ›› Issue (5): 1361-1367.doi: 10.16431/j.cnki.1671-7236.2016.05.036

两种复合型卵黄免疫球蛋白粉对仔猪腹泻病防治效果的研究

彭姣¹, 徐丁², 白挨泉³, 卢超², 祁振强^1,2

1. 深圳市宝舜泰生物医药股份有限公司, 深圳 518000;
2. 深圳市维德营养饲料有限公司, 深圳 518000;
3. 佛山科学技术学院, 佛山 528200

收稿日期:2015-11-19 出版日期:2016-05-20 发布日期:2016-05-23
通讯作者: 祁振强 E-mail:qizhenqiang1111@vip.163.com
作者简介:彭姣(1986-),女,江西吉安人,硕士,研究方向:生物化学与分子生物学,E-mail:379511345@qq.com
基金资助:
国家星火计划项目(2014GA781002)

Study on Effect of Two Types of Compound Immunoglobulin Yolk Powder on Post-weaning Swine Diarrhea

PENG Jiao¹, XU Ding², BAI Ai-quan³, LU Chao², QI Zhen-qiang^1,2

1. Shenzhen Boostie Biological Pharmaceutical Co., Ltd., Shenzhen 518000, China;
2. Shenzhen Vidoo Nutrition Feed Co., Ltd., Shenzhen 518000, China;
3. Foshan University, Foshan 528200, China

Received:2015-11-19 Online:2016-05-20 Published:2016-05-23

摘要/Abstract

摘要： 试验旨在开发能够有效预防和治疗仔猪细菌性腹泻和病毒性腹泻的卵黄免疫球蛋白粉相关产品,将卵黄抗体的先进技术更好地应用于畜牧养殖中。采用两种复合型卵黄免疫球蛋白粉对人工感染细菌(ETEC)和病毒(PEDV和TGEV)的21日龄断奶仔猪进行预防和治疗试验。将复合型卵黄免疫球蛋白粉Ⅰ型按0.4%添加至仔猪断奶日粮中,攻毒后仔猪没有出现死亡情况,只有5头仔猪在攻毒初期出现轻微腹泻情况,随着饲喂的继续,5头仔猪腹泻很快得到控制,而攻毒对照组仔猪全部死亡;对21日龄仔猪攻毒,攻毒24h内仔猪陆续出现腹泻症状。在攻毒24h后采用复合型卵黄免疫球蛋白粉Ⅱ型产品以1∶3的比例配以葡萄糖生理盐水进行灌服治疗,经3d治疗后仔猪腹泻情况得到很大的改善,5d后腹泻仔猪基本痊愈,治愈率可达84%~88%。对存活仔猪进行带毒检测,结果显示,预防组存活仔猪带毒水平较其他组更低,治疗组其次,而药物治疗对照组带毒情况严重。

关键词: 复合型卵黄免疫球蛋白粉; 仔猪腹泻; 攻毒试验

Abstract: For developing immunoglobulin yolk powder products to prevent and treat the diarrheal piglets, and appling the advanced technology of egg yolk antibody to the husbandry and aquaculture, two types of compound immunoglobulin yolk powder were used to prevent and treat the diarrhea piglets which were challenged with ETEC, PEDV and TGEV.The creep feed added with 0.4% typeⅠimmunoglobulin yolk powder was provided to experimental piglets.There was no death after challenging the piglets with ETEC or virus, only 5 minor diarrhea in piglets in the early infection.As feeding continuing, the 5 piglets diarrhea quickly brought under control, conversely, the piglets in negative control group were totally dead.The immunoglobulin yolk powder type Ⅱ mixed with GNS at the rate of 1∶3 was used to cure the diarrhea piglets, 20 mL per piglet and 2 times a day.After curing for 3 days, the diarrhea was greatly improved, for 5 days the piglets diarrhea was basic recovery, and the survival rate could reach 84% to 88%.Dectected the infected of surviving piglets, compared to the drug treatment control group, prevention group had the lowest pathogen amounts, and the drug treatment control group had the most serious infected.

Key words: compound immunoglobulin yolk powder; post-weaning swine diarrhea; challenge test

中图分类号:

S859

彭姣, 徐丁, 白挨泉, 卢超, 祁振强. 两种复合型卵黄免疫球蛋白粉对仔猪腹泻病防治效果的研究[J]. , 2016, 43(5): 1361-1367.

PENG Jiao, XU Ding, BAI Ai-quan, LU Chao, QI Zhen-qiang. Study on Effect of Two Types of Compound Immunoglobulin Yolk Powder on Post-weaning Swine Diarrhea[J]. , 2016, 43(5): 1361-1367.

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两种复合型卵黄免疫球蛋白粉对仔猪腹泻病防治效果的研究

Study on Effect of Two Types of Compound Immunoglobulin Yolk Powder on Post-weaning Swine Diarrhea

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