禽大肠杆菌病疫苗研究进展

doi:10.16431/j.cnki.1671-7236.2015.01.037

摘要/Abstract

摘要： 禽致病性大肠杆菌(APEC)是引起家禽多种肠外疾病如气囊炎、心包炎、肝周炎、蜂窝织炎及败血症的主要人畜共患病原菌.在过去的数十年间,试验了多种不同类型的疫苗用于本病的控制.鉴于APEC血清型较多且不同血清型之间缺乏交叉免疫保护,故生产上使用的APEC疫苗研究进展缓慢.作者对不同类型APEC疫苗进行了综述并提出未来的研究方向.

关键词: 禽大肠杆菌病; 灭活疫苗; 弱毒疫苗; 亚单位疫苗; 广谱疫苗; 未来疫苗

Abstract: Avian pathogenic Escherichia coli (APEC) is one of the most important zoonotic pathogens of a number of extra-intestinal diseases in the poultry industry, including airsacculitis, pericarditis, perihepatitis, cellulitis and septicemia. Various types of vaccine have been tested over the past few decades for control of avian colibacillosis. Unfortunately, vaccines used in poultry production make the slow progress of the researches, to date, as APECs are serotypically diverse with vaccines failing to cross-protection against heterologous challenge. Herein, we review the different categories of APEC vaccines that have been tested and provide an insight into the future of APEC vaccines.

Key words: avian colibacillosis; inactivated vaccine; attenuated vaccine; subunit vaccine; broad-spectrum vaccine; future vaccine

中图分类号:

S858.3

马兴树. 禽大肠杆菌病疫苗研究进展[J]. , 2015, 42(1): 234-244.

MA Xing-shu. Research Progress on Vaccines of Avian Colibacillosis[J]. , 2015, 42(1): 234-244.

参考文献

[1] Johnson T J,Wannemuehler Y,Johnson S J,et al. Comparison of extraintestinal pathogenic Escherichia coli from human and avian sources reveals a mixed subset representing potential zoonotic pathogens[J]. Appl Environ Microbiol,2008,74:7043-7050.
[2] Tivendale K A,Logue C M,Kariyawasam S,et al. Avian pathogenic Escherichia coli strains are similar to neonatal meningitis E.coli strains and are able to cause meningitis in the rat model of human disease[J]. Infection and Immunity,2010,78(8):3412-3419.
[3] Gyles C L. Antimicrobial resistance in selected bacteria from poultry[J]. Anim Health Res Rev,2008,9:149-158.
[4] 马兴树,范翠蝶,夏玉龙. 禽致病性大肠杆菌研究进展[J]. 中国畜牧兽医,2013,40(2):169-173.
[5] Gross W B. Pathological changes of an Escherichia coli infection in chickens and turkeys[J]. American Journal of Veterinary Research,1957,18:724-730.
[6] Deb J R,Harry E G. Laboratory trials with inactivated vaccines against Escherichia coli(O78 K80) infection in fowls[J]. Res Vet Sci,1976,20:131-138.
[7] Deb J R,Harry E G. Laboratory trials with inactivated vaccines against Escherichia coli (O2:K1) infection in fowls[J]. Res Vet Sci,1978,24:308-313.
[8] Panigraphy B,Gyimah J E,Hall C F,et al. Immunogenic potency of an oil-emulsified Escherichia coli bacterin[J]. Avi Dis,1984,28:475-481.
[9] Gyimah J E,Panigrahy B. Immunogenicity of an Escherichia coli (serotype O1) pili vaccine in chickens[J]. Avi Dis,1985,29:1078-1083.
[10] Schwartz T M,Jayappa H G. Laboratory testing of a new killed E.coli vaccine for chickens and turkeys[A].34th Western Poultry Disease Conference[C].Davis,CA,March,1985.
[11] Arp L H. Consequences of active or passive immunization of turkeys against Escherichia coli O78[J]. Avi Dis,1980,24:808-815.
[12] Melamed D,Leitner G,Heller E D. A vaccine against avian colibacillosis based on ultrasonic inactivation of Escherichia coli[J]. Avi Dis,1991,35:17-22.
[13] Chaffer M,Schwartsburd B,Heller E D. Vaccination of turkey poults against pathogenic Escherichia coli[J]. Avian Pathol,1997,26:377-390.
[14] Abdul-Aziz T A,EI-Sukhon S N. Serum sensitivity and apathogenicity for chickens and chick embryos of Escherichia coli J5 strain[J]. Vet Res,1996,27:267-271.
[15] Abdul-Aziz T A,el-Sukhon S N. Chickens hyperimmunized with Escherichia coli J5 strain are protected against experimental challenge with Escherichia coli O78 serotype[J]. Veterinary Research Communications,1998,22:7-9.
[16] Woolcock J B. Pathogenesis of bacterial infections:Determinants of virulence in Gram negative bacteria[J].Australian Veterinary Journal,1985,62:177-181.
[17] Rosenberger J K,Fries P A,Cloud S S. In vitro and in vivo characterization of avian Escherichia coli.Ⅲ.immunization[J]. Avi Dis,1985,29:1108-1117.
[18] Heller E D,Leitner H,Drabkin N,et al. Passive immunisation of chicks against Escherichia coli[J]. Avian Pathol,1990,19:345-354.
[19] Dho-Moulin M,Fairbrother J M. Avian pathogenic Escherichia coli(APEC)[J]. Vet Res,1999,30:299-316.
[20] Jalava K,Hensel A,Szostak M,et al. Bacterial ghosts as vaccine candidates for veterinary applications[J]. J Controlled Release,2002,85:17-25.
[21] Mayr U B,Haller C,Haidinger W,et al. Bacterial ghosts as an oral vaccine:A single dose of Escherichia coli O157:H7 bacterial ghosts protects mice against lethal challenge[J]. Infection and Immunity,2005,73(8):4810-4817.
[22] Ghunaim H,Abu-Madi M A,Kariyawasam S. Advances in vaccination against avian pathogenic Escherichia coli respiratory disease:Potentials and limitations[J]. Veterinary Microbiology,2014,172:13-22.
[23] Frommer A,Freidlin P,Heller E D,et al. Adherence-associated characteristics and pathogenicity of Escherichia coli from avian colibacillosis[J].Avian Pathol,1990,19:547-554.
[24] Frommer A,Freidlin P J,Bock R R,et al. Experimental vaccination of young chickens with a live,non-pathogenic strain of Escherichia coli[J].Avian Pathol,1994,23:425-433.
[25] Nivas S C,Pomeroy B S. Attenuation of pathogenic Escherichia coli using acridine orange[A]. In:Abstracts of Conference of Research Workers on Animal Diseases[C].Chicago,1985.
[26] Naveh M W,Ron E Z. Vaccination against colisepticemia in chickens[A].35th Western Poultry Disease Conference[C].1985.
[27] 罗贤忠,黄青云,林泰松. 禽大肠杆菌血清型O2、O78融合双价弱毒菌株免疫原性的研究[J]. 华南农业大学学报,1998,19(2):50-54.
[28] 黄青云,罗金顶,任涛,等. 禽大肠杆菌耐药标记弱毒菌株O2(Nor^r,Chl^s)和O78(Chl^r,Nor^s)的培育[J]. 华南农业大学学报,1997,18(2):89-93.
[29] 陈红英,黄青云,陈根植. 禽大肠杆菌O2、O78及其耐药融合菌株的外膜蛋白免疫研究[J]. 华南农业大学学报,2005,26(1):106-109.
[30] Kwaga J K,Allan B J,van der Hurk J V,et al. A carAB mutant of avian pathogenic Escherichia coli serogroup O2 is attenuated and effective as a live oral vaccine against colibacillosis in turkeys [J]. Infection and Immunity,1994,62:3766-3772.
[31] Peighambari S M,Hunter D B,Shewen P E,et al. Safety,immunogenicity,and efficacy of two Escherichia coli cya crp mutants as vaccines for broilers[J]. Avi Dis,2002,46:287-297.
[32] Kariyawasam S,Wilkie B N,Gyles C L. Construction,characterization,and evaluation of the vaccine potential of three genetically defined mutants of avian pathogenic Escherichia coli[J]. Avi Dis,2004,48:287-299.
[33] Salehi T Z,Tabatabaei S,Karimi V,et al. Assessment of immunity against avian colibacillosis induced by an aroA mutant containing increased serum survival gene in broilers[J]. Braz J Microbiol,2012,43:363-370.
[34] Filho T F,Fávaro C,Ingberman M,et al. Effect of spray Escherichia coli vaccine on the immunity of poultry[J]. Avi Dis,2013,57:671-676.
[35] Nagano T,Kitahara R,Nagai S. An attenuated mutant of avian pathogenic Escherichia coli serovar O78:A possible live vaccine strain for prevention of avian colibacillosis[J]. Microbiol Immunol,2012,56:605-612.
[36] Langermann S,Palaszynski S,Barnhart M,et al. Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination[J]. Science,1997,276:607-611.
[37] Gyimah J E,Panigrahy B. Immunogenicity of an Escherichia coli (serotype O1) pili vaccine in chickens[J]. Avi Dis,1985,29:1078-1083.
[38] Gyimah J E,Panigrahy B,Williams J D. Immunogenicity of an Escherichia coli multivalent pilus vaccine in chickens[J]. Avi Dis,1986,30:687-689.
[39] van den Bosch J F. Vaccine against E.coli septicaemia in poultry[P]. USPTO,USA,1993.
[40] Kariyawasam S,Wilkie B N,Gyles C L. Resistance of broiler chickens to Escherichia coli respiratory tract infection induced by passively transferred egg-yolk antibodies[J]. Vet Microbiol,2004,98:273-284.
[41] Vandemaele F,Bleyen N,Abuaboud O,et al. Immunization with the biologically active lectin domain of PapGⅡ induces strong adhesion-inhibiting antibody responses but not protection against avian pathogenic Escherichia coli[J].Avian Pathol,2006,35:238-249.
[42] Chart H,Griffiths E. Antigenic and molecular homology of the ferric enterobactin receptor protein of Escherichia coli[J]. J Gen Microbiol,1985,131:1503-1509.
[43] Bolin C A,Jensen A E. Passive immunization with antibodies against iron-regulated outer membrane proteins protects turkeys from Escherichia coli septicemia[J]. Infection and Immunity,1987,55:1239-1242.
[44] Le Roy D,Crouzier C,Dho-Moulin M,et al. Results of passive and active immunization directed against ferric aerobactin in experimental enterobacterial infections in mice and chickens[J]. Res Microbiol,1995,146:167-174.
[45] Emery D A,Straub D E,Huisinga R,et al. Active immunization using a siderophore receptor protein[P]. Publication,U.S.P.,USA.2000.
[46] Kariyawasam S,Wilkie B N,Hunter D B,et al. Systemic and mucosal antibody responses to selected cell surface antigens of avian pathogenic Escherichia coli in experimentally infected chickens[J]. Avi Dis,2002,46:668-678.
[47] Horne S M,Pfaff-McDonough S J,Giddings C W,et al. Cloning and sequencing of the iss gene from a virulent avian Escherichia coli[J]. Avi Dis,2000,44:179-184.
[48] Pfaff-McDonough S J,Horne S M,Giddings C W,et al. Complement resistance-related traits among Escherichia coli isolates from apparently healthy birds and birds with colibacillosis[J]. Avi Dis,2000,44:23-33.
[49] Rodriguez-Siek K E,Giddings C W,Doetkott C,et al. Characterizing the APEC pathotype[J].Vet Res,2005,36:241-256.
[50] Lynne A M,Foley S L,Nolan L K. Immune response to recombinant Escherichia coli Iss protein in poultry[J]. Avi Dis,2006,50:273-276.
[51] Lynne A M,Kariyawasam S,Wannemuehler Y,et al. Recombinant Iss as a potential vaccine for avian colibacillosis[J]. Avi Dis,2012,56:192-199.
[52] Provence D L,Curtiss R 3rd. Isolation and characterization of a gene involved in hemagglutination by an avian pathogenic Escherichia coli[J]. Infection and Immunity,1994,62:1369-1380.
[53] Kostakioti M,Stathopoulos C. Functional analysis of the Tsh autotransporter from an avian pathogenic Escherichia coli strain[J]. Infection and Immunity,2004,72:5548-5554.
[54] Delicato E R,de Brito B G,Konopatzki A P,et al. Occurrence of the temperature-sensitive hemagglutinin among avian Escherichia coli[J]. Avi Dis,2002,46:713-716.
[55] Otto B R,Sijbrandi R,Luirink J,et al. Crystal structure of hemoglobin protease,a heme binding autotransporter protein from pathogenic Escherichia coli[J].J Biological Chemistry,2005,280:17339-17345.
[56] Kobayashi R K T,Gaziri L C J,Vidotto M C. Functional activities of the Tsh protein from avian pathogenic Escherichia coli (APEC) strains[J]. J Vet Sci,2010,11(4):315-319.
[57] Durant L,Metais A,Soulama-Mouze C,et al. Identification of candidates for a subunit vaccine against extraintestinal pathogenic Escherichia coli[J]. Infection and Immunity,2007,75:1916-1925.
[58] Moriel D G,Bertoldi I,Spagnuolo A,et al. Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli[J]. PNAS,2010,107:9072-9077.
[59] Roland K,Curtiss R 3rd,Sizemore D. Construction and evaluation of a delta cya delta crp Salmonella typhimurium strain expressing avian pathogenic Escherichia coli O78 LPS as a vaccine to prevent airsacculitis in chickens[J]. Avi Dis,1999,43:429-441.
[60] Miller T,Fanton M,Nickelson S,et al. Safety and immunogenicity of bacterial and tobacco plant cell line derived recombinant native and mutant Escherichia coli heat-labile toxin in chickens[J]. Avian Pathol,2012,45:441-449.
[61] Bao Y,Zhai Z,Wang S,et al. Chaperonin GroEL:A novel phylogenetically conserved protein with strong immunoreactivity of avian pathogenic Escherichia coli isolates from duck identified by immunoproteomics[J].Vaccine,2013,31:2947-2953.
[62] Chaudhari A A,Lee J H. Evaluation of the adjuvant effect of Salmonella-based Escherichia coli heat-labile toxin B subunits on the efficacy of a live Salmonella-delivered avian pathogenic Escherichia coli vaccine[J]. Avian Pathol,2013,42:365-372.
[63] Ron R Z. Host specificity of septicemic Escherichia coli:Human and avian pathogens[J]. Current Opinions in Microbiology,2006,9:28-32.
[64] Dziva F,Stevens M P. Colibacillosis in poultry:Unravelling the molecular basis of virulence of avian pathogenic Escherichia coli in their natural hosts[J]. Avian Pathology,2008,37(4):355-366.