MDA5在先天性免疫抗病毒作用中的研究进展

doi:10.16431/j.cnki.1671-7236.2015.01.036

›› 2015, Vol. 42 ›› Issue (1): 230-233.doi: 10.16431/j.cnki.1671-7236.2015.01.036

MDA5在先天性免疫抗病毒作用中的研究进展

刘欢欢, 谢丽君, 邵志勇, 高洪, 严玉霖

云南农业大学动物科学技术学院, 昆明 650201

收稿日期:2014-07-14 出版日期:2015-01-20 发布日期:2015-02-06
通讯作者: 严玉霖 E-mail:yanyulin333@163.com
作者简介:刘欢欢(1989-), 男, 广东人, 硕士生, 研究方向:畜禽传染病病理
基金资助:
国家自然科学基金(31160496、31360599);云南省高校动物性食品安全与人兽共患病科技创新团队项目

Research Progress on Antiviral Effect of MDA5 in Innate Immunity

LIU Huan-huan, XIE Li-jun, SHAO Zhi-yong, GAO Hong, YAN Yu-lin

College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China

Received:2014-07-14 Online:2015-01-20 Published:2015-02-06

摘要/Abstract

摘要： 黑色素瘤分化相关基因5(melanoma differentiation-associated gene-5,MDA5)是胞浆内核酸受体,与病原相关分子模式(pathogen-associated molecular patterns,PAMPs)相结合,特异性地识别较长的双链RNA,功能与视黄酸诱导表达基因Ⅰ(retinoic acid-inducude gene Ⅰ,RIG-Ⅰ)相似,通过自身级联激活和招募结构域(CARD)与接头蛋白CARD同源相互作用之后,与接头蛋白线粒体连接蛋白(MAVS)(也叫VISA、Cardif或IPS-1)结合,相互作用后会导致RIG-Ⅰ样受体(RLR)在内膜上重新定位,一边招募来TRAF2/TRAF6活化IKK激酶复合物,从而激活转录因子NF-κB;另一边招募来TRAF3和TBK1,从而促进IRF3的磷酸化激活,活化后的转录因子NF-κB及IRF会进入细胞核,共同协作促进Ⅰ型干扰素基因的表达.

Abstract: Melanoma differentiation-associated gene-5 (MDA5) was a nucleic acid receptor in the cytoplasm, in combination with pathogen-associated molecular patterns (PAMPs), which specifically recognized a long double-stranded RNA, function was similar with retinoic acid-inducude gene Ⅰ (RIG-Ⅰ), after CARD-CARD interaction, it was combinated with the adaptor protein MAVS (also called VISA, Cardif or IPS-1), the interaction might result in the reposition of RLRs in intima, one side it recruited TRAF2/TRAF6 to activate IKK kinase complexes, thereby activating the transcription factor NF-κB; on the other side it recruited TRAF3 and TBK1, thereby promoting phosphorylated activation of IRF3, after activations of the transcription factor NF-κB and IRF, they would enter the nucleus, and work together to promote the expression of type Ⅰ interferon gene.

Key words: MDA5; adaptor protein; phosphorylation; type Ⅰ interferon

中图分类号:

S852.4

刘欢欢, 谢丽君, 邵志勇, 高洪, 严玉霖. MDA5在先天性免疫抗病毒作用中的研究进展[J]. , 2015, 42(1): 230-233.

LIU Huan-huan, XIE Li-jun, SHAO Zhi-yong, GAO Hong, YAN Yu-lin. Research Progress on Antiviral Effect of MDA5 in Innate Immunity[J]. , 2015, 42(1): 230-233.

参考文献

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MDA5在先天性免疫抗病毒作用中的研究进展

Research Progress on Antiviral Effect of MDA5 in Innate Immunity

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