哺乳动物附睾特异GPx5功能及其调节机制的研究进展

doi:10.16431/j.cnki.1671-7236.2018.09.020

Abstract

Abstract:

The sperm maturation in the epididymis is the key to mammalian male gametes gaining fertility capacity.Glutathione peroxidase-5 (GPx5) has a strong antioxidant effect as an antioxidant enzyme specifically expressed in the epididymis,which can regulate the concentration of reactive oxygen species in the epididymis microenvironment and protect spermatozoa from lipid peroxidation to maintain DNA integrity of sperm.GPx5 may also have a certain effect on sperm motility and acrosome reaction.The chromosomal location and the number of exons of GPx5 gene have certain interspecific differences.The expression of GPx5 gene is specific in different species,parts and developmental stages.The gene expression is regulated by factors such as androgen,PEA3 factor and ETV4 family.The authors reviewed the research advance on the structure and location,expression characteristics,function and regulation mechanism of specific GPx5 gene of mammalian epididymis in order to provide theoretical basis for further study on sperm antioxidant mechanism and improving male animal fertility.

Key words: epididymis; GPx5 gene; expression characteristics; anti-oxidation; sperm

CLC Number:

S814.4

LUAN Zhaojin, ZHANG Jiaxin. Research Progress on Function and Regulation Mechanism of Specific GPx5 of Mammalian Epididymis[J]. , 2018, 45(9): 2500-2506.

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Research Progress on Function and Regulation Mechanism of Specific GPx5 of Mammalian Epididymis

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