脂质体递药系统设计思路及其兽药应用研究进展

doi:10.16431/j.cnki.1671-7236.2016.07.034

Abstract

Abstract:

As an excellent pharmaceutical carrier,liposomes exhibit characteristics of wide drug loading range,high efficiency and low toxicity.Besides increasing stability and solubility of loading drugs,liposomes can ascribe targeting and sustained release features to loading drugs.Meanwhile,it can improve bioavailability of loading drugs.Based on the above characteristics,liposomes is becoming hot spot of research and application.This article reviewed construction methods of liposomes based on structure,particle design and chosen of preparation method.Combined with application and demands of veterinary medicine,research progress on application of liposome in the field of veterinary medicine was submitted.It is expected that this article will provide reference for the development of new drug delivery systems used in the field of veterinary medicine.

Key words: liposomes; drug delivery system; particle design; veterinary medicine

CLC Number:

S853.7

LIN Jia-hao, DONG Jun, LI Ge-bin, LIN De-gui. Research Process on Design of Liposomes as Drug Delivery System and Its Application in the Field of Veterinary Medicine[J]. , 2016, 43(7): 1884-1889.

References

[1] Torchilin V P.Recent advances with liposomes as pharmaceutical carriers[J].Nat Rev Drug Discov,2005,4(2):145-160.
[2] Atyabi F,Farkhondehfai A,Esmaeili F,et al.Preparation of pegylatednano-liposomal formulation containing SN-38:In vitro characterization and in vivo biodistribution in mice[J].Acta Pharm,2009,59(2):133-144.
[3] Kelly C,Jefferies C,CryanS A.Targeted liposomal drug delivery to monocytes and macrophages[J].J Drug Deliv,2011:727241-727251.
[4] Wang T,Deng Y,Geng Y,et al.Preparation of submicronunilamellar liposomes by freeze-drying double emulsions[J].Biochim Biophys Acta,2006,1758(2):222-231.
[5] Yu H,Teng L,Meng Q,et al.Development of liposomal Ginsenoside Rg3:Formulation optimization and evaluation of its anticancer effects[J].International Journal of Pharmaceutics,2013,450(1-2):250-258.
[6] Cern A, Golbraikh A,Sedykh A,et al.Quantitative structure-property relationship modeling of remote liposome loading of drugs[J].J Control Release,2012,160(2):147-157.
[7] Spera R,Apollonio F,Liberti M,et al.Controllable release from high-transition temperature magnetoliposomes by low-level magnetic stimulation[J].Colloids Surf B Biointerfaces,2015,131:136-140.
[8] Wang C,Wang X,Zhong T,et al.The antitumor activity of tumor-homing peptide-modified thermosensitive liposomes containing doxorubicin on MCF-7/ADR:In vitro and in vivo[J].Int J Nanomedicine,2015,10:2229-2248.
[9] Pacheco-Torres J,Mukherjee N,Walko M,et al.Image guided drug release from pH-sensitive ion channel-functionalized stealth liposomes into an in vivo glioblastoma model[J].Nanomedicine,2015,11:1345-1354.
[10] Allen T M,CullisP R.Liposomal drug delivery systems:From concept to clinical applications[J].Adv Drug Deliv Rev,2013,65(1):36-48.
[11] Mura P,Maestrelli F,Gonzalez-Rodriguez M L,et al.Development,characterization and in vivo evaluation of benzocaine-loaded liposomes[J].Eur J Pharm Biopharm,2007,67(1):86-95.
[12] C'uric' A,Reul R,Möschwitzer J,et al.Formulation optimization of itraconazole loaded PEGylated liposomes for parenteral administration by using design of experiments[J].International Journal of Pharmaceutics,2013,448(1):189-197.
[13] Yamamoto T,Yokoyama M,Opanasopit P,et al.What are determining factors for stable drug incorporation into polymeric micelle carriers? Consideration on physical and chemical characters of the micelle innercore[J].J Control Release,2007,123(1):11-18.
[14] Haran G,Cohen R,Bar L K,et al.Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases[J].Biochim Biophys Acta,1993,1151(2):201-215.
[15] Ruozi B,Riva G,Belletti D,et al.Cidofovir-loaded liposomes:An intro-study using BCBL-1 cell line as a model forprimary effusion lymphoma[J].Eur J Pharm Sci,2010,41(2):254-264.
[16] Villasmil-Sanchez S,Rabasco A M,Gonzalez-Rodriguez M L.Thermal and 31P-NMR studies to elucidate sumatriptan succinate entrapment behavior in phosphatidylcholine/cholesterol liposomes.Comparative 31P-NMR analysis on negatively and positively-charged liposomes[J]. Colloids Surf B Biointerfaces,2013,105:14-23.
[17] 侯新朴,崔东,辉徐成.药物结构修饰与脂质体载药[J].齐齐哈尔轻工学院学报,1989,5(4):10-14.
[18] 段逸松,于波涛,张志荣.米托蒽醌长循环脂质体的制备及药代动力学的研究[J].药学学报,2002,37:465-468.
[19] Awasthi V D,Garcia D,Goins R A,et al.Circulation and biodistribution profiles of long-circulating PEG-liposomes of various sizes in rabbits[J].Int J Pharm,2003,253(1-2):121-132.
[20] Sun W T,Zou W W,Huang G H,et al.Pharmacokinetics and targeting property of TFu-loaded liposomes with different sizes after intravenous and oral administration[J].J Drug Target,2008,16(5):357-365.
[21] 王健松,朱家壁,吕瑞勤,等.肺靶向阿奇霉素脂质体的制备及其在小鼠体内的分布[J].药学学报,2005,40(3):274-278.
[22] 许洁,杨志强.环孢素A脂质体制备及其体外释药方法学考察[J].抗感染药学,2008,5(4):222-227.
[23] Huang Y Y,Wang C H.Pulmonary delivery of insulin by liposomal carriers[J].J Controlled Release,2006,113:9-14.
[24] 李维凤,牛晓峰,张会侠,等.硝苯地平脂质体的研制[J].西安交通大学学报(医学版),2002,23(4):414-416.
[25] Giulio A D,Maurizi G,Odoardi P,et al.Encapsulation of ampicillin in reverse-phase evaporation liposomes:A direct evaluation by derivative spectrophotometry[J].International Journal of Pharmaceutics,1991,74(2-3):183-188.
[26] Otake K,Shimomura T,Goto T,et al.Preparation of liposomes using an improved supercritical reverse phase evaporation method[J].Langmuir,2006,22(6):2543-2550.
[27] Mayer L D,Hope M J,Cullis P R,et al.Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles[J].Biochim Biophys Acta,1985,817(1):193-196.
[28] Vemuri S,Rhodes C T.Preparation and characterization of liposomes as therapeutic delivery systems:A review[J].Pharm Acta Helv,1995,70(2):95-111.
[29] Zhang L,Han L,Sun X,et al.The use of PEGylated liposomes to prolong the circulation lifetime of salvianolic acid B[J].Fitoterapia,2012,83(4):678-689.
[30] Castile J D,Taylor K M.Factors affecting the size distribution of liposomes produced by freeze-thaw extrusion[J].Int J Pharm,1999,188(1):87-95.
[31] Sriwongsitanont S,Ueno M.Effect of freeze-thawing and polyethylene glycol (PEG) lipid on fusion and fission of phospholipid vesicles[J].Chem Pharm Bull (Tokyo),2004,52(5):641-642.
[32] Dos S N,Cox K A,McKenzie C A,et al.pH gradient loading of anthracyclines into cholesterol-free liposomes:Enhancing drug loading rates through use of ethanol[J].Biochim Biophys Acta,2004,1661(1):47-60.
[33] Barenholz Y.Doxil(R)-the first FDA-approved nano-drug:Lessons learned[J].J Control Release,2012,160(2):117-134.
[34] 叶鹏,宋金春,郭咸希,等.pH梯度法结合逆向蒸发法制备氟尿嘧啶脂质体[J].中国药师,2009,12(3):308-311.
[35] Rathbone M J,Gurny R.Controlled release veterinary drugdelivery:Biological and pharmaceutical considerations[M].Elsevier Amsterdam,2000.
[36] Kalat S A,Khamesipour A,Bavarsad N,et al.Use of topical liposomes containing meglumine antimoniate (Glucantime) for the treatment of L.major lesion in BALB/c mice[J].Experimental Parasitology,2014,43:5-10.
[37] 蒋松.阿苯达唑及其脂质体治疗绵羊肝包虫病效果比较[D].石河子:石河子大学,2009.
[38] 李红娇,王玮,张卫强,等.阿莫西林脂质体的制备及质量评价[J].中国兽药杂志,2013,47(2):35-37.
[39] 雷连成,陈伟,韩文瑜,等.氧氟沙星脂质体的制备及其抑菌实验的观察[J].中国兽药杂志,2002,36(5):32-33.
[40] 陈小军,孙志良,刘进辉,等.阿米卡星脂质体注射液的临床疗效研究[J].中国畜牧兽医,2009,36(1):98-99.
[41] 赵海焦,徐卫康,贾志华,等.连翘酯苷脂质体在雏鸡体内的药动学研究[J].中国畜牧兽医,2014,41(2):153-158.
[42] Nagata T,Toyota T,Ishigaki H,et al.Peptides coupled to the surface of a kind of liposome protect infection of influenza viruses[J].Vaccine,2007,25(26):4914-4921.
[43] 王志龙,张文生,高晨,等.鸡转移因子脂质体对新城疫免疫效果影响的研究[J].黑龙江畜牧兽医,2012,5:128-129.
[44] Hawkyard M,Laurel B,Barr Y,et al.Evaluation of liposomes for the enrichment of rotifers (Brachionus sp.) with taurine and their subsequent effects on the growth and development of northern rock sole (Lepidopsetta polyxystra) larvae[J].Aquaculture,2015,441:118-125.
[45] 张文奎,李培锋,刘晓松,等.抗犬细小病毒核糖核酸SA-阳离子脂质体的研究[J].内蒙古畜牧科学,2003,6:15-19.
[46] 丁维,贾杏林,芮小庆,等.猫异源输入猪血红蛋白脂质体的初步试验[J].动物医学进展,2013,5:125-128.
[47] 杜保生,颜天华,王秋娟.注射用尼莫地平脂质体对麻醉犬脑循环的影响[J].中国新药与临床杂志,2007,7:493-496.

Research Process on Design of Liposomes as Drug Delivery System and Its Application in the Field of Veterinary Medicine

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