Abstract: Mesoporous material is a new type of porous solid material with pore size between 2-50 nm.Because of its large specific surface area,excellent chemical and thermal stability,adjustable pore size and low density,mesoporous material has become a promising drug delivery system (DDSs).However,there are still some challenges in clinical application of mesoporous material-based DDSs.In order to systematically summarize the research progress of mesoporous materials in drug delivery and to develop drug carriers based on mesoporous materials more efficiently,the authors classified mesoporous materials according to their spatial distribution order and chemical composition,which were divided into ordered mesoporous materials and disordered mesoporous materials according to their spatial distribution,and silicon-based mesoporous materials and non-silicon-based mesoporous materials according to their chemical composition.Then,the common synthesis methods were introduced,including sol-gel method,hydrothermal synthesis method,microwave synthesis method,phase transformation method and precipitation method,among which sol-gel method and hydrothermal synthesis method were the most commonly used.At the same time,the research progress of typical and most widely studied mesoporous materials in chemical and biotechnology drug delivery and the effects of the type,pore size,surface functional groups and physical state of mesoporous materials on drug delivery efficiency were also introduced.Finally,the existing problems and future development direction of DDSs based on mesoporous materials were discussed in this paper.

Key words: mesoporous material; synthesis; drug delivery system(DDSs)