肉鸡日粮中1α-羟基维生素D3与25-羟基维生素D3生物学效价比较研究

doi:10.16431/j.cnki.1671-7236.2015.12.020

Abstract

Abstract: The study was conducted to determine the relative bioavailability (RBV) of 1α-hydroxycholecalciferol (1α-OH-D₃) to 25-hydroxycholecalciferol (25-OH-D₃) in Ross 308 broiler chickens from 1 to 42 days of age.300 one-day-old Ross 308 broilers were randomly assigned into 6 groups with 5 replicates per group and 10 chicks per replicate.The six groups were fed with basal diets in which 2.5,5.0,10.0 μg/kg 25-OH-D₃ and 1.25,2.5,5.0 μg/kg 1α-OH-D₃ were added,respectively.The RBV of 1α-OH-D₃ to 25-OH-D₃ was determined by the slope ratio method.The results showed that average body weight gain (ABWG),feed to gain ratio (F/G),plasma phosphorus (P) were improved with the 1α-OH-D₃ and 25-OH-D₃ addition and the tibia and femur weight,length,and ash weight were linearly increased with the levels of 1α-OH-D₃ or 25-OH-D₃ increasing (P< 0.05).Using ABWG,F/G,and plasma P as the criteria,RBV of 1α-OH-D₃ to 25-OH-D₃ were 2.16,2.56,and 2.77.Using tibia weight,length,width,and ash weight as the criteria,RBV of 1α-OH-D₃ to 25-OH-D₃ were 1.80,1.88,2.42,and 2.04.Using femur weight,length,and ash weight as the criteria,RBV of 1α-OH-D₃ to 25-OH-D₃ were 1.89,1.98,and 2.18.These results indicated that the activity of 1α-OH-D₃ was approximately 2.17 times higher than that of 25-OH-D₃in promoting growth performance and bone mineralization in broiler chickens from 1 to 42 days of age.

Key words: 1α-OH-D₃; 25-OH-D₃; bioavailability; growth performance; bone mineralization; broiler chick

CLC Number:

S831.5

HAN Jin-cheng, WANG Jian-guo, CHEN Guan-hua, ZHANG Jin-long, QU Hong-xia, ZHANG Jin-liang, XI Li, YAN Yong-feng. Study on Relative Bioavailability of 1α-Hydroxycholecalciferol to 25-Hydroxycholecalciferol in Broiler Chickens[J]. , 2015, 42(12): 3246-3252.

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Study on Relative Bioavailability of 1α-Hydroxycholecalciferol to 25-Hydroxycholecalciferol in Broiler Chickens

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