C5a受体颉颃剂及其在动物疾病模型治疗中的研究进展

Abstract

Abstract: As a key part of the complement system in human and animal body, C5a receptor combined with C5a has been considered to mediate numerous biological processes and be involved in the pathology of numerous inflammatory diseases, such as ischemia-reperfusion injury, acute lung injury, sepsis, rheumatoid arthritis and glomerular nephritis．Therefore, current studies focus on how to block C5a receptor and dampen the inflammatory reaction. This review provides a brief overview of the current development of C5a receptor antagonists and their treatment in animal disease model.

Key words: C5a; C5a receptor; antagonists; complement; treatment

ZHANG Ze-ying, LIU Dong-xu. Research Progress on C5a Receptor Antagonists and their Treatment in Animal Disease Model[J]. China Animal Husbandry & Veterinary Medicine.

References

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Research Progress on C5a Receptor Antagonists and their Treatment in Animal Disease Model

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