DNA甲基化、组蛋白修饰与基因沉默

Abstract

Abstract: DNA methylation, histone deacetylation, and methylation of histone H3 at lysine 9 are the three bestcharacterized covalent modifications associated with a repressed chromatin state, and they are all involved in genes silencing. Recent advances highlight an intricate connection of interactions among these processes, generating a selfreinforcing epigenetic cycle that might perpetuate a repressed chromatin state. Histone deacetylation and methylation at lysine 9 of H3 might also contribute to the establishment of DNA methylation patterns. What's more, the recent studies show that CpG methylation and other histone modifications are correlated. 

Key words: DNA; histones; methyltransferase; methylation; genes silencing

CLC Number:

Q754

SUO Xiaojun;ZHANG Nian. DNA Methylation, Histone Modifications and Genes Silencing [J]. China Animal Husbandry & Veterinary Medicine, 2007, 34(2): 82-85.

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DNA Methylation, Histone Modifications and Genes Silencing

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