动物生长轴中STAT调控胰岛素样生长因子Ⅰ 表达的研究进展

Abstract

Abstract: Insulin-like growth factor-Ⅰ (IGF-Ⅰ) is an important endocrine and paracrine regulator of cell proliferation and metabolism. GH signaling is initiated by binding of two distinct sites of the GH molecule to two GHR monomers, which is followed by receptor dimerization and activation of Janus kinase 2 (JAK-2) tyrosine kinase, then induces MAPKs, tyrosine phosphorylation of GHR and other intracellular proteins such as insulin receptor substrate-1 and signal transducers and activators of transcription (STAT1, STAT3, and STAT5). The activated STAT proteins accumulate in the nucleus to drive the transcription of IGFs, and IGFs translocate to local tissue by blood circulation and promote the development and differentiation of tissues and cells. GH mediated by IGF-Ⅰ regulates animal growth and cell differentiation. We will discuss the constitution and function of STAT and IGF-Ⅰ and relationship between both of them in animal’s growth axis in this review.

Key words: STAT; IGF-Ⅰgene; regulation

CLC Number:

WANG Hui-juan, YU Jian-feng, GU Zhi-liang. Research Progress of STAT Mediated IGF-Ⅰ Expression in Animal’s GH/IGF-Ⅰ Axis[J]. .

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Research Progress of STAT Mediated IGF-Ⅰ Expression in Animal’s GH/IGF-Ⅰ Axis

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