羊用布鲁氏菌病疫苗研究进展

doi:10.16431/j.cnki.1671-7236.2024.09.032

Abstract

Abstract: Brucellosis is an important zoonotic disease caused by Brucella, which is widely prevalent worldwide, causing serious economic losses and threatening public health safety. China is one of the countries with severe outbreaks of brucellosis.Implementing vaccination in high prevalence areas is one of the effective strategies to prevent the spread of brucellosis.Currently, the main prevalent strain in China is Brucella melitensis, and the infected sheep/goat are the main sources of infection for Brucella.At present, vaccines available in China for the prevention of sheep/goat brucellosis include conventional attenuated vaccines such as Brucella melitensis strain Rev.1, Brucella melitensis strain M5/M5-90 and Brucella suis strain S2, as well as newly approved Brucella melitensis strains M5-90Δ26 and BA0711.Although there are many types of vaccines that can be used to prevent sheep/goat brucellosis, existing vaccines have two obvious shortcomings.Firstly, their safety is insufficient, and immunization of pregnant animals can cause miscarriage, and the vaccine strain and the wild strain are both smooth, which interferes with clinical diagnosis after immunization.Therefore, it is still urgent to develop a highly safe and non-invasive brucellosis vaccine.This paper provides a review of the application of sheep/goat brucellosis vaccines and the research status of new vaccines.

Key words: zoonosis; brucellosis of sheep/goat; vaccine

CLC Number:

S855.1⁺2

QIU Dongxu, LYU Lang, PI Xiangcheng, FENG Yu, JIANG Hui, CHEN Xiang, DING Jiabo. Research Progress on Brucellosis Vaccine for Sheep and Goat[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(9): 4043-4051.

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Research Progress on Brucellosis Vaccine for Sheep and Goat

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