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Effects of Dietary Supplemented with Different Levels of L-arginine on Serum IL-2, IFN-γ and IL-4 in Pregnant Rex Rabbit

PENG Yi-zhu1, DU Guang-ying1, WANG Duo-jia1, LIU Chang1, SHAO Da-fu1, FEI Zhong-ping2, HE Juan3, ZHANG Jing1, MENG Yang3, TANG Hong-yu1, ZHANG Meng-han1, TANG Xin1, SHEN Jing-lin1   

  1. 1. College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062,China;
    2. The Logistics Department of Department of Agriculture, Jilin University,Changchun 130062,China;
    3. The Five Star Animal Health Pharmaceutical Companies, Jilin University,Changchun 130062,China
  • Received:2012-06-04 Online:2012-08-20 Published:2012-08-24

Abstract: This study was designed to explore the impact of different L-arginine levels on the pregnant Rex rabbit serum Th1 and Th2 cytokines and provided a theoretical basis for the development of pregnancy Rex rabbit feed. Seventy-two estrus Rex rabbits were randomly divided into six groups: the group 1 to the group 6. The levels of IL-2, IFN-γ and IL-4 were measured by ELISA at 10 days, 20 days and 30 days in pregnancy serum. The results showed that the levels of IL-2 with the groups 4,5,6 were significantly lower than the groups 1,2,3(P＜0.05) in 10 days of pregnancy; the levels of IL-2 with the groups 3,4,5,6 were significantly lower than the groups 1,2 (P＜0.05) in pregnancy 20 days and 30 days. While the levels of IL-4 with the groups 3,4,5,6 were significantly higher than the groups 1,2 (P＜0.05) in pregnancy 10 days and 30 days,the levels of IL-4 with the groups 2,3,4,5,6 were significantly higher than the group 1 (P＜0.05) in pregnancy 20 days. The concentration of IFN-γ significantly decreased when the addition of Arg was in the 0.15%, and no longer significantly changed with the increasing of Arg. Therefore, 0.3% was the optimal added amount for pregnancy Rex rabbit.

Key words: rabbit; gestation; diet; L-arginine; cytokine

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